A5025908349- Hepatitis B Virus Studies
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Nail Diseases and Treatments
- Fungal Infections and Studies
- Dermatological and Skeletal Disorders
- Neurological diseases and metabolism
- Full-Duplex Wireless Communications
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Cutaneous lymphoproliferative disorders research
- Psoriasis: Treatment and Pathogenesis
- Parvovirus B19 Infection Studies
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Neonatal skin health care
- Lysosomal Storage Disorders Research
- Corporate Law and Human Rights
- Vector-Borne Animal Diseases
- Electroconvulsive Therapy Studies
- Chemical Synthesis and Analysis
Istituti Ospitalieri di Cremona
2023
University of Milan
2018-2021
Fondazione IRCCS Istituto Neurologico Carlo Besta
2019-2021
Center for Strategic Research
2021
University of Tyumen
2021
Financial University
2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018
Politecnico di Milano
2017
University of Brescia
2017
University of Verona
2017
Abstract Background Protease inhibitors (PIs) to treat hepatitis C (HCV) virus infection have been approved and others are under development. Results The aims of this study were illustrate natural polymorphisms in the HCV protease measure frequency PI resistance mutations different genotypes from PI-naïve patients. Direct sequencing NS3/4A was performed 156 patients naïve PIs who infected with genotype 1a (n = 31), 1b 39), 2 30), 3 33) 4 23). Amino acid (aa) substitutions associated found...
Epstein-Barr virus (EBV) DNA levels in whole-blood samples of 54 pediatric patients receiving T-cell-depleted haploidentical hematopoietic stem cell transplantation (HSCT) 2003 to 2007 were retrospectively compared with EBV loads peripheral blood mononuclear cells (PBMC). Determination whole missed 1 19 (5.2%), who tested positive for PBMC. The analytical sensitivity detection relative that PBMC was 94.7%. Regression analysis showed a significant correlation between and (r = 0.81; P <...
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease due to motor neuron loss variably associated with frontotemporal dementia (FTD). Next generation sequencing technology revealed increasing number of rare and novel genetic variants interpretation their pathogenicity represents a major challange in the diagnosis ALS. We selected 213 consecutive patients sporadic or familial (16%) ALS, tested negative for SOD1, FUS, TARDBP, C9orf72 mutations. To reveal...
Lombardy was severely hit by the COVID-19 pandemic since February 2020 and Health System underwent rapid reorganization. Outpatient clinics were stopped for non-urgent patients: it became a priority to manage hundreds of fragile neurological patients who suddenly had less reference points. In Italy, before pandemic, Televisits neither recognized nor priced. At Fondazione IRCCS Istituto Neurologico C. Besta, we reorganized outpatient deliver Neuro-telemedicine services, including...
Abstract Transplantation Centers using human cytomegalovirus (HCMV) antigenemia‐based preemptive therapy will need to replace in the near future antigenemia assay with a more standardized and automatable assay, such as molecular quantifying HCMV DNA blood (DNAemia). Thus, view of replacing clinically safe cutoff values, DNAemia levels corresponding cutoffs guiding were determined retrospectively solid organ hematopoietic stem cell transplant recipients (HSCTR) an “in‐house” quantitative PCR...
Abstract Pathogenic variants in polynucleotide kinase 3′‐phosphatase ( PNKP ) gene have been associated with two distinct clinical presentations: autosomal recessive microcephaly, seizures, and developmental delay (MCSZ; MIM 613402) ataxia oculomotor apraxia type 4 (AOA4; 616267). More than 40 patients reported so far, their presentations revealed a continuum phenotypic spectrum ranging from congenital microcephaly early‐onset intractable to adult onset slowly progressive sensory‐motor...
ABSTRACT An immunoassay detecting hepatitis C virus core antigen was evaluated for its ability to predict clinical outcome in a series of patients with acute C. In subjects who cleared the virus, no longer detectable within 16 weeks onset, whereas considerable fluctuations were noted among progressing chronic hepatitis, one whom showed consistently negative values despite intermittent presence viral RNA.
Floating‐Harbor Syndrome (FHS; OMIM #136140) is an ultra‐rare autosomal dominant genetic condition characterized by expressive language delay, short stature with delayed bone mineralization, a triangular face prominent nose, and deep‐set eyes, hand anomalies. First reported in 1973, FHS associated mutations the SRCAP gene, which encodes SNF2‐related CREBBP activator protein. Mutations gene cause Rubinstein‐Taybi (RSTS; #180849, #613684), another rare disease broad thumbs halluces, facial...
The study aimed to evaluate the immune response a recombinant hepatitis B vaccine in young patients with insulin-dependent diabetes mellitus (IDDM), view of reports reduced efficacy adults IDDM. Sixty-five people IDDM, age 4.5 27.5 and duration 0.3 19 years 174 age- sex-matched healthy subjects were injected at 0, 1, 6 months intramuscularly deltoid region. Three (4.6 %) IDDM 2 (1.1 controls non-responders (HBsAb titre, <2 IU l−1) 1 control was low responder titre = 10 l−1). Among 3...
We describe an HIV-positive patient suffering from cutaneous cryptococcosis who was a former intravenous drug abuser and presented nodulo-ulcerated lesion on the back of his left hand. This caused 4 months previously when injured by pigeon nesting in abandoned house. After fluconazole treatment for months, no other visceral infections were recorded 18 after complete healing lesion.