A5056076273- Fibromyalgia and Chronic Fatigue Syndrome Research
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Gut microbiota and health
- Environmental Justice and Health Disparities
- Air Quality and Health Impacts
- Prenatal Substance Exposure Effects
- Climate Change and Health Impacts
- Health, psychology, and well-being
- Musculoskeletal pain and rehabilitation
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects and Toxicity Studies
- Pesticide Exposure and Toxicity
- Maternal Mental Health During Pregnancy and Postpartum
- Diet and metabolism studies
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Phytoestrogen effects and research
- Neonatal and fetal brain pathology
- Per- and polyfluoroalkyl substances research
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Spaceflight effects on biology
Boston University
2015-2024
Creative Commons
2016
Gallagher (United States)
2016
University of California, Irvine
2016
National Institute of Environmental Health Sciences
2016
University of Massachusetts Boston
2007-2015
Groupe Lépine (France)
2015
Boston Public Schools
2013
University of Cape Town
2005-2006
University of KwaZulu-Natal
2006
Mounting evidence over the past several decades has demonstrated inequitable distribution of pollutants ambient origin between sociodemographic groups in United States. Most environmental inequality studies to date are cross-sectional and used proximity-based methods rather than modeled air pollution concentrations, limiting ability examine trends time or factors that drive exposure inequalities. In this paper, we use 1 km2 PM2.5 NO2 concentrations Massachusetts an 8-year period Census...
Gulf War Illness (GWI) is a chronic multi-symptom disorder affecting the central nervous system (CNS), immune and gastrointestinal (GI) systems of veterans (GWV). We assessed relationships between GWI, GI symptoms, gut microbiome inflammatory markers in GWV from Boston Consortium (GWIC). Three groups GWIC were recruited this pilot study; without GWI no symptoms (controls), with (GWI-GI), who reported (GW+GI). Here we report on subset first thirteen stool samples analyzed. Results showed...
The Gulf War Illness Consortium (GWIC) was designed to identify objective biomarkers of (GWI) in 1991 veterans. symptoms GWI include fatigue, pain, cognitive problems, gastrointestinal, respiratory, and skin problems. Neurotoxicant exposures during deployment, such as pesticides, sarin, pyridostigmine bromide pills have been identified contributors GWI. We also found an association between mild traumatic brain injury (mTBI) increased rates However, the combined impact these physical chemical...
About 14% of veterans who suffer from Gulf war illness (GWI) complain some form gastrointestinal disorder but with no significant markers clinical pathology. Our previous studies have shown that exposure to GW chemicals resulted in altered microbiome which was associated damage molecular pattern (DAMP) release followed by neuro and inflammation loss gut barrier integrity. Enteric glial cells (EGC) are emerging as important regulators the tract been observed change a reactive phenotype...
Neurological disorders are commonly reported among veterans who returned from the Gulf war. Veterans suffer War illness (GWI) complain of continued symptom persistence that includes neurological disorders, muscle weakness, headaches, and memory loss, developed during or shortly after Our recent research showed chemical exposure associated microbial dysbiosis accompanied by a leaky gut connected pathologies in intestine, liver, brain. However, mechanisms caused symptoms to persist even 30...
This paper provides a strategy for the assessment of brain function in longitudinal cohort studies children. The proposed invokes both domain-specific and omnibus intelligence test approaches. In order to minimise testing burden practice effects, is divided into four groups with one-quarter tested at 6-monthly intervals 0-2-year age range (at ages 6 months, 1.0, 1.5 2.0 years) annual from 3-20 (one-quarter children 3, another 4, etc). allows investigation cognitive development relationship...
Prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (PCE) have shown increases in the risk certain congenital anomalies among exposed offspring. This retrospective cohort study examined whether PCE contamination public drinking water supplies Massachusetts influenced occurrence children whose mothers were around time conception. The included 1,658 PCE-contaminated a comparable group 2,999 unexposed mothers. Mothers completed self-administered...
Many studies of adults with acute and chronic solvent exposure have shown adverse effects on cognition, behavior mood. No prior study has investigated the long-term impact prenatal early childhood to tetrachloroethylene (PCE) affinity for risky behaviors, defined as smoking, drinking or drug use a teen adult. This retrospective cohort examined whether life PCE-contaminated water influenced occurrence cigarette alcohol consumption, among from Cape Cod, Massachusetts. Eight hundred thirty-one...
While many studies of adults with solvent exposure have shown increased risks anxiety and depressive disorders, there is little information on the impact prenatal early childhood subsequent risk mental illness. This retrospective cohort study examined whether life to tetrachloroethylene (PCE)-contaminated drinking water influenced occurrence depression, bipolar disorder, post-traumatic stress schizophrenia among from Cape Cod, Massachusetts. A total 1,512 subjects born between 1969 1983 were...
Recent research demonstrated a relation between traumatic brain injury (TBI), health symptoms and diagnosis of Gulf War Illness (GWI) in Veterans, but no study has examined the impact multiple mild TBIs (mTBIs). A total 229 male Veterans from Ft Devens Cohort were categorized by number mTBIs reported. One-way ANOVA chi-square test independence used to for differences reported chronic multisymptom illness (CMI) or Kansas GWI criteria, two most common case definitions GWI. 72 veterans (31.4%),...
Persistence of Gulf War illness (GWI) pathology among deployed veterans is a clinical challenge even after almost three decades. Recent studies show higher prevalence obesity and metabolic disturbances primarily due to the existence post-traumatic stress disorder (PTSD), chronic fatigue, sedentary lifestyle, consumption high-carbohydrate/high-fat diet. We test hypothesis that from Western-style diet alters host gut microbial species worsens gastrointestinal neuroinflammatory symptom...
The Boston University-based Gulf War Illness Consortium (GWIC) is a multidisciplinary initiative developed to provide detailed understanding of brain and immune alterations that underlie illness (GWI), the persistent multisymptom disorder associated with military service in 1990-1991 War. core GWIC case-control clinical study conducted in-depth evaluation 269 veterans (223 GWI cases, 46 controls) at three U.S. sites included assessments, imaging, neuropsychological testing, analyses broad...
While adult exposure to PCE is known have toxic effects, there little information on the long-term impact of prenatal and early childhood exposure. We undertook a retrospective cohort study examine effects their life PCE-contaminated drinking water. This examined whether water influenced risk variety chronic conditions among adults who were born between 1969 1983 in Cape Cod area Massachusetts. Eight hundred thirty-one participants with 547 unexposed studied. Individuals completed...
BACKGROUND: Workers in the animal slaughter and processing industry United States experience high rates of occupational injury as well stressful work conditions, yet mental health this workforce remains largely unstudied. OBJECTIVE: To a
The 1991 Persian Gulf War veterans presented a myriad of symptoms that ranged from chronic pain, fatigue, gastrointestinal disturbances, and cognitive deficits. Currently, no therapeutic regimen exists to treat the plethora though newer pharmacological targets such as microbiome have been identified recently. Toll-like receptor 4 (TLR4) antagonism in systemic inflammatory diseases tried before with limited success, but strategies broad-spectrum TLR4 antagonists their ability modulate...