A5028138377- Air Quality and Health Impacts
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Environmental Justice and Health Disparities
- Health disparities and outcomes
- Data-Driven Disease Surveillance
- Global Cancer Incidence and Screening
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Spatial and Panel Data Analysis
- Urban Transport and Accessibility
- Ovarian cancer diagnosis and treatment
- Prenatal Substance Exposure Effects
- SARS-CoV-2 and COVID-19 Research
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Water Treatment and Disinfection
- Respiratory viral infections research
- Noise Effects and Management
- Colorectal Cancer Screening and Detection
- Atmospheric chemistry and aerosols
- Statistical Methods and Bayesian Inference
- Autism Spectrum Disorder Research
- Carcinogens and Genotoxicity Assessment
- Energy and Environment Impacts
University of California, Irvine
2015-2025
Samueli Institute
2018-2025
UC Irvine Health
2025
Community Cancer Center
2020-2024
University of California, Irvine Medical Center
2023
Irvine University
2014-2022
Boston University
2006-2020
Irvine Valley College
2020
Community Link
2020
State University of Norte Fluminense
2018-2019
The C8 Health Project was created, authorized, and funded as part of the settlement agreement reached in case Jack W. Leach, et al. v. E.I. du Pont de Nemours & Company (no. 01-C-608 W.Va., Wood County Circuit Court, filed 10 April 2002). stemmed from perfluorooctanoic acid (PFOA, or C8) contamination drinking water six districts two states near DuPont Washington Works facility Parkersburg, West Virginia.This study reports on methods results Project, a population created to gather data that...
Background: Perfluorooctanoic acid (PFOA) has been linked to cancer in occupational mortality studies and animal toxicologic research.Objective: We investigated the relationship between PFOA exposure among residents living near DuPont Teflon-manufacturing plant Parkersburg, West Virginia (WV).Methods: Our analyses included incident cases of 18 cancers diagnosed from 1996 through 2005 five Ohio (OH) counties eight WV counties. For each outcome, controls comprised all other study data set...
BackgroundPolyfluoroalkyl chemicals (PFCs) have been widely used in consumer products. Exposures the United States and world populations are widespread. PFC exposures linked to various health impacts, data animals suggest that PFCs may be potential developmental neurotoxicants.ObjectivesWe evaluated associations between four parental report of diagnosis attention deficit/hyperactivity disorder (ADHD).MethodsData were obtained from National Health Nutrition Examination Survey (NHANES)...
Perfluorooctanoic acid (PFOA) has been detected in environmental samples Ohio and West Virginia near the Washington Works Plant Parkersburg, Virginia. This paper describes retrospective fate transport modeling of PFOA concentrations local air, surface water, groundwater, six municipal water systems based on estimates historic emission rates from facility, physicochemical properties PFOA, geologic meteorological data beginning 1951. We linked several to model air dispersion, transit through...
BackgroundThe C8 Health Project was established in 2005 to collect data on perfluorooctanoic acid (PFOA, or C8) and human health Ohio West Virginia communities contaminated by a fluoropolymer production facility.ObjectiveWe assessed PFOA exposure via drinking water subset of participants who drank from private wells.MethodsParticipants provided demographic information residential, occupational, medical histories. Laboratory analyses were conducted determine serum-PFOA concentrations....
Serum levels of perfluorooctanoic acid (PFOA) have been associated with decreased renal function in cross-sectional analyses, but the direction association is unclear. We examined measured and model-predicted serum PFOA concentrations estimated glomerular filtration rate (eGFR), a marker kidney function, highly exposed population (median PFOA, 28.3 ng/mL). creatinine, perfluorooctane sulfonate (PFOS), perfluorononanoic (PFNA), perfluorohexane (PFHxS) calculated eGFR 9,660 children 1 to < 18...
Perfluorooctanoic acid (PFOA) is considered a probable human carcinogen by the U.S. Environmental Protection Agency. It does not exist in nature but has been used widely since World War II. present serum of most Americans at about 4-5 ng/mL, although routes exposure remain unknown.We examined predictors PFOA mid-Ohio Valley residents living near chemical plant that until recently released large quantities into environment, contaminating drinking water.We studied 69,030 six contaminated water...
The carcinogenicity of perfluorooctanoic acid (PFOA) has been reviewed previously by several different regulatory agencies and researchers, with contradictory conclusions-especially regarding epidemiological findings on kidney cancer testicular cancer. In addition, previous dose-response assessments have focused primarily evidence from animal studies. This critical review summarizes peer studies PFOA cancers the kidneys testes, using modified Hill's criteria to assess for causation. We...
We aimed to investigate the role of indoor office air on exposure polyfluorinated compounds (PFCs) among workers. Week-long, active sampling was conducted during winter 2009 in 31 offices Boston, MA. Air samples were analyzed for fluorotelomer alcohols (FTOHs), sulfonamides (FOSAs), and sulfonamidoethanols (FOSEs). Serum collected from each participant (n = 31) 12 PFCs including PFOA PFOS. In air, FTOHs present highest concentrations, particularly 8:2-FTOH (GM 9920 pg/m(3)). varied...
People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities.Our objective was estimate historical PFOA exposures serum concentrations experienced 45,276 non-occupationally participants the C8 Health Project who consented share their residential histories a 2005-2006 measurement.We estimated annual exposure rates for each individual based on predicted calibrated water air using an...
In 1988, elevated cancer incidence in upper Cape Cod, Massachusetts prompted a large epidemiological study of nine cancers to investigate possible environmental risk factors. Positive associations were observed, but explained only portion the excess incidence. This case-control provided detailed information on individual-level covariates and residential history that can be spatially analyzed using generalized additive models (GAMs) geographical systems (GIS). We investigated association...
Perfluorooctanoic acid (PFOA) is a potential cause of adverse pregnancy outcomes, but previous studies have been limited by low exposures and small study size. Using birth certificate information, we examined the relation between estimated PFOA exposure outcomes in an area West Virginia Ohio whose drinking water was contaminated chemical plant. Births from 1990 through 2004 were to generate case groups stillbirth (n = 106), pregnancy-induced hypertension 224), preterm 3,613), term weight...
The etiology of rheumatoid arthritis (RA) remains largely unknown, although epidemiologic studies suggest genetic and environmental factors may play a role. Geographic variation in incident RA has been observed at the regional level.
There is increasing concern that environmental exposures, such as air pollution, may be related to rates of breast cancer; however, results from cohort studies have been mixed. We examined the association between particulate matter (PM) and measures distance roadway with risk incident cancer in prospective nationwide Nurses' Health Study II (NHSII) cohort.Incident invasive 1993 2011 (N = 3,416) was assessed among 115,921 women NHSII cohort. Time-varying Cox proportional hazards models were...
Abstract Clinic-based estimates of SARS-CoV-2 may considerably underestimate the total number infections. Access to testing in US has been heterogeneous and symptoms vary widely infected persons. Public health surveillance efforts metrics are therefore hampered by underreporting. We set out provide a minimally biased estimate seroprevalence among adults for large diverse county (Orange County, CA, population 3.2 million). implemented study that minimizes response bias recruiting answer...
Mapping spatial distributions of disease occurrence and risk can serve as a useful tool for identifying exposures public health concern. Disease registry data are often mapped by town or county diagnosis contain limited on covariates. These maps possess poor resolution, the potential confounding, inability to consider latency. Population-based case-control studies provide detailed information residential history Generalized additive models (GAMs) framework mapping point-based epidemiologic...
The availability of geographic information from cancer and birth defect registries has increased public demands for investigation perceived disease clusters. Many neighborhood-level cluster investigations are methodologically problematic, while maps made registry data often ignore latency many known risk factors. Population-based case-control cohort studies provide a stronger foundation spatial epidemiology because potential confounders can be addressed. We investigated the association...
BackgroundPrevious research demonstrated increased risk of breast cancer associated with higher socioeconomic status (SES) measured at both the individual and community levels. However, little attention has been paid to simultaneously examining measures.ObjectivesWe evaluated independent influences SES on using case–control data. Because our previous work suggests that associations may be stronger after including a latency period, we also assessed effect community-level assuming 10-year...