A5027933896- Myasthenia Gravis and Thymoma
- Inflammatory Myopathies and Dermatomyositis
- Dementia and Cognitive Impairment Research
- Intracranial Aneurysms: Treatment and Complications
- Autoimmune and Inflammatory Disorders
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Peripheral Neuropathies and Disorders
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Cerebrospinal fluid and hydrocephalus
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cerebrovascular and Carotid Artery Diseases
- Gestational Trophoblastic Disease Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunodeficiency and Autoimmune Disorders
- Neurological and metabolic disorders
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Botulinum Toxin and Related Neurological Disorders
National Health Insurance Service
2013-2024
National Health Insurance Service Ilsan Hospital
2015-2024
The University of Texas MD Anderson Cancer Center
2000-2022
Jeonbuk National University
2021
University of Miami
2018-2020
Marconi University
2019
Pusan National University Hospital
2012-2018
Kangwon National University
2017
Yonsei University
2015
Alzheimer's Drug Discovery Foundation
2014
Objective: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) can be an alternative treatment option for intractable epilepsy patients. Since CM may involved in widespread cortico-subcortical networks, identification cortical sub-networks specific to target stimuli provide further understanding on underlying mechanisms DBS. Several structures have distinguishing connections that related pivotal propagation and subsequent clinical effect Methods: To explore core their...
Background The prevalence and incidence of Parkinson`s disease (PD) are important for supporting the better comprehension aspects helping public health planning. Our aim is to evaluate in South Korea between 2004 2013. Methods This retrospective, nationwide, longitudinal population-based study used National Health Insurance Service-National Sample Cohort Database define patients with PD from 2013 based on having Korean Classification Diseases code G20, which were assigned by neurologists,...
Neurofilaments (NFs) including neurofilament‑200 kDa (NF‑H), neurofilament‑165 (NF‑M) and neurofilament‑68 (NF‑L) are major protein constituents of the brain, serve important roles in regulation axonal transport. NF alteration is a key feature pathogenesis neurological disorders involving cognitive dysfunction. In present study, impairments were investigated, via assessments using Morris water maze passive avoidance tests, mice following chronic systemic treatment with 1 mg/kg scopolamine...
To understand the characteristics of Korean patients with anti-3-hydroxy-3-methylglutaryl-coenxyme A reductase (HMGCR) myopathy, we measured anti-HMGCR antibodies and analyzed clinical, radiological, pathological features myopathy.We titers in sera 99 inflammatory 36 genetic 63 healthy subjects using an enzyme-linked immunosorbent assay. We tested 16 myositis-specific autoantibodies (MSAs) all myopathy.Positivity for antibody was observed 17 (4 males 13 females) myopathy. The median age at...
An increased risk of sarcoidosis and sarcoid-like reactions in subjects with a history malignancy has been suggested. We assessed the incidence clinical characteristics cancer patients biopsies containing granulomas on metastasis patient survival.This is retrospective, multicentre, observational study involving endobronchial ultrasound transbronchial needle aspiration melanoma dataset at University Miami, USA, database Chiba University, Japan. Subjects confirmed diagnosis who subsequently...
Mutations in the Dynactin 1 (DCTN1) gene have been demonstrated to result various neurodegenerative diseases, including distal hereditary motor neuropathy type 7B (dHMN7B), Perry syndrome, amyotrophic lateral sclerosis and sclerosis‑frontotemporal dementia. However, since first dHMN7B patient with a DCTN1 mutation was described 2003, best of our knowledge no further cases reported. In present study, p.G59S identified two unrelated families from total 24 Korean dHMN, by whole exome...
During the coronavirus disease 2019 (COVID-19) pandemic, patients with myasthenia gravis (MG) were more susceptible to poor outcomes owing respiratory muscle weakness and immunotherapy. Several studies conducted in early stages of COVID-19 pandemic reported higher mortality MG compared general population. This study aimed investigate clinical course prognosis compare these parameters between vaccinated unvaccinated South Korea.
Pulmonary extrauterine epithelioid trophoblastic tumors (ETTs) are extremely rare. A 26-year-old nonsmoking woman with a history of suspected subclinical miscarriage presented large mass in the right lower lobe that was confirmed to be pulmonary ETT using immunohistochemical stains. When fertile presents and an elevated serum β-human chorionic gonadotrophin absence gynecologic disease, should considered.
Isolated middle cerebral artery (MCA) stenosis in young patients with no other medical condition may be a unique pathologic entity benign long-term course. Generally, moyamoya disease shows progression of from internal (ICA) to intracranial vessel. A 26-year-old woman was admitted for choreic movements the right arm and leg. Brain magnetic resonance imaging showed stroke. Conventional angiography revealed 48% left M1 without ICA stenosis. Single photon emission computed tomography perfusion...
Patients with amnestic mild cognitive impairment (aMCI) are considered to have a high risk for Alzheimer dementia (AD). Even positive predictive values, however, cannot be guaranteed even by tests sensitivity and specificity when disease prevalence is low. If we regard the clinical criteria aMCI as test predicting due AD, value of will low definition in young patients (age below 65 years) because AD this age group. To hypothesis, compared CSF biomarkers between old years or older) groups...
The effective management of chronic tuberculous empyema requires an evacuation pus and a re-expansion the lung or obliteration space such as closed thoracostomy, decortication, open window thoracostomy (OWT) followed by intrathoracic muscular transposition (IMT). However, most is still debatable.From June 1999 to July 2010, 18 patients with who underwent OWT and/or IMT were enrolled in this study. causes empyema, methods outcomes treatment retrospectively reviewed. success rate was...
Background In patients with parapneumonic empyema, decortication is usually preferred to ensure functional lung re-expansion. However, there could be exhibiting incomplete postoperative expansion and inadequate drainage despite decortication. Therefore, we evaluated factors affecting in undergoing Methods A total of 221 pyogenic empyema who underwent video-assisted thoracoscopic surgery (VATS) between January October 2016 our hospital were reviewed terms surgical success. The following...
Hypothermic treatment is known to protect against cardiac arrest (CA) and improve survival rate. However, few studies have evaluated the CA‑induced liver damage effects of hypothermia on this damage. Therefore, aim present study was determine possible protective after asphyxial CA. Rats were subjected a 5‑min CA followed by return spontaneous circulation (ROSC). The body temperature controlled at 37±0.5˚C (normothermia group) or 33±0.5˚C (hypothermia for 4 h ROSC. Livers examined 6, 12 h, 1...
Nociplastic pain refers to arising from altered nociception without evidence of tissue or somatosensory damage. It encompasses various clinical conditions with shared neurophysiological mechanisms involving different organ systems. can occur independently alongside chronic a nociceptive neuropathic origin. This review introduces the concept nociplastic pain, its manifestations and underlying pathophysiology. Taking biopsychosocial approach lead better understanding improved treatment...
Peripheral neuropathy or amyotropic lateral sclerosis can be associated with renal cell carcinoma. We report a 63-year-old male patient carcinoma who developed an atypical, progressive after nephrectomy.
Background: Takotsubo syndrome and myasthenic crisis can be triggered by physical stress. We present the case of a woman who developed following radiocontrast media-induced anaphylaxis.Case Report: A 39-year-old presented with diplopia ptosis. After chest computed tomography scan, her consciousness was stupor oxygen saturation decreased. Electrocardiography showed ST elevation, cardiac enzyme levels increased. Echocardiography revealed severe left ventricular dysfunction. Myasthenia gravis...
서 론뇌내출혈 후의 발작은 4.6-18%에서 나타나며, 뇌내출혈의 크기, 위치와 피질의 침범 여부에 따라 빈도가 다르다. 1,2심부출혈에서는 내엽출혈과 비교하여 발작의 더 낮다고 알려져 있고, 뇌전증지속증의 빈도는 더욱 낮다.뇌내출혈, 특히 심부출혈은 수 술적 치료가 효과적이지 못한 것으로 있다.하지만 일부 연구에 의하면 도관삽 입과 출혈배액 등이 혈종의 크기를 줄이는데 도움이 되는