A5101536664- Nutritional Studies and Diet
- Dementia and Cognitive Impairment Research
- Diverse Approaches in Healthcare and Education Studies
- Cyclone Separators and Fluid Dynamics
- Frailty in Older Adults
- Healthcare and Venom Research
- Advanced Computational Techniques in Science and Engineering
- Alzheimer's disease research and treatments
- Histone Deacetylase Inhibitors Research
- Cholinesterase and Neurodegenerative Diseases
- Health and Wellbeing Research
- Education and Learning Interventions
- Educational Systems and Policies
- Clinical practice guidelines implementation
- Educational Research and Pedagogy
- Technology and Data Analysis
Seoul St. Mary's Hospital
2019-2020
Catholic University of Korea
2019-2020
Abstract Alzheimer's disease (AD) is an age‐related neurodegenerative disease. The most common pathological hallmarks are amyloid plaques and neurofibrillary tangles in the brain. In brains of patients with AD, tau abnormally accumulated causing neuronal loss, synaptic dysfunction, cognitive decline. We found a histone deacetylase 6 (HDAC6) inhibitor, CKD‐504, changed interactome dramatically to degrade not only AD animal model (ADLP APT ) containing both but also patient‐derived brain...
Objectives The present study examined self‐reports and informant reports of cognitive function discrepancies between the two reporting methods in healthy controls (HC), subjective decline (SCD), mild impairment (MCI), very Alzheimer disease (AD) using three questionnaires. Methods included a total 300 individuals (mean age: 74.4 ± 5.7 y), including 130 HC, 70 SCD, 51 MCI, 49 AD patients. Self‐ratings ratings were assessed Korean Dementia Screening Questionnaire‐Cognition (KDSQ‐C), AD8,...
Background: Korea has a periodic general health check-up program that uses the Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) as cognitive dysfunction screening tool.The Alzheimer Disease 8 (AD8) and Subjective Memory Complaints Questionnaire (SMCQ) are also used in clinical practice.We compared diagnostic ability of these questionnaires for impairment when completed by participants their caregivers.Hence, we aimed to evaluate whether SMCQ or AD8 is superior KDSQ-C can be its...
Background and PurposeWe aimed to determine the reliability validity of a short form Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) as screening tool for cognitive dysfunction.Methods This study recruited 420 patients older than 65 years their informants from 11 hospitals, categorized into normal cognition, mild impairment, dementia subgroups.The KDSQ-C was completed separately by informants.We abstracted three components combined these following four subscales: KDSQ-C-I (items...
Abstract Horizontal-Flow Roughing Filtration (HRF) is an alternative pretreatment method e.g. prior to Slow Sand (SSF). However, some of its limitations are that the effluent quality drops drastically at higher turbidity (>200NTU) and filtration rate (>1m h−1). To overcome these drawbacks, we suggested Direct (DHRF), which a modified system by addition low dose coagulant filtration. optimize DHRF configuration, conceptual mathematical model for coarse compartment has been developed in...
본 연구의 목적은 예비교사들의 집단지성을 활용한 글쓰기활동을 통해 과학지식 형성과정을 탐색하는 것이다. 이를 위하여 과학논리논술 전공수업을 수강하는 29명의 대학생들을 대상으로 적정기술이라는 과학주제를 제시하여 이에 대한 지식의 탐색하였다. 이 활동은 학생들의 자유로운 참여와 쌍방향 커뮤니케이션을 위해 온라인상에서 진행되었으며, 모든 학생들이 충분히 자신의 의견을 표현하고, 다른 정보를 판단할 수 있도록 한 달이라는 기간 동안 실시되었다. 참여방식은 학생이 관련 제시하면 다음 학생은 기존정보를 읽고 자신이 원하는 조합 및 수정하여 제시하는 것으로 실시되었으며 참여횟수는 제한하지 않았다. 또한 질문지를 참여자가 해당 글을 수정하거나 추가한 이유를 기술하도록 하였다. 연구결과 학생들은 크게 4단계의 과정을 집단적 과학지식을 형성해 나가는 나타났다. 첫 번째 단계는 정보가 팽창하는 단계이며, 두 가치정보가 축적되기 시작하는 단계이다. 세 논리 비판적 사고단계이며, 마지막으로...