A5100630256- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Spine and Intervertebral Disc Pathology
- Balance, Gait, and Falls Prevention
- Optical Imaging and Spectroscopy Techniques
- Spinal Fractures and Fixation Techniques
- Total Knee Arthroplasty Outcomes
- Diverse Approaches in Healthcare and Education Studies
- Dysphagia Assessment and Management
- Neuropeptides and Animal Physiology
- Pain Management and Treatment
- Shoulder Injury and Treatment
- Musculoskeletal pain and rehabilitation
- Receptor Mechanisms and Signaling
- Pelvic and Acetabular Injuries
- Motor Control and Adaptation
- Hip disorders and treatments
- Cardiovascular and exercise physiology
- Effects of Vibration on Health
- Foot and Ankle Surgery
- Cerebral Palsy and Movement Disorders
- Endoplasmic Reticulum Stress and Disease
- Medical Imaging and Analysis
- Sports Performance and Training
Institute for Basic Science
2023-2025
Seoul National University
2018-2025
Yonsei University
2025
Namseoul University
2025
Incheon Medical Center
2013-2024
Wooridul Hospital
2011-2024
Sungkyunkwan University
2019-2023
Samsung (South Korea)
2019-2023
Samsung Medical Center
2020-2022
Korea Institute of Civil Engineering and Building Technology
2012-2018
Neuropeptide Y (NPY) is highly abundant in the brain and involved various physiological processes related to food intake anxiety, as well human diseases such obesity cancer. However, molecular details of interactions between NPY its receptors are poorly understood. Here, we report a cryo-electron microscopy structure NPY-bound neuropeptide Y1 receptor (Y1R) complex with Gi1 protein. The C-terminal segment forming extended conformation binds deep into Y1R transmembrane core, where amidated...
Abstract Low-density lipoprotein receptor-related protein 6 (LRP6) is a coreceptor of the β-catenin-dependent Wnt signaling pathway. The LRP6 ectodomain binds proteins, as well inhibitors such sclerostin (SOST), which negatively regulates in osteocytes. Although 1 (E1) known to interact with SOST, several unresolved questions remain, reason why SOST E1E2 higher affinity than E1 domain alone. Here, we present crystal structure E1E2–SOST complex two interaction sites tandem. unexpected...
Abstract Structural and mechanistic studies on human odorant receptors (ORs), key in olfactory signaling, are challenging because of their low surface expression heterologous cells. The recent structure OR51E2 bound to propionate provided molecular insight into recognition, but the lack an inactive OR limited understanding activation mechanism ORs upon binding. Here, we determined cryo-electron microscopy structures consensus OR52 (OR52 cs ), a representative family, ligand-free (apo)...
Background context. Proximal junctional kyphosis (PJK) following surgical treatment of lumbar degenerative (LDK) is one the critical complications leading to failure instrumentation and additional extensive surgery. However, most previous studies have focused on idiopathic scoliosis resulting from variable techniques. LDK usually differ other scoliotic deformities in terms patient characteristics disease mechanisms. Purpose. Identification prevalence PJK after searching for predictable value...
Significance Wnt signaling has a broad spectrum of effects on cellular physiology and diseases like cancer. Much the specificity regulation mechanism Frizzled (Fzd) family, main receptor pathway, remains elusive, but exploiting activation Fzd is pivotal to understanding pathway. Here, by using biophysical biochemical techniques, we identify key conformational changes that occur as Norrin ligand binds Fzd4, show functional implications involved regions. We also reveal linker region plays an...
With increasing age, individuals are more likely to experience physical disabilities, functional declines, and mobility limitations. Wearable robots or exoskeletons relatively new technologies that can help address these issues, reduce healthcare costs, support home healthcare, decreasing the burden of chronic disease. The purpose this study was investigate usability Bot Fit after task-specific activities gait training, as well examine effects a wearable hip exoskeleton, Fit, on gait,...
Abstract Neuropeptide FF Receptor 2 (NPFFR2), a G-protein-coupled receptor, plays role in pain modulation and diet-induced thermogenesis. While NPFFR2 is strongly activated by neuropeptides (NPFFs), it shows low activity response to RF-amide-related peptides (RFRPs), despite the belonging shared family. In contrast, NPFFR1, which shares high sequence similarity with NPFFR2, RFRPs regulates reproductive hormone balance. The molecular basis for these receptor-specific interactions their...
Abstract The complement system plays crucial roles in innate immunity and inflammatory responses. anaphylatoxin C3a mediates pro-inflammatory chemotactic functions through the G protein-coupled receptor C3aR. While active structure of C3a-C3aR-G i complex has been determined, inactive conformation activation mechanism C3aR remain elusive. Here we report cryo-EM ligand-free, protein-free C3aR, providing insights into its conformation. In addition, determine structures with synthetic...
The objective and scope of this Limited Output Transcranial Electrical Stimulation 2023 (LOTES-2023) guidance is to update the previous LOTES-2017 guidance. These documents should therefore be considered together. LOTES provides a clearly articulated transparent framework for design devices providing limited output (specified low-intensity range) transcranial electrical stimulation variety intended uses. guidelines can inform trial regulatory decisions, but most directly manufacturer...
The objective of this study was to evaluate whether Cerebrolysin combined with rehabilitation therapy supports additional motor recovery in stroke patients severe impairment. This analyzed the data from two phase IV prospective, multicenter, randomized, double-blind, placebo-controlled trials. Stroke were included within seven days after onset and randomized receive a 21-day treatment course either or placebo standardized therapy. Assessments performed at baseline, immediately course, 90...
Introduction Alzheimer’s disease (AD), the most common form of dementia, is characterized by progressive cognitive decline. To address this, we conducted a randomized, double-blinded, sham-controlled study to investigate therapeutic potential transcranial direct current stimulation (tDCS) on patients with amyloid positron emission tomography (PET)- positive AD. Methods Participants already undergoing pharmacological treatment and testing for PET were divided into Active-tDCS ( n = 8)...
Background Gait problems are critical impairments in Parkinson's disease (PD) and related to increased risk of fall negatively impact activities daily life. Transcranial direct current stimulation (tDCS) is a non-invasive brain technique that can modify the cortical excitability gait-related regions. In this study, we investigated whether multichannel tDCS with simultaneous treadmill gait training could improve PD. Methods Twenty-four patients PD were assigned randomly real or sham group....
High-definition transcranial direct current stimulation (HD-tDCS) has recently been proposed as a tDCS approach that can be used on specific cortical region without causing undesirable effects. In this uncontrolled pilot study, the hemodynamic changes caused by HD-tDCS applied over ipsilesional motor area were investigated in 26 stroke patients. using one anodal and four cathodal electrodes at 1 mA was administered for 20 min to C3 or C4 daily sessions. Cortical activation measured...
Gait is a complex behavior that involves not only the musculoskeletal system, but also higher-order brain functions, including cognition. This study was performed to investigate correlation between lower limb muscle activity and cortical activation during treadmill walking in two groups of elderly people: young-old (aged 65-74 years) old-old 75-84 years).Thirty-one 31 people participated this study. All participants were sequentially subjected three gait conditions on treadmill: (1)...
Physical inactivity and sedentary behavior both increase the risk of chronic disease mortality. Regular participation in physical activity reducing play important roles maintaining health prevention.
[Purpose] The purpose of this study was to compare the strength and endurance orbicularis oris muscle in healthy Korean (young vs. elderly adults). [Participants Methods] A total 60 participants (30 young adults 30 adults) were recruited. Iowa Oral Performance Instrument used measure maximal endurance. [Results] Elderly showed significantly lower than younger adults. [Conclusion] This confirmed a significant age-related decrease data collected will be useful as basis for future on speech...
Background. Various prognostic biomarkers for upper extremity (UE) motor recovery after stroke have been reported. However, most relatively low predictive accuracy in severe patients.Objective. This study suggests an imaging biomarker-based model effectively predicting UE patients.Methods. Of 104 ischemic patients screened, 42 with impairment were included. All underwent structural, diffusion, and functional magnetic resonance at 2 weeks function assessments 3 months onset. According to...
Sacral fractures in elderly patients with associated lumbosacral lesions can be overlooked easily because of vague symptoms and delayed neurological insufficiency. A 70-year-old female a 73-year-old presented insufficiency caused by transverse sacral fracture after minor trauma. Both had suffered from lower extremity dysuresia dyschezia for more than month. Coexisting pathological may confuse the correct diagnosis fractures. Decompressive laminectomy was performed, showed relatively...
In the elderly, walking while simultaneously engaging in other activities becomes more difficult. This study aimed to examine changes cortical activity during with aging. We try reveal effects of an additional task and increased speed on activation young-old old-old elderly. Twenty-seven (70.2 ± 3.0 years) 23 (78.0 2.3 participated this study. Each subject completed four tasks treadmill, a 2 × design; two single-task (ST) conditions self-selected (SSWS) fast (FWS), dual-task (DT) SSWS FWS....