A5014833038- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Health and Wellbeing Research
- Diverse Approaches in Healthcare and Education Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Health, Environment, Cognitive Aging
- Coenzyme Q10 studies and effects
- Stroke Rehabilitation and Recovery
- Service-Oriented Architecture and Web Services
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Virtual Reality Applications and Impacts
- Cholinesterase and Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Pharmacy and Medical Practices
- Functional Brain Connectivity Studies
- Software Engineering Techniques and Practices
- Educational Reforms and Innovations
- COVID-19 and Mental Health
- Neurogenesis and neuroplasticity mechanisms
- Click Chemistry and Applications
- Web Data Mining and Analysis
- Advanced Software Engineering Methodologies
Korea Advanced Institute of Science and Technology
2010-2025
Hanyang University
2015-2024
Hanyang University Guri Hospital
2014-2024
Chonnam National University
2024
Korea University
2024
Weatherford College
2022
Ewha Womans University
2003-2019
Jeju National University Hospital
2019
Kyungpook National University
2019
Kyungpook National University Medical Center
2019
Tubulin polymerization inhibitors had emerged as one of promising anticancer therapeutics because their dual mechanism action, i.e. apoptosis by cell-cycle arrest and VDA, vascular disrupting agent. VDAs are believed to be more efficient, less toxic, several them currently undergoing clinical trials. To identify novel tubulin that possess potent cytotoxicity strong inhibition well in vivo antitumor efficacy, we have utilized benzophenone scaffold. Complete SAR analysis newly synthesized...
Early detection of mild cognitive impairment (MCI), a transitional stage between normal aging and Alzheimer disease, is crucial for preventing the progression dementia. Virtual reality (VR) biomarkers have proven to be effective in capturing behaviors associated with subtle deficits instrumental activities daily living, such as challenges using food-ordering kiosk, early MCI. On other hand, magnetic resonance imaging (MRI) demonstrated their efficacy quantifying observable structural brain...
Abstract Aberrant fibroblast growth factor receptor (FGFR) activation/expression is a common feature in lung cancer (LC). In this study, we evaluated the antitumor activity of and mechanisms underlying acquired resistance to two potent selective FGFR inhibitors, AZD4547 BAY116387, LC cell lines. The BAY1163877 was screened 24 lines, including 5 with FGFR1 amplification. Two lines containing amplifications, H1581 DMS114, were sensitive inhibitors (IC 50 <250 n m ). Clones -amplified cells...
Aim The aim of the present study was to evaluate efficacy a multidomain program in patients with A lzheimer's disease ( AD ). Methods total 53 probable participated study. participants were classified cognitive programming group n = 32) and control 21). Participants intervention received stimulation including art, music, recollection horticultural therapy, each period lasting 1 h. This repeated five times per week over 6 months at S eongdong‐gu C enter for D ementia. M ini‐ ental tate E...
Questionnaires or computer-based tests for assessing activities of daily living are well-known approaches to screen mild cognitive impairment (MCI). However, questionnaires subjective and computerized only collect simple performance data with conventional input devices such as a mouse keyboard. This study explored the validity discriminative power virtual test new diagnostic approach assess MCI. Twenty-two healthy controls 20 patients MCI were recruited. The presents two complex tasks in an...
Transfer learning leverages the abundance of English data to address scarcity resources in modeling non-English languages, such as Korean. In this study, we explore potential Phrase Aligned Data (PAD) from standardized Statistical Machine Translation (SMT) enhance efficiency transfer learning. Through extensive experiments, demonstrate that PAD synergizes effectively with syntactic characteristics Korean language, mitigating weaknesses SMT and significantly improving model performance....
Background Cognitive impairment is associated with a negative prognosis in amyotrophic lateral sclerosis (ALS), as well clinical specificity. We investigate neuropsychological function ALS patients without known genetic mutations Korean tertiary clinic. Methods Three hundred and eighteen were enrolled prospective longitudinal cohort from September 2008 to February 2012. At the time of diagnosis sporadic ALS, we carried out comprehensive tests on all patients, collected demographic...
Background With the global rise in Alzheimer disease (AD), early screening for mild cognitive impairment (MCI), which is a preclinical stage of AD, paramount importance. Although biomarkers such as cerebrospinal fluid amyloid level and magnetic resonance imaging have been studied, they limitations, high cost invasiveness. Digital markers to assess by analyzing behavioral data collected from digital devices daily life can be new alternative. In this context, we developed “virtual kiosk test”...
Neurogenesis in the adult brain is important for memory and learning, alterations neural stem cells (NSCs) may be an part of Alzheimer's disease pathogenesis. The phosphatidylinositol 3-kinase (PI3K) pathway has been suggested to play role neuronal cell survival highly involved neurogenesis. Recently, coenzyme Q10 (CoQ10) was found affect PI3K pathway. We investigated whether CoQ10 could restore amyloid β (Aβ)25-35 oligomer-inhibited proliferation NSCs by focusing on To evaluate effects...
Alzheimer's disease (AD) causes a rapid deterioration in cognitive and physical functions, including problem-solving, memory, language, daily activities. Mild impairment (MCI) is considered risk factor for AD, early diagnosis treatment of MCI may help slow the progression AD. Electroencephalography (EEG) analysis has become an increasingly popular tool developing biomarkers AD diagnosis. Compared with healthy elderly, patients showed very clear differences EEG patterns, but it inconclusive...
By the number of people aged 60 or over and with disabilities growing, homecare mobile robot draws increasing attention. However, there are challenges autonomous navigation for such as frequent changes environment, obstacles goal position. In this paper, we focus on verifying potential neural network-based mobile. And compare recurrent network multilayer perceptron in an robot. The result suggested that can do better because its capability to handle temporal dependency a data sequence. Also,...
Abstract Amlodipine, a L-type calcium channel blocker, has been reported to have neuroprotective effect in brain ischemia. Mitochondrial overload leads apoptosis of cells neurologic diseases. We evaluated the effects amlodipine camsylate (AC) on neural stem (NSCs) injured by oxygen glucose deprivation (OGD) with focus mitochondrial structure and function. NSCs were isolated from rodent embryonic brains. Effects AC cell viability, proliferation, level free radicals, expression intracellular...
Abstract Objectives This work aimed to compare some pharmacological properties of red ginseng extract (RG) and fermented (FRG). Methods Antinociceptive activity was analysed using the acetic acid-induced abdominal constriction response. Anti-inflammatory evaluated vascular permeability carrageenan-induced inflammation in air pouch, through measurement nitrite content lipopolysaccharide (LPS)-stimulated macrophage cells. Anti-angiogenic determined chick chorioallantoic membrane assay. Key...
Early detection of mild cognitive impairment (MCI) is crucial to impede dementia progression. Virtual reality (VR) biomarkers are adept at detecting impairments in instrumental activities daily living (IADL), whereas magnetic resonance imaging (MRI) excel measuring observable structural changes the brain. However, efficacy integrating VR and MRI improve early MCI remains unclear. This study aims evaluate compare effectiveness investigates potential their combined use for more accurate...