A5001639544- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Mitochondrial Function and Pathology
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Ophthalmology and Eye Disorders
- Healthcare Education and Workforce Issues
- Coenzyme Q10 studies and effects
- Macrophage Migration Inhibitory Factor
- Moyamoya disease diagnosis and treatment
- Job Satisfaction and Organizational Behavior
- Acute Ischemic Stroke Management
- Railway Engineering and Dynamics
- Neurosurgical Procedures and Complications
- Autoimmune Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Advancements in Photolithography Techniques
- Parkinson's Disease Mechanisms and Treatments
- Customer Service Quality and Loyalty
- Cholinesterase and Neurodegenerative Diseases
- Cancer Treatment and Pharmacology
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
Hanyang University Guri Hospital
2016-2025
Hanyang University
2012-2023
Weatherford College
2022
Canadian Wildlife Federation
2012
Sports Concussion Institute
2012
Montreal Neurological Institute and Hospital
2012
Pukyong National University
2010
Korea University
2009-2010
In-Q-Tel
2009
Korea Military Academy
2009
This study aimed to identify differences in the levels of inflammation-related biomarkers between patients with subcortical silent brain infarcts (SBIs) and healthy controls. We also evaluated effect aspirin on SBI inflammatory processes. Consecutive diagnosed SBIs without a history acute stroke were included. The demographic clinical data 26 subjects SBIs, such as number location reviewed. Plasma macrophage migration inhibitory factor (MIF), matrix metalloproteinase-9 (MMP-9), visfatin...
Neurogenesis in the adult brain is important for memory and learning, alterations neural stem cells (NSCs) may be an part of Alzheimer's disease pathogenesis. The phosphatidylinositol 3-kinase (PI3K) pathway has been suggested to play role neuronal cell survival highly involved neurogenesis. Recently, coenzyme Q10 (CoQ10) was found affect PI3K pathway. We investigated whether CoQ10 could restore amyloid β (Aβ)25-35 oligomer-inhibited proliferation NSCs by focusing on To evaluate effects...
Abstract Background Our previous studies showed that GV1001 has various protective effects against β-amyloid and other stressors. Based on these findings, we hypothesized might have beneficial in patients with Alzheimer’s disease (AD). Methods A phase 2, double-blind, parallel-group, placebo-controlled, 6-month randomized clinical trial was performed to evaluate the safety efficacy of subcutaneously administered GV1001. Between September 2017 2019, 13 centers South Korea recruited...
Abstract Amlodipine, a L-type calcium channel blocker, has been reported to have neuroprotective effect in brain ischemia. Mitochondrial overload leads apoptosis of cells neurologic diseases. We evaluated the effects amlodipine camsylate (AC) on neural stem (NSCs) injured by oxygen glucose deprivation (OGD) with focus mitochondrial structure and function. NSCs were isolated from rodent embryonic brains. Effects AC cell viability, proliferation, level free radicals, expression intracellular...
The involvement of matrix metalloproteinases (MMPs) in ischemic-stroke-induced inflammatory response has recently been suggested; however, the relationship between MMPs and stroke progression not evaluated. We investigated role neurological worsening acute lacunar infarction. Forty-nine consecutive patients with an infarction (as defined by clinical MRI criteria within 48 h after onset) were Clinical, biochemical, rheological, other parameters compared progressive nonprogressive groups....
We investigated the neuroprotective effect and mechanisms of action cilnidipine, a long-acting, second-generation 1,4-dihydropyridine inhibitor L- N-type calcium channels, in PC12 cells that were neuronally differentiated by treatment with nerve growth factor (nPC12 cells). To evaluate cilnidipine on viability, nPC12 treated several concentrations this drug before performing viability assays. Free radical levels intracellular signaling proteins measured fluorescent probe,...
A 64-year-old man presented with sudden onset of right-sided hemiparesis, headache, gait disturbance, and recurrent vomiting. physical examination revealed right Horner syndrome, ataxia the limbs, diminished sensation on left side his body. Diffusion-weighted MRI an acute lateral medullary infarction extending from rostral medulla to upper cervical cord, cerebellar in territory medial branch posterior inferior artery. Magnetic resonance angiography suspicious severe stenosis or near...
We examined the neuroprotective effects of long-acting third-generation dihydropyridine Ca(2+) antagonists, amlodipine besylate (AB) and camsylate (AC), on neuronal cell death induced by oxidative stress. Cell viability levels free radicals intracellular signaling proteins were measured after treating primary cultures cortical neurons with AB, AC, and/or hydrogen peroxide (H(2) O(2) ) under various conditions. was not affected concentrations AB or AC up to 5 μM but decreased at higher...