A5032277807- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Aortic aneurysm repair treatments
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Dysphagia Assessment and Management
- Trauma Management and Diagnosis
- Aortic Thrombus and Embolism
- Spatial Neglect and Hemispheric Dysfunction
- Traditional Chinese Medicine Studies
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- MRI in cancer diagnosis
- Neurosurgical Procedures and Complications
- Cardiovascular and Diving-Related Complications
- Healthcare and Venom Research
- Abdominal vascular conditions and treatments
Yiwu Science and Technology Research Institute
2025
Yonsei University
2009-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
University of Calgary
2017-2023
The University of Melbourne
2017-2018
The Royal Melbourne Hospital
2018
Foothills Medical Centre
2018
CHA University
2013-2016
CHA Bundang Medical Center
2013-2016
Severance Hospital
2013-2016
<h3>Objective:</h3> To investigate whether angiographically defined occlusion type could predict of the etiology acute intracranial large artery and stentriever response. <h3>Methods:</h3> We reviewed consecutive patients with who underwent endovascular treatment examined their workups for embolic sources. Patient demographics, laboratory findings, hyperdense sign, angiographic (truncal-type or branching-site occlusion) were compared between sources (+) (−) groups. These variables also...
Background and Purpose— We investigated the relationship between degree of thrombus resolution time from stroke onset or formation to intravenous tissue-type plasminogen activator (tPA) treatment. Methods— In patients with stroke, we measured volume on thin-section noncontrast brain computed tomographic scans taken at baseline 1 hour after tPA administration. determined association symptom treatment resolution. a C57/BL6 mouse model FeCl 3 -induced carotid artery thrombosis, effect...
The recently developed total cerebral small-vessel disease (CSVD) score might appropriately reflect the burden or severity of CSVD. We investigated whether CSVD is associated with long-term outcomes during follow-up in patients acute ischemic stroke. In total, 1,096 consecutive stroke who underwent brain magnetic resonance imaging were enrolled. calculated for each patient after determining microbleeds (CMBs), high-grade white-matter hyperintensities (HWHs), perivascular spaces (HPVSs), and...
<h3>Objectives:</h3> We investigated the association of cerebral microbleeds (CMBs) with long-term mortality in patients nonvalvular atrial fibrillation (NVAF) according to burden and distribution CMBs. <h3>Methods:</h3> This was a retrospective, hospital-based, observational study. In total, 504 consecutive ischemic stroke NVAF who underwent brain T2-weighted, gradient-recalled echo MRI were included. Data for date causes death based on certificates from Korean National Statistical Office....
Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its value in patients with acute stroke is unknown. We evaluated the prognostic 1765 who had admitted ischemic completed measurement during admission. Primary outcomes were all-cause vascular (death because heart diseases, cerebrovascular or diseases arteries,...
Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease an increased risk of cardiovascular events. However, the association ALP/phosphate cerebral atherosclerosis prognosis in patients acute stroke is not well known.In 1034 first-ever infarction, ALP were compared (1) (2) poor long-term functional outcomes as defined by modified Rankin Scale>2 at 3 months after onset.ALP atherosclerosis. higher a outcome (adjusted odds ratio per 1 SD, 1.25;...
The objective of this study was to assess the prognostic value interarm difference blood pressure (IAD) measured in acute ischemic stroke and investigate its association with systemic atherosclerosis.This a hospital-based retrospective observational study. Survival data systolic/diastolic IAD were collected patients stroke. Systemic atherosclerosis determined based on coronary CT angiography, transesophageal echocardiography, ankle-brachial index examination, cerebral angiography covering...
Cerebral small vessel disease (SVDs) are related with large artery atherosclerosis. However, the association between aortic atheroma (AA) and cerebral has rarely been reported. This study evaluated relationship presence burden of AAs those SVDs in patients acute ischemic stroke.We included 737 consecutive who underwent transesophageal echocardiography (TEE) brain magnetic resonance imaging (MRI) for evaluation stroke. AA subtypes were classified as complex plaque (CAP) simple (SAP). Presence...
Background and Purpose- We investigated whether measuring the volume density of a thrombus could predict nonrecanalization after intravenous thrombolysis. Methods- This study included retrospective cohort to develop computed tomography marker for predicting thrombolysis prospective multicenter validation this marker. The were measured semiautomatically using 3-dimensional software on baseline thin-section noncontrast (1 or 1.25 mm). Recanalization was assessed angiography magnetic resonance...
The benefit of statins in acute stroke remains uncertain. Statins may prevent recurrence during the stage via pleiotropic effects. However, increase risk intracerebral hemorrhage. We investigated effect and safety rosuvastatin patients.This randomized, double-blind, multi-center trial compared 20 mg placebo statin-naïve patients who underwent diffusion-weighted imaging (DWI) within 48 hours after symptom onset. primary outcome was occurrence new ischemic lesions on DWI at 5 or 14 days.This...
Background and Purpose Factors associated with early arrival may vary according to the characteristics of hospital. We investigated factors hospital in two different stroke centers located Korea Japan. Methods Consecutive patients ischemic arrived within 48 hours onset between January 2011 December 2012 were identified clinical time variables retrieved from prospective registries Severance Hospital Yonsei University Health System (YUHS; Seoul, Korea) National Cerebral Cardiovascular Center...
Background and Purpose— We investigated whether the brachial-ankle pulse wave velocity (baPWV) has prognostic value for predicting functional outcome after acute cerebral infarction differs between stroke subtypes. Methods— included 1091 consecutive patients with first-ever who underwent baPWV measurements. Stroke subtypes were classified using Trial of Org 10172 in Acute Treatment classification. Poor outcomes defined as modified Rankin Scale score >2 at 3 months onset. Results— noted...
This retrospective study investigated whether the volume or density of thrombus is predictive recanalization in stent retriever (SR) treatment. Consecutive patients treated with SR thrombectomy as first endovascular modality were enrolled. The and measured on thin-section noncontrast computed tomography using 3-dimensional software. grouped by status number passes. Among 165 patients, was achieved pass 68 (50.0%), 2-3 passes 43 (31.6%), ≥4 25 (18.4%) patients. smaller (107.5 mm3) than...
Background & Aims Liver fibrosis is a multifactorial disease that can affect the development of cerebral small vessel diseases (SVDs) including microbleeds (CMBs), leukoaraiosis, and silent infarctions. Transient elastography accurately assess degree liver by measuring stiffness (LS). In present study, we investigated association between SVDs LS values. Methods We recruited 300 participants (mean age 56 years, 170 men) who underwent comprehensive medical health check-up January 2011 December...
Spontaneous echo contrast (SEC) is frequently detected in patients with atrial fibrillation (AF). Coexisting SEC AF may be associated heightened thrombogenicity, which affects stroke outcomes.Consecutive nonvalvular who underwent transesophageal echocardiography were included this study. We compared initial severity and functional outcome at 3 months between the those without SEC.Of 440 during a 7-year period, 193 (43.9%) had SEC. Stroke was more severe than (National Institute of Health...
Background and Purpose Widespread use of thrombolytic treatments, along with improved chances survival after an initial ischemic stroke, increases the possibility repeated thrombolysis. There are few reports, however, regarding thrombolysis in patients who have suffered acute stroke. We explored number outcome therapy era multimodal treatments. Methods investigated stroke had received treatments for a period 10 years. Number was determined each patient. Recanalization defined as Thrombolysis...
Background and Purpose— Identifying occult coronary artery stenosis may improve secondary prevention of stroke patients. The aim this study was to derive validate a simple score predict severe in Methods— We derived from French hospital–based cohort consecutive patients (n=300) who had an ischemic or transient attack no previous history heart disease (Predicting Asymptomatic Coronary Artery Disease Patients With Ischemic Stroke Transient Attack [PRECORIS] score) validated the similar Korean...
In the SPOTLIGHT trial (Spot Sign Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy), patients with a computed tomography (CT) angiography spot-sign positive acute intracerebral hemorrhage were randomized rFVIIa (recombinant activated factor VIIa; 80 μg/kg) or placebo within 6 hours onset, aiming limit hematoma expansion. Administration did not significantly reduce this prespecified analysis, we aimed investigate impact delays from baseline imaging study drug administration...
Summary Patent foramen ovale (PFO) is a potential cause of cryptogenic stroke, given the possibility paradoxical embolism from venous to systemic circulation. D-dimer level used screen thrombosis. We investigated risk and mortality according presence PFO levels in stroke patients. A total 570 first-ever patients who underwent transesophageal echocardiography were included this study. was assessed using latex agglutination assay during admission. The association long-term outcomes with...
Purpose: Although early neurological deterioration (END) during the acute stroke period is known to be associated with poor functional outcomes, there little data regarding impact of END on long-term outcomes according characteristics END.The aim this study was investigate whether are differences in mortality among ischemic or transient attack patients.Materials and Methods: defined as any increase (≥1) National Institute Health Stroke Scale score within 7 days after admission.We assessed...