A5038329627- Botulinum Toxin and Related Neurological Disorders
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Neurological Disorders and Treatments
- Acupuncture Treatment Research Studies
- Vestibular and auditory disorders
- Ginkgo biloba and Cashew Applications
- Plant-based Medicinal Research
- Fatty Acid Research and Health
- Stress Responses and Cortisol
- Gastrointestinal motility and disorders
- Erythrocyte Function and Pathophysiology
- Tryptophan and brain disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Traditional Chinese Medicine Studies
- Acute Ischemic Stroke Management
- Pelvic floor disorders treatments
- Pharmacological Effects of Natural Compounds
- Cerebrovascular and Carotid Artery Diseases
- Cholesterol and Lipid Metabolism
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Cholinesterase and Neurodegenerative Diseases
Integrated Chinese Medicine (China)
2021-2025
Hunan Academy of Traditional Chinese Medicine
2021-2025
GTx (United States)
2021
Hunan University of Traditional Chinese Medicine
2021
Hunan University
2021
Objective K + –Cl − cotransporter-2 (KCC2), which primarily extrudes chloride in mature neurons, triggers hemiplegia limb spasticity after ischemic stroke by affecting neuronal excitability. Our previous study revealed that the Chinese herb Baishaoluoshi Decoction decreases poststroke (PSS) patients. This aimed at elucidating on effects of BDNF/TrKB-KCC2 pathway PSS rat models. Methods Middle cerebral artery occlusion (MCAO) was adopted for establishment Muscle tension evaluated Modified...
Post-stroke spasticity (PSS) is among the prevalent complications of stroke, greatly affecting motor function recovery and reducing patients' quality life without timely treatment. Sangdantongluo granule, a modern traditional Chinese patent medicine, has significant clinical efficacy in treating PSS. However, mechanism granule PSS still unknown. We designed this study to explore through multimodal functional magnetic resonance imaging (fMRI) combined with transcranial stimulation (TMS). In...
Abstract Ischemic stroke results in inhibition of axonal regeneration but the roles fibrinogen (Fg) neuronal signaling and energy crises experimental are under-investigated. We explored mechanism Fg modulation crisis after cerebral ischemia using a permanent middle artery occlusion (MCAO) rat model primary cortical neurons under low glucose-low oxygen. Behavioral tests assessed neurological deficits; immunofluorescence, immunohistochemistry, Western-blot analyzed protein levels. Fluo-3/AM...
To explore the molecular mechanism of Sijunzi Decoction (SJZD) in treatment Parkinson's disease (PD) through application network pharmacology, docking, and dynamics simulations, complemented by experimental verification.
<sec> <title>BACKGROUND</title> Post-stroke spasticity (PSS) is a frequent sequela in patients who have suffered stroke. This form of paralysis more prevalent compared to other post-stroke sequelae and among the most challenging complex symptoms manage. Surface electromyography (sEMG) can reflect physiological information muscles real time highly beneficial diagnosing neuromuscular diseases clinical medicine. study aimed investigate timing limb spasms using nested case-control combined with...
Abstract Background Vascular cognitive impairment (VCI) is one of the most common diseases among elderly. However, few effective drugs have been approved for VCI. Traditional Chinese medicine (TCM) has used in dementia thousands years. Currently, there limited high-quality evidence efficacy TCM, and specific characteristics its effects appropriate patient populations TCM therapies remain unclear. Herein, we aim to explore effectiveness safety by conducting a longitudinal, patient-centered...
Stroke is the first leading cause of mortality and disability worldwide, post-stroke spasticity (PSS) common complication stroke. Sangdantongluo Granule (Z20210481000), a modern patent Chinese medicine, widely used in clinical practice to treat PSS. Whereas, there limited evidence effectiveness for This study will evaluate efficacy safety granule treatment Analysis multicenter, randomized, double-blind placebo-controlled recruit 132 participants China who develops PSS 15 days–90 days after...
Abstract Background Zuogui Jiangtang Jieyu formulation (ZGJTJY) is a Chinese polyherbal prescription for diabetes-related depression (DD). The mechanism underlying hippocampal M1/M2 polarization in DD and the ZGJTJY treatment effects remain unclear. This study aimed to investigate microglial hippocampus of rats HAPI (highly aggressively proliferating immortalized) cells simulating state, as well examine intervention effects, both vivo vitro. Methods We subjected Sprague Dawley high-fat diet,...
Abstract BackgroundStroke is the first leading cause of mortality and disability worldwide, post-stroke spasticity (PSS) common complication stroke. Sangdantongluo Granule, a modern patent Traditional Chinese medicine (TCM), widely used in clinical practice to treat PSS. Whereas, there limited evidence effectiveness for Granule This study will evaluate efficacy safety granule treatment MethodsThis multicenter, randomized, double-blind placebo-controlled recruit 132 participants China who...