Hyung Seok Guk

ORCID: 0000-0003-2839-012X
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About
Contact & Profiles
Research Areas
  • Cerebrovascular and Carotid Artery Diseases
  • Acute Ischemic Stroke Management
  • Stroke Rehabilitation and Recovery
  • Neurological Disorders and Treatments
  • Venous Thromboembolism Diagnosis and Management
  • Advanced MRI Techniques and Applications
  • Neurological Disease Mechanisms and Treatments
  • Cerebral Venous Sinus Thrombosis
  • Vitamin K Research Studies
  • Cardiovascular Effects of Exercise
  • Cerebrospinal fluid and hydrocephalus
  • Hereditary Neurological Disorders
  • Neurological diseases and metabolism
  • Cardiac tumors and thrombi
  • Fetal and Pediatric Neurological Disorders
  • Blood Pressure and Hypertension Studies
  • Lipoproteins and Cardiovascular Health
  • Eicosanoids and Hypertension Pharmacology
  • Advanced Neuroimaging Techniques and Applications
  • Heart Rate Variability and Autonomic Control
  • Cardiac Health and Mental Health
  • Cardiovascular Health and Disease Prevention
  • Cardiovascular and Diving-Related Complications
  • Spinal Dysraphism and Malformations
  • Atrial Fibrillation Management and Outcomes

Seoul National University Bundang Hospital
2024-2025

Incheon Medical Center
2024

The English Linguistics Society of Korea
2021-2023

Seoul Metropolitan Government
2019

Seoul National University
2019

Boramae Medical Center
2019

Seoul National University Hospital
2019

Background: Previous risk assessment tools for patients with atrial fibrillation (AF) have not primarily focused on those acute ischemic stroke (AIS). Prediction models that rely solely clinical parameters shown limited predictive ability, underscoring the need incorporate neuroimaging to improve prediction of recurrence in AIS AF. Method: The East-Asian Ischemic Stroke Patients Atrial Fibrillation (EAST-AF) study was a nationwide, multicenter prospective registry enrolled AF from 15...

10.1161/str.56.suppl_1.wp321 article EN Stroke 2025-01-30

Introduction: The human microbiome has been studied in various diseases, including inflammatory bowel disease, diabetes, obesity, and cardiovascular diseases. However, its role acute ischemic stroke (AIS) remains underexplored. This study aims to investigate the profiles stool saliva samples from AIS patients compared control groups identify distinct microbial patterns associated with stroke. Methods: We enrolled 54 patients, collecting within one week of admission. Saliva was either...

10.1161/str.56.suppl_1.wp374 article EN Stroke 2025-01-30

Introduction: Current guidelines solely recommend optimal medical therapy including antiplatelet, lipid lowering, and antihypertensive treatment due to the unclear efficacy of stenting endarterectomy for symptomatic vertebral artery (VA) stenosis. However, incidence recurrent ischemic stroke(RIS) in VA steno-occlusion under real-world settings is not well established. This study aims assess RIS identify high-risk populations who might benefit from additional interventions among patients with...

10.1161/str.56.suppl_1.wp277 article EN Stroke 2025-01-30

Background Elevated heart rate in patients with acute ischemic stroke is associated increased risk of mortality. Beta‐blocker therapy well known to reduce rate. Methods and Results This study was a post hoc analysis maximum rates ≥100 bpm. use, assessed on the eighth day after index stroke, categorized as persistent or nonpersistent based usage up 39 months. The primary outcome composite recurrence, myocardial infarction, mortality within first year. Long‐term mortality, secondary outcome,...

10.1161/jaha.124.039678 article EN cc-by-nc-nd Journal of the American Heart Association 2025-03-13

<b><i>Background:</i></b> Although patent foramen ovale (PFO) is considered to be the main cause of cryptogenic stroke, it difficult define “true” PFO-related stroke. <b><i>Objective:</i></b> In this study, we evaluated comprehensive diffusion-weighted imaging (DWI) findings in patients with stroke according right-to-left shunt (RLS) amounts on transcranial Doppler (TCD) sonography. <b><i>Methods:</i></b> We assessed...

10.1159/000502882 article EN Cerebrovascular Diseases 2019-01-01

Lenticulostriate infarction requires further research of arterial hemodynamic factors, as the disease is diagnosed in absence major stenosis or cardioembolism.In this multicenter retrospective cohort study, we included patients who were hospitalized for lenticulostriate from January 2015 to March 2021 at three stroke centers South Korea. We obtained information on cerebral arteries using signal intensity gradient (SIG), an in-vivo approximated wall shear stress (WSS) derived Time-of-Flight...

10.3389/fneur.2023.1220840 article EN cc-by Frontiers in Neurology 2023-09-20

Renal dysfunction is known to affect vasculature and lead systemic arterial stiffness. It also independently increases the risk of cerebral small vessel disease (cSVD) stroke. We aimed examine effect renal on hemodynamics burden cSVD.Of 412 patients admitted Seoul National University Hospital, between May 2015 2019, with lacunar infarction no major intracranial stenosis observed magnetic resonance angiography, we included 283 who had undergone a transcranial Doppler (TCD) ultrasound after 72...

10.1159/000517137 article EN cc-by-nc Cerebrovascular Diseases 2021-01-01

Background: The efficacy of beta-blockers in acute ischemic stroke remains ambiguous. Research targeting high-risk patients, especially those with elevated heart rates, is crucial. Methods: A comprehensive multicenter registry patients was integrated the National Health Insurance Service database. We focused on exhibiting a rate ≥100 bpm between days 3-7 post-symptom onset. These were categorized based whether they received beta-blocker prescription by day 8. To account for potential...

10.1161/str.55.suppl_1.tmp107 article EN Stroke 2024-02-01

Background: Elevated heart rates significantly correlate with increased mortality and major vascular events in patients acute ischemic stroke (AIS). This study explores the therapeutic benefits of beta-blockers for this high-risk group. Methods: was as retrospective cohort 5,049 AIS admitted to 14 hospitals from January 2011 October 2018, who had a maximum rate ≥100 bpm 4th 7th day post-stroke. Beta-blocker usage assessed prescription records beginning 8th Patients were categorized...

10.2139/ssrn.4845124 preprint EN 2024-01-01

Understanding the effectiveness of statin treatment is essential for developing tailored stroke prevention strategies. We aimed to evaluate efficacy in preventing recurrent among patients with various ischemic subtypes. Using data from Clinical Research Collaboration Stroke-Korea-National Institute Health (CRCS-K-NIH) registry, we included acute admitted between January 2011 and July 2020. To differential effects based on subtype, analyzed large artery atherosclerosis (LAA), cardio-embolism...

10.22730/jmls.2024.21.2.40 article EN cc-by-nc Journal of Medicine and Life Science 2024-05-31

Background: This study investigated the impact of premorbid functional dependency on post-stroke mortality in patients with anterior circulation stroke (ACS) and posterior (PCS).Methods: enrolled 9,698 who experienced ischemic between January 2011 December 2022. The were classified into ACS PCS groups. Premorbid was defined as modified Rankin Scale ≥3. risks at 3 months 1-year assessed. A subgroup analysis further performed to evaluate risk underwent intravenous thrombolysis endovascular...

10.18700/jnc.240013 article EN cc-by-nc Journal of Neurocritical Care 2024-06-11

Introduction: There is lack of knowledge on whether symptomatic steno-occlusion (SYSO), common in acute ischemic stroke (AIS) patients with atrial fibrillation (AF), could increase the long-term risk recurrence these patients. Methods: From a prospective cohort AIS and AF enrolled 14 centers between Oct 2017 Dec 2018, we identified who underwent MR angiography during hospitalization completed 3-year follow-up including death follow-up. SYSO was defined as (1) ≥ 50% stenosis or occlusion...

10.1161/str.54.suppl_1.wmp97 article EN Stroke 2023-02-01
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