A5082219632- Oral microbiology and periodontitis research
- Bone health and treatments
- Bone and Joint Diseases
- Dental Health and Care Utilization
- Salivary Gland Disorders and Functions
- Dental Implant Techniques and Outcomes
- Gut microbiota and health
- Bone Tissue Engineering Materials
- Dental Research and COVID-19
- Osteomyelitis and Bone Disorders Research
- HIV/AIDS oral health manifestations
- Periodontal Regeneration and Treatments
- Dental Erosion and Treatment
- Dental Radiography and Imaging
- Oral and gingival health research
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Natural Antidiabetic Agents Studies
- Advanced Glycation End Products research
- Stroke Rehabilitation and Recovery
- Cancer Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Bone Tumor Diagnosis and Treatments
- Diabetes and associated disorders
- Cardiovascular Function and Risk Factors
Seoul National University Bundang Hospital
2018-2025
British Society of Periodontology
2021
Insufficient bone volume is one of the major challenges encountered by dentists after dental implant placement. This study aimed to evaluate efficacy a customized three-dimensional polycaprolactone (3D PCL) scaffold fabricated with 3D bio-printing system facilitate rapid alveolar regeneration. Saddle-type defects were surgically created on healed site extracting premolars from mandibles four beagle dogs. The radiologically examined using computed tomography for designing PCL block fit defect...
Abstract The exploration of oral microbiome has been increasing due to its relatedness with various systemic diseases, but standardization saliva sampling for analysis not established, contributing the lack data comparability. Here, we evaluated factors that influence data. Saliva samples were collected by two collection methods (passive drooling and mouthwash) using three saliva-preservation (OMNIgene, DNA/RNA shield, simple collection). A total 18 sequenced both Illumina short-read...
Introduction: The human microbiome has been studied in various diseases, including inflammatory bowel disease, diabetes, obesity, and cardiovascular diseases. However, its role acute ischemic stroke (AIS) remains underexplored. This study aims to investigate the profiles stool saliva samples from AIS patients compared control groups identify distinct microbial patterns associated with stroke. Methods: We enrolled 54 patients, collecting within one week of admission. Saliva was either...
This study aimed to compare oral microbiome profiles between obese and lean individuals without clinical periodontitis, assess changes in the of subjects following bariatric surgery. Individuals with a body mass index (BMI) > 30 were enrolled group, whereas those BMI < 23 served as controls. The surgery which consented surgery, was followed up at 1, 3, 6 months examinations. Oral examinations conducted periodontal disease classified based on probing results. Saliva, buccal subgingival...
Recombinant human bone morphogenetic protein 2 (rhBMP-2) has been widely used in tissue engineering to enhance regeneration because of its osteogenic inductivity. However, clinical outcomes can vary depending on the scaffold materials deliver rhBMP-2. In this study, 3D-printed scaffolds with a ratio 1:1 polycaprolactone and beta-tricalcium phosphate (PCL/T50) were applied as carriers for rhBMP-2 mandibular defect models dog models. Before vivo application, vitro experiments conducted....
We investigated whether periodontal diseases contribute to the development of medication-related osteonecrosis jaw (MRONJ) in addition tooth extraction, which is a major risk factor for MRONJ occurrence.This retrospective, nationwide cohort study was performed using South Korea's National Health Insurance Service database on women aged > 50 years who took bisphosphonates at least 1 year between 2010 and 2015. MRONJ, disease, extraction were defined claims data.Among 27,168 patients analyzed,...
Background: Although tooth loss is known to increase the risk of cognitive impairment and dementia, few studies have investigated association between functional teeth including rehabilitated lost function Objective: We associations numbers occlusal units with in late life. Methods: The current study was conducted as a part Korean Longitudinal Study on Cognitive Aging Dementia (KLOSCAD), community-based elderly cohort study. analyzed 411 participants who agreed additional dental exam....
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well degree injury. Even if there no direct lung damage, severe can enhance sympathetic tones on blood vessels and vascular resistance, resulting in neurogenic pulmonary edema. Conversely, damage worsen by dysregulating immunity. These findings suggest the importance brain-lung axis interactions TBI. However, little research has been conducted topic. An advanced disease...
Background A causal relationship of bisphosphonate (BP) exposure with osteonecrosis the jaw (ONJ) has been reported; however, a definite dose-dependent risk remains to be elucidated beyond current vague recommendations 4-year oral BP for ONJ increase. Objective To identify effect cumulative dose on development in women osteoporosis. Methods retrospective cohort study was designed using National Health Insurance Service—National Screening database Korea. Females over age 50 were diagnosed...
Individuals with autism spectrum disorders (ASD) have difficulty accessing dental care.We aim to verify whether individuals ASD are properly managed by checking the frequency of visits, cost and severity treatment compared those without ASD.This cross-sectional study used Korean Health Insurance Database analyze frequency, in 209,780 people under age 19 or 2020.The average visits for was 2.98 times, which significantly higher (p < 0.001) than 2.89 times ASD.However, USD 132.63, 116.57for...
Objective Next generation sequencing is commonly used to characterize the microbiome structure. MiSeq most analyze due its relatively long read length. Illumina also introduced 250 × 2 chip for NovaSeq. The purpose of this study was compare performance and NovaSeq in context oral study.
The oral microbiome is closely associated with systemic diseases, indicating the presence of bacteremia and inflammatory mediators in circulation. Our research aims to investigate relationship between other microbial habitats. We analyzed 180 specimens from 36 patients, including saliva, buccal swab, plaque, stool, blood samples a healthy group (Non_PD, n = 18) periodontitis (PD, 18). final analysis included 147 specimens, varying sample sizes for each group. Metagenomic was performed using...
Oral health may be associated with cognitive disorders such as mild impairment or dementia.This study elucidates the effects of oral conditions on progression disorders.Data were collected from 153 participants Korean Longitudinal Study Cognitive Aging and Dementia cohort who completed longitudinal dental examinations function assessments using three-wave biannual survey. We analysed relationship between factors conversion function.The ratio maxillary removable partial denture use (p = .03)...
Hyaluronoglucosaminidase (hyaluronidase) increases the local intercellular permeability of peripheral lymphatic channel and capillaries, which may help reduce edema. In present study, effects hyaluronidase on postoperative edema pain reduction were evaluated.The study included 38 patients who underwent guided bone regeneration (GBR) surgery before implantation. Patients randomly assigned to either control group (n=20) or test (n=18). Hyaluronidase was injected into GBR site subjects in...
This longitudinal cohort study aimed to evaluate the relationship between osteonecrosis of jaw and pulp periapical disease in patients who were administered bisphosphonates.
To evaluate the effect of dental screening on risk cardiovascular disease (CVD) using data from a nationwide population-based cohort.This retrospective cohort study extracted 478,245 individuals aged 40-79 years who participated in health programme during 2002-2003 National Health Insurance Service-National Screening Cohort. Based experience, participants were classified into non-screening, general only, and groups. Using Cox proportional hazard models, ratios (HRs) determined for major...
Objectives: Periodontitis is the most common chronic disease that causes tooth loss and related to systemic diseases such as cardiovascular diabetes.An objective indicator of current activity periodontitis necessary.Soluble forms receptor for advanced glycation end products (sRAGE) are markers reflect status inflammatory diseases.In this study, relationship between sRAGE was analyzed determine whether it can be used diagnose state periodontitis.Patients Methods: Eighty-four patients without...
Abstract Background: Osteonecrosis of the jaw (ONJ) is one complication bisphosphonate (BP). Despite being a major risk factor for ONJ, tooth extraction cannot explain all cases ONJ. However, disease that induce inflammation in jawbone, such as pulp and periapical underestimated, studies suggesting relationship are arising. This necessitates determination between ONJ inflammatory disease, which would contribute to understanding treatment ONJ.Methods: We analyzed caries women aged over 50...