A5060485216- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Diverse Approaches in Healthcare and Education Studies
- Cytomegalovirus and herpesvirus research
- Bacterial Infections and Vaccines
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Education and Learning Interventions
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Korean Urban and Social Studies
- MicroRNA in disease regulation
- Educational Systems and Policies
- Psychosocial Factors Impacting Youth
- EEG and Brain-Computer Interfaces
- Plant tissue culture and regeneration
- Drug Transport and Resistance Mechanisms
- Mosquito-borne diseases and control
- Genetic Neurodegenerative Diseases
- Infectious Encephalopathies and Encephalitis
Seoul National University Hospital
2016-2025
Seoul National University
2011-2024
New Generation University College
2022-2024
Dong-A University Hospital
2024
Yeungnam University
2013-2023
National University College
2017-2022
Eulji University
2021
Namseoul University
2020
Neurology, Inc
2020
John Wiley & Sons (United States)
2019
There is no scale for rating the severity of autoimmune encephalitis (AE). In this study, we aimed to develop a novel in patients with diverse AE syndromes and verify reliability validity developed scale.The key items were generated by panel experts selected according content ratios. The was initially applied 50 (development cohort) evaluate its acceptability, reproducibility, internal consistency, construct validity. Then, another independent cohort (validation cohort, n = 38).A new...
Although surgical resection has been an important alternative treatment for patients with intractable epilepsy related to focal cortical dysplasia (FCD), the prognostic relevance of degree pathologic severity is controversial and there only limited information regarding factors involved in refractory FCD.We undertook present study assess whether subtypes FCD affect outcomes drug-resistant epilepsy. We also studied roles clinical various diagnostic modalities treatment.A total 166 consecutive...
Autoimmune encephalitis (AE), represented by anti-leucine-rich glioma-inactivated 1 (anti-LGI1) and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, has increasing clinical significance based on recent discoveries of neuronal autoantibodies. However, its immunopathogenesis is not fully understood. Here, we investigated whether AE associated with the human leukocyte antigen (HLA) subtypes.We compared HLA genotypes 11 anti-LGI1 17 anti-NMDAR patients to control groups, which...
Background and PurposezzAnti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune synaptic it often responds to treatment.We analyzed clinical characteristics anti-NMDAR in Korea.MethodszzSerum and/or cerebrospinal fluid (CSF) adult patients (aged ≥18 years) with undetermined cause were screened for antibodies using a cell-based indirect immunofluorescence assay.The came from 41 university hospitals.ResultszzOf 721 screened, 40 identified details 32...
Abstract Seronegative autoimmune encephalitis is without any identifiable pathogenic antibody. Although it a major subtype of encephalitis, many unmet clinical needs exist in terms characteristics, treatments and prognosis. In this institutional cohort study, patients diagnosed with seronegative available 2-year outcomes were analysed for the disease course, outcome prediction system, effect immunotherapy, necessity further immunotherapy at 6 or 12 months pattern brain atrophy. was...
Objective To evaluate the seizure characteristics and outcome after immunotherapy in adult patients with autoimmune encephalitis (AE) new-onset seizure. Methods Adult (age ≥18 years) AE who underwent were followed-up for at least 6 months included. Seizure frequency was evaluated 2–4 weeks onset of initial categorized as “seizure remission”, “> 50% reduction”, or “no change” based on degree its decrease. Results Forty-one presented analysed. At immunotherapy, 51.2% free, 24.4% had...
Abstract Bacterial meningitis is a neurological emergency with high morbidity and mortality. We herein investigated clinical features, etiology, antimicrobial susceptibility profiles, prognosis of bacterial in adults from single tertiary center. retrospectively reviewed medical records patients laboratory-confirmed 2007 to 2016. Patients recent neurosurgery, head trauma, or indwelling neurosurgical devices were classified as having healthcare-related meningitis. Causative microorganisms...
Patients with postural tachycardia syndrome often appear depressive and report diminished quality of life (QOL). In the current study, we first evaluated if maximal heart rate (HR) increment after standing is associated clinical symptoms in patients excessive orthostatic (OT). Next, investigated correlations among intolerance (OI), depression, health-related QOL these patients. Finally assessed minimal OI suffer from depression or QOL.We performed a comprehensive questionnaire-based...
We investigated the effects of prolonged-release melatonin (PRM) on idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).In this 4-week, randomized, double-blind, placebo-controlled pilot study, 30 participants with polysomnography-confirmed iRBD were assigned to receive PRM 2 mg per day, 6 or placebo. Medication was administered orally min before bedtime. Primary outcomes included scores from Clinical Global Impression-Improvement (CGI-I) and Korean version RBD...
We investigated the domain-specific patterns of association segmental brain volume and white matter signal abnormality (WMSA) with longitudinal changes in cognitive function. Participants from an institutional health check-up program who were aged >50 years, did not have a confirmed central nervous system disorder underwent baseline follow-up evaluations for function MRI interval at least 1 year included. Cognitive was assessed using Consortium to Establish Registry Alzheimer's...
Carotid atherosclerosis is associated with white matter hyperintensity (WMH), potentially resulting in cognitive and gait problems. We assessed the relationship between carotid patterns regional WMH, offering insights into possible mechanisms. reviewed 1,058 consecutive healthy individuals a health check-up program, who chose both optional doppler ultrasonography brain magnetic resonance imaging. Total, periventricular, subcortical WMH volumes were measured using automatic segmentation...