A5091891738- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Tryptophan and brain disorders
- Bacterial Infections and Vaccines
- Heart Rate Variability and Autonomic Control
- Chronic Lymphocytic Leukemia Research
- Neuroscience and Neuropharmacology Research
- Obstructive Sleep Apnea Research
- Total Knee Arthroplasty Outcomes
- Protein Tyrosine Phosphatases
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Myeloid Leukemia Treatments
- Neurological disorders and treatments
- interferon and immune responses
- Pneumonia and Respiratory Infections
- Genetic Neurodegenerative Diseases
- Immunodeficiency and Autoimmune Disorders
- Complement system in diseases
- EEG and Brain-Computer Interfaces
- Antibiotic Resistance in Bacteria
- Mitochondrial Function and Pathology
- Mosquito-borne diseases and control
Seoul National University Hospital
2016-2025
Ajou University
2025
Ajou University Hospital
2025
Seoul National University
2015-2023
Seoul National University Bundang Hospital
2021-2022
National University College
2017
Soonchunhyang University Hospital
2017
Kyung Hee University Hospital at Gangdong
2016-2017
National University
2016
Soonchunhyang University
2016
<h3>Objective:</h3> To determine efficacy and safety of rituximab treatment as a second-line immunotherapy for autoimmune limbic encephalitis (ALE) to factors associated with functional improvement favorable outcome following treatment. <h3>Methods:</h3> We recruited 80 patients ALE who were treated from the Korea Autoimmune Synaptic Paraneoplastic Encephalitis Registry reviewed 81 without control. grouped according detection or type antibodies; in addition, we evaluated clinical,...
Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present novel system neurological emergencies, such as status epilepticus, epileptic condition that requires immediate treatment, soft implantable drug delivery (SID). The SID is integrated wirelessly with wearable monitoring...
Autoimmune encephalitis (AE), represented by anti-leucine-rich glioma-inactivated 1 (anti-LGI1) and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, has increasing clinical significance based on recent discoveries of neuronal autoantibodies. However, its immunopathogenesis is not fully understood. Here, we investigated whether AE associated with the human leukocyte antigen (HLA) subtypes.We compared HLA genotypes 11 anti-LGI1 17 anti-NMDAR patients to control groups, which...
Abstract Bacterial meningitis is a neurological emergency with high morbidity and mortality. We herein investigated clinical features, etiology, antimicrobial susceptibility profiles, prognosis of bacterial in adults from single tertiary center. retrospectively reviewed medical records patients laboratory-confirmed 2007 to 2016. Patients recent neurosurgery, head trauma, or indwelling neurosurgical devices were classified as having healthcare-related meningitis. Causative microorganisms...
Patients with postural tachycardia syndrome often appear depressive and report diminished quality of life (QOL). In the current study, we first evaluated if maximal heart rate (HR) increment after standing is associated clinical symptoms in patients excessive orthostatic (OT). Next, investigated correlations among intolerance (OI), depression, health-related QOL these patients. Finally assessed minimal OI suffer from depression or QOL.We performed a comprehensive questionnaire-based...
Abstract To treat intractable cases of autoimmune encephalitis, the need for novel immunotherapy that penetrates blood‐brain barrier (BBB) is increasing. Tofacitinib a Janus kinase (JAK) inhibitor used to refractory immune‐mediated diseases effectively BBB. Accordingly, tofacitinib could be new option patients with encephalitis. Patients treated were selected from Seoul National University Hospital cohort encephalitis April 2019 until July 2020. We retrospectively analyzed efficacy in who...
Background Cryptogenic new-onset refractory status epilepticus (cNORSE) currently lacks comprehensive knowledge regarding its clinical dynamics, prognostic factors and treatment guidance. Here we present the longitudinal profiles, predictive for outcomes optimal duration of immunotherapy in patients with cNORSE. Methods This retrospective secondary endpoint analysis investigated cNORSE identified from a prospective autoimmune encephalitis cohort at national referral centre Korea. The main...
To evaluate the long-term (for up to 3 months) efficacy and safety of single or combined therapy with midodrine pyridostigmine for neurogenic orthostatic hypotension (OH).This was a randomized, open-label clinical trial. In total, 87 patients symptomatic OH were enrolled randomized receive 1 treatments: only, + pyridostigmine. The followed at months after treatment. primary outcome measures improvement in blood pressure (BP) drop months. Secondary endpoints BP month amelioration...
Severe fever with thrombocytopenia syndrome (SFTS) is a potentially fatal infectious disease if not diagnosed and treated promptly. Typical clinical features include fever, thrombocytopenia, lymphadenopathy. However, we encountered case of SFTS in 60-year-old male who initially did exhibit these hallmark symptoms. The patient presented headache myalgia, but develop until the 4th day hospitalization. Initial neuroimaging cerebrospinal fluid (CSF) analysis revealed no abnormalities. When...
Abstract We aimed to examine the effect of continuous positive airway pressure on sleep quality and alcohol metabolism after consumption. Men (n = 53) aged ≥ 19 years with disorders who regularly consumed an average 1.0 g alcohol/kg bodyweight, were free serious diseases (including liver disorders), underwent polysomnography titration between January 2016 July 2021 included. Participants drank a high dose traditional Korean liquor at rate g/kg bodyweight for 1 h. The main outcome measures...
Abstract Objective Although intravenous immunoglobulin (IVIG) is the first‐line immunotherapy in autoimmune encephalitis, all supporting evidence comes from retrospective case series. Here, we performed a prospective clinical trial of IVIG for functional recovery encephalitis. Methods This single‐arm, open‐label study assessed efficacy and safety 10% treatment newly diagnosed patients with possible Patients received (0.4 g/kg/day) 5 days. Rescue was permitted when patient deteriorated before...
Abstract Aims . To evaluate the efficacy and safety of mega‐dose phenobarbital (MDPB; enteral or parenteral >10 mg/kg/day) for treating super‐refractory status epilepticus (SRSE; continuous recurrent ≥24 hours after onset anaesthetic treatment) in adult patients. Methods Adult patients with SRSE who were treated MDPB our institution from March 2005 to September 2014 reviewed. We collected data on basic demographics, clinical features, functional status, anticonvulsant treatment, possible...
Diabetic foot infections (DFIs) cause substantial morbidity and mortality. The mainstay of the treatment is empiric antibiotics surgical debridement in severe cases. In this study, we performed nanopore 16S rDNA sequencing from specimens DFIs. Fifty-four obtained 45 patients with medically intractable DFI were included. PCR was on each specimen, Nanopore for up to 3 h. reads aligned BLAST database, results compared conventional culture studies. revealed that majority DFIs (44 54, 81.5%)...
Abstract Neuroinflammation contributes to epileptogenesis and ictogenesis. Various signals of neuroinflammation lead neuronal hyper-excitability. Since an interplay between epilepsy, psychiatric comorbidities has been suggested, we explored symptoms in epilepsy patients, the relationship with neuroinflammation. We screened patients who were admitted for video-EEG monitoring July 2019 December 2020. Enrolled asked respond neuropsychiatric questionnaires (Hospital Anxiety Depression Scale...
Abstract Refractory cerebral autoinflammatory–autoimmune diseases are often associated with dysregulated innate immunity and targeted by anakinra, an interleukin‐1 receptor antagonist. We analyzed the therapeutic effect of anakinra in refractory autoinflammatory response (CAIR) at a single institution from January 2017 to May 2021. In total, 12 patients various etiologies were sympathetically treated (100 mg/day subcutaneously). Four showed good responses, among these patients, three had...
Bed-ridden state, dysphagia, altered mental or respiratory muscle weakness are common in neurologic patients and increase the risk of pneumonia. The major causes pneumonia may differ from those general population, resulting a different pathogen distribution. We investigated trends distribution culture-positive hospitalized related antibiotic resistance with hospital-acquired (HAP). A retrospective study was performed at Seoul National University Hospital, South Korea. Patients admitted to...
ObjectivesUrinary tract infection (UTI) is a common medical complication experienced by patients with neurologic diseases. In this study, we established the microbial etiologies of UTI, and resistances to antibiotics in UTI as well determining which appropriate empirical should be used treat neurological patients.Designs methodsWe retrospectively reviewed antimicrobial resistance among experiencing events neurology ward Seoul National University Hospital from 2007 2016.ResultsThe total...
Abstract Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate NfL indicating neuronal damage autosomal-dominant (AD) spinocerebellar ataxia (SCA). We reviewed patients diagnosed with AD SCA outpatient clinic of Seoul National University Hospital’s (SNUH) Department Neurology between May and August 2019. demographic data, clinical characteristics, Scale for Assessment Rating Ataxia (SARA) score, brain magnetic...