A5101860901- Autoimmune Neurological Disorders and Treatments
- Epilepsy research and treatment
- Peripheral Neuropathies and Disorders
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Cytomegalovirus and herpesvirus research
- Sleep and Wakefulness Research
- Herpesvirus Infections and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cellular transport and secretion
- Infectious Encephalopathies and Encephalitis
- Restless Legs Syndrome Research
- Dementia and Cognitive Impairment Research
- Polyomavirus and related diseases
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Bipolar Disorder and Treatment
- Sarcoma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Chronic Lymphocytic Leukemia Research
- Tracheal and airway disorders
- Antibiotics Pharmacokinetics and Efficacy
- Circular RNAs in diseases
- Ion channel regulation and function
Seoul National University Hospital
2015-2024
Epilepsy Foundation
2021
Dankook University Hospital
2020
Seoul National University
1997-2019
Wonkwang University
2019
Biomedical Research Institute
2016
National University
2016
Soonchunhyang University
2016
Armed Forces Capital Hospital
2015-2016
Kyung Hee University Hospital at Gangdong
2016
<h3>Objective:</h3> To determine efficacy and safety of rituximab treatment as a second-line immunotherapy for autoimmune limbic encephalitis (ALE) to factors associated with functional improvement favorable outcome following treatment. <h3>Methods:</h3> We recruited 80 patients ALE who were treated from the Korea Autoimmune Synaptic Paraneoplastic Encephalitis Registry reviewed 81 without control. grouped according detection or type antibodies; in addition, we evaluated clinical,...
There is no scale for rating the severity of autoimmune encephalitis (AE). In this study, we aimed to develop a novel in patients with diverse AE syndromes and verify reliability validity developed scale.The key items were generated by panel experts selected according content ratios. The was initially applied 50 (development cohort) evaluate its acceptability, reproducibility, internal consistency, construct validity. Then, another independent cohort (validation cohort, n = 38).A new...
Autoimmune encephalitis (AE), represented by anti-leucine-rich glioma-inactivated 1 (anti-LGI1) and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, has increasing clinical significance based on recent discoveries of neuronal autoantibodies. However, its immunopathogenesis is not fully understood. Here, we investigated whether AE associated with the human leukocyte antigen (HLA) subtypes.We compared HLA genotypes 11 anti-LGI1 17 anti-NMDAR patients to control groups, which...
Background and PurposezzAnti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune synaptic it often responds to treatment.We analyzed clinical characteristics anti-NMDAR in Korea.MethodszzSerum and/or cerebrospinal fluid (CSF) adult patients (aged ≥18 years) with undetermined cause were screened for antibodies using a cell-based indirect immunofluorescence assay.The came from 41 university hospitals.ResultszzOf 721 screened, 40 identified details 32...
Objective To evaluate the seizure characteristics and outcome after immunotherapy in adult patients with autoimmune encephalitis (AE) new-onset seizure. Methods Adult (age ≥18 years) AE who underwent were followed-up for at least 6 months included. Seizure frequency was evaluated 2–4 weeks onset of initial categorized as “seizure remission”, “> 50% reduction”, or “no change” based on degree its decrease. Results Forty-one presented analysed. At immunotherapy, 51.2% free, 24.4% had...
Abstract Objective To evaluate the therapeutic potential of bortezomib, a proteasome inhibitor that target plasma cells, in order to revive stalled recovery patients with anti‐ N ‐methyl‐ d ‐aspartate ( NMDA ) receptor encephalitis who remain bedridden even after aggressive immunotherapy. Methods We consecutively enrolled remained first‐line immunotherapy (steroids and intravenous immunoglobulin), second‐line (rituximab), tocilizumab treatment, treated them subcutaneous bortezomib. Clinical...
Abstract Objective While immune checkpoint inhibitors are increasingly used for various cancers, unpredictable immune‐related adverse events (irAEs) such as autoimmune encephalitis is life‐threatening. Here, we report an association between human leukocyte antigen (HLA) and atezolizumab‐induced encephalitis. Methods From institutional prospective cohort encephalitis, identified patients with after the use of atezolizumab, a PD‐L1 (programmed death‐ligand 1) inhibitor, from August 2016 to...
Gliomatosis cerebri: comparison of MR and CT features.Y M Shin, K H Chang, Han, N Myung, J G Chi, S Cha C HanAudio Available | Share
Background and Purpose— The high prevalence of intracranial aneurysms (IAs) in patients with a bicuspid aortic valve or coarctation the aorta suggests link between IA pathology. However, studies reporting this do not sufficiently address heterogeneity IAs arising from different anatomic locations. This study aimed to explore whether location-specific relationship exists 2 kinds aneurysms. Methods— Retrospective institutional analysis aged ≥18 years both an aneurysm (AA) was performed 2005...
Background Recent studies showed the possible association between inflammation-induced blood-brain barrier (BBB) structural changes followed by greater permeability of BBB and chronic pain. Thus, measurement breakdown would be a valuable aid in diagnosis migraine. Dynamic contrast material–enhanced (DCE) MRI can determine perfusion properties related to BBB. Purpose To evaluate relationship migraine-associated brain regions using DCE MRI. Materials Methods In this prospective study, from...
Abstract Objective Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) helps optimize management for patients with epilepsy. Salivary testing is both noninvasive and easy, has several other advantages. Due to technical advances, salivary TDM become feasible drugs, including AEDs, its value been investigated. Until recently, saliva perampanel (PER) had not reported. The purpose our study was confirm whether a biological substitute plasma in PER TDM. Methods Adult diagnosed...
As circular RNAs (circRNAs) regulates the effect of micro (miRNAs), circRNA-miRNA-mRNA network might be implicated in various disease pathogenesis. Therefore, we evaluated dysregulated circRNAs Tg2576 mouse Alzheimer's (AD) model, their possible regulatory effects on downstream target mRNAs, and pathomechanistic role during progression. The microarray-based circRNA expression analysis at seven- twelve-months ages (7 M 12 M) returned 101 7 (55 up-regulated 46 down-regulated) twelve (five...
Abstract Background Although previous research provides insight into the role of neuroinflammation in idiopathic REM sleep behavior disorder, association this disorder with peripheral blood inflammatory markers remains unclear. Objective To investigate cytokines plasma samples patients rapid eye movement and to explore whether these are associated prodromal symptoms α‐synucleinopathies. Methods We collected from polysomnographically confirmed without parkinsonism or dementia (n = 54) healthy...