A5031970237- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Corneal Surgery and Treatments
- Metabolism and Genetic Disorders
- Glaucoma and retinal disorders
- Infectious Diseases and Tuberculosis
- Bipolar Disorder and Treatment
- Vascular Malformations Diagnosis and Treatment
- Retinal and Macular Surgery
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Restless Legs Syndrome Research
- Bacterial Infections and Vaccines
- Gastrointestinal motility and disorders
- Sinusitis and nasal conditions
- Herpesvirus Infections and Treatments
- Functional Brain Connectivity Studies
- Systemic Sclerosis and Related Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mosquito-borne diseases and control
- Leptospirosis research and findings
- Ocular and Laser Science Research
Seoul National University Hospital
2009-2025
Seoul National University
2023
Neuropharmacokinetics is an emerging field dedicated to understanding the pharmacokinetics of drugs within central nervous system (CNS), with a particular emphasis on overcoming challenges posed by blood-brain barrier. This paper reviews latest advancements in drug delivery strategies, including nanoparticle-based systems, receptor-mediated transcytosis, and efflux transporter inhibition, which have been designed enhance penetration into brain. Additionally, use advanced imaging techniques...
Many pharmacokinetic studies of lacosamide (LCM) have been reported, but no large-scale clinical study has conducted on genetic polymorphisms that affect the metabolism LCM. Therefore, we designed a pharmacogenetic LCM to explore effect serum concentration. We evaluated pharmacodynamic characteristics LCM, including efficacy and toxicity.Adult patients with epilepsy who received at Seoul National University Hospital were enrolled. Blood samples obtained from 115 taking for more than 1 month...
Abstract Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV‐19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic‐clonic seizures, cognitive decline, and gait disturbance that occurred suddenly the second dose vaccine. Clinical presentation magnetic resonance imaging (MRI) cerebrospinal fluid (CSF) test results were compatible limbic encephalitis. Synaptic autoantibody tests confirmed serum CSF GABA B receptor antibodies...
Febrile seizures at a young age can provoke late-onset temporal lobe epilepsy. Since recent evidence has suggested that the gut microbiome affects central nervous system pathology across blood-brain barrier, we hypothesized febrile alter composition of to
Orientia tsutsugamushi is a major cause of vector-borne infection in Asia. Prompt recognition and appropriate treatment are crucial because its potentially fatal complications lack response to beta-lactam antibiotics. The present study retrospectively evaluated the clinical characteristics laboratory findings 16 patients with scrub typhus-related central nervous system (CNS) infections. Single titers ≥ 1:40 total serum antibodies against O. detected by an indirect immunofluorescent assay...
Summary Anti–leucine‐rich glioma‐inactivated protein 1 ( LGI 1) encephalitis is a rare autoimmune condition presenting mainly as altered mental state, cognitive dysfunction, and seizure. Antiepileptic drugs AED s) are usually initiated to control seizures despite their limited efficacy; however, accumulating clinical experience suggests high incidence of adverse reactions s in anti‐ encephalitis. We reviewed the medical records patients who were diagnosed with analyze effects these patients....
Abstract Objective Familial cerebral cavernous malformation (FCCM) is an autosomal dominant disease induced by loss‐of‐function mutations in three CCM genes, KRIT1 , CCM2 and PDCD10 . However, previous studies paid little attention to analyzing the radiologic features age‐related burden according genes. Therefore, we retrospectively reviewed genetic tests of our center's clinical FCCM patients. Method This study investigated patients with multiple lesions or a family history CCMs who...
Abstract Objective Despite the suggested topiramate serum level of 5–20 mg/L, numerous institutions have observed substantial drug response at lower levels. We aim to investigate correlation between levels, responsiveness, and adverse events establish a more accurate tailored therapeutic range. Methods retrospectively analyzed clinical data collected January 2017 2022 Seoul National University Hospital. Drug responses were categorized as “insufficient” or “sufficient” by reduction in seizure...
Objectives: Sleep-related leg cramps (SRLC) are common among older people. Severe clinical symptoms of SRLC usually cause great discomfort to patients. To date, many treatment drugs have been tried; however, there currently no approved for treating this condition. We aimed assess the efficacy a new drug, oxcarbazepine (OXC), in SRLC.Methods: retrospectively analyzed outcomes following OXC administration. A daily dose 150 mg was prescribed control nocturnal cramps. Clinical were measured...