A5011226485- Diabetes Treatment and Management
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Metabolism, Diabetes, and Cancer
- Antibiotics Pharmacokinetics and Efficacy
- Pancreatic function and diabetes
- Statistical Methods in Clinical Trials
- Anesthesia and Sedative Agents
- Health Systems, Economic Evaluations, Quality of Life
- Epilepsy research and treatment
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Gastroesophageal reflux and treatments
- Advanced Combinatorial Mathematics
- Helicobacter pylori-related gastroenterology studies
- Analytical Methods in Pharmaceuticals
- Tuberculosis Research and Epidemiology
- Pharmacology and Obesity Treatment
- Pneumonia and Respiratory Infections
- Pharmaceutical Economics and Policy
- Blood disorders and treatments
- Bacterial Infections and Vaccines
- Anesthesia and Neurotoxicity Research
- Retinal Development and Disorders
Seoul National University Hospital
2016-2025
Jeju National University
2023-2025
Jeju National University Hospital
2024-2025
New Generation University College
2018-2024
Seoul National University
2018-2024
National University College
2018-2024
Weatherford College
2024
Ewha Womans University
2023
Yonsei University
2023
Severance Hospital
2023
Abstract Despite substantial advances in disease genetics, studies to date have largely focused on individuals of European descent. This limits further discoveries novel functional genetic variants other ethnic groups. To alleviate the paucity East Asian population genome resources, we established Korean Variant Archive 2 (KOVA 2), which is composed 1896 whole-genome sequences and 3409 whole-exome from healthy ethnicity. largest database date, surpassing 1909 deposited gnomAD. The KOVA...
Digital therapeutics (DTx) are software-based therapeutic interventions based on clinical evidence. Randomized trials (RCTs) often the source of evidence, similar to conventional drugs or medical devices. However, novel approaches such as use real-world data digital biomarkers also utilized. This article aimed review how DTx products have been clinically evaluated.DTx approved by US Food and Drug Administration 2020 were reviewed with sufficient published information selected. Pivotal...
Hermansky-Pudlak syndrome (HPS) is a rare, often fatal, autosomal recessive disorder in which albinism, bleeding and lysosomal storage are associated with defects of diverse cytoplasmic organelles, including melanosomes, platelet dense granules lysosomes. Similar multi-organellar occur the Chediak-Higashi (CHS), as well large number different mouse mutants. The HPS gene located 10q23, two genetically distinct loci, pale ear (ep) ruby-eye (ru), both mutant phenotypes similar to human HPS, map...
A novel potassium-competitive acid blocker, DWP14012, is in clinical development as a potential alternative to proton pump inhibitors for the treatment of acid-related diseases.To evaluate safety, tolerability, pharmacodynamics and pharmacokinetics DWP14012 humans.A randomised, double-blind, double-dummy, placebo- active-controlled, single- multiple-ascending dose (SAD MAD, respectively) study was conducted healthy male subjects without Helicobacter pylori infection. Subjects randomly...
Zastaprazan (JP-1366) is a novel potassium-competitive acid blocker with favourable preclinical safety and efficacy profile being developed for the treatment of acid-related diseases.To investigate safety, tolerability, pharmacodynamics pharmacokinetics zastaprazan.A randomised, open-label, placebo- active-controlled, single multiple ascending dose clinical trial was conducted in healthy Korean male subjects. Intragatric pH serum gastrin were measured to assess pharmacodynamics, while serial...
Chemotherapy-induced alopecia (CIA) is a side effect of the anticancer drug 5-fluorouracil (5-FU). However, mechanism action in hair follicle cells unclear. This study investigated 5-FU on cycle and growth vitro vivo. Intraperitoneal injection into C57BL/6 mice delayed anagen initiation, resulting small follicles. inhibited angiogenesis by reducing cluster differentiation 31+ cells, vascular endothelial factor, fetal liver kinase-1 expression mouse skin tissue rat vibrissa dermal papilla...
Abstract Background and aim Severe fever with thrombocytopenia syndrome (SFTS) is a fatal tick-borne infectious disease lacking effective treatments or vaccines. Early identification of prognostic factors essential for optimizing clinical management. This study investigated the predictors mortality in SFTS patients. Methods We conducted retrospective multicenter cohort 413 patients hospitalized South Korea from 2013 to 2024. Clinical laboratory data were comprehensively analyzed evaluate...
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a fatal tick-borne infectious disease that lacks effective treatments. Dynamic analysis reflects changes in the SFTS patient’s condition needed. This study aimed to evaluate time-dependent predictive performance of key biomarkers using Cox regression model. A retrospective multicenter cohort was conducted on 440 patients hospitalized South Korea between 2013 and 2024. Time-dependent receiver operating characteristic (ROC)...
Abstract Background Post-transplantation cyclophosphamide (PTCy) has paved the way for increased use of alternative donors, including haploidentical familial with acceptable engraftment and graft-versus-host disease (GVHD) rates. However, pharmacokinetic studies PTCy in pediatric population following myeloablative conditioning regimens are scarce. Methods We conducted a prospective comprehensive analysis pre- post-transplantation levels patients undergoing hematopoietic stem cell...
The intraocular route of drug administration enables the delivery high concentrations therapeutic drugs, while minimizing their systemic absorption. Several drugs are administered into anterior chamber or vitreous, and injection has been effective in curing various diseases. Rabbit eyes have widely used for ophthalmic research, as animal is easy to handle economical compared other mammals, size a rabbit eye similar that human eye. Using 30 G needle, can be injected intracameral intravitreal...
Summary Background Potassium‐competitive acid blockers (P‐CABs) are emerging as novel treatments for acid‐related disorders including gastroesophageal reflux disease. Tegoprazan and revaprazan approved P‐CABs in South Korea, but the pharmacodynamics safety/tolerability of two drugs have never been compared. Aims To evaluate tegoprazan after single multiple oral doses Methods A randomised, open‐label, active‐controlled study was conducted Helicobacter pylori ‐negative healthy Korean male...
We hypothesized that the pharmacodynamic (PD) characteristics of metformin would change with inhibition multidrug and toxin extrusion (MATE) transporter, which mediates renal elimination metformin. Twenty healthy male subjects received two doses (750/500 mg) metformin, without 50 mg pyrimethamine (a potent MATE inhibitor), 1 week washout in between each dose. The PD were assessed using oral glucose tolerance tests (OGTTs) before after Metformin concentrations plasma urine determined liquid...
DWP16001 is a novel sodium-glucose cotransporter-2 inhibitor under development for the treatment of type 2 diabetes mellitus. This study was conducted to evaluate pharmacokinetics, pharmacodynamics and safety after single multiple doses in healthy subjects.A randomized, double-blind, placebo- active-controlled, single- multiple-dose conducted. Twelve subjects each dose group received (0.2, 0.5, 1.0, 2.0 or 5.0 mg) (0.1, 0.3, 1.0 mg once daily 15 consecutive days) DWP16001, dapagliflozin 10...
Effects of CYP2C19 Genetic Polymorphisms on
Decreased oral clopidogrel absorption caused by induction of intestinal permeability glycoprotein (P-gp) expression after aspirin administration was observed in rats. This study evaluated the effect coadministration on pharmacokinetics/pharmacodynamics humans. A single 75-mg dose orally administered before and 2 4 weeks once-daily 100-mg 18 healthy volunteers who were recruited based CYP2C19 PON1 genotypes. Plasma concentrations its active metabolite, H4, relative platelet inhibition (RPI)...
Background The aim of this study was to explore the pharmacokinetic-pharmacodynamic (PK-PD) relationship metformin on glucose levels after administration 250 mg and 1000 in healthy volunteers. Methods A total 20 male volunteers were randomized receive two doses either a low dose (375 followed by mg) or high (1000 at 12-h intervals. pharmacodynamics assessed using oral tolerance tests before administration. PK parameters second evaluated through noncompartmental analyses. Four single...
Abstract Sildenafil is widely used off-label in pediatric patients with pulmonary arterial hypertension (PAH). This study was conducted to characterize the pharmacokinetics (PK) of sildenafil term and preterm neonates PAH, by developing a population PK model, suggest appropriate doses achieve clinically effective concentrations. A modelling analysis performed using its metabolite N-desmethyl (DMS) concentration data from 19 whose gestational ages ranged 24–41 weeks. They received orally at...
Abstract Bersiporocin, a novel first‐in‐class prolyl‐tRNA synthetase (PRS) inhibitor currently under clinical development, was shown to exert an antifibrotic effect through the downregulation of collagen synthesis in various pulmonary fibrosis models. The aim this first‐in‐human, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐dose, dose‐escalation study evaluate safety, tolerability, pharmacokinetic (PK) pharmacodynamic (PD) characteristics bersiporocin healthy adults. A...
Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that may increase susceptibility of individuals AT-DILI and examine interactions lead (INH)-induced hepatotoxicity. We performed a targeted sequencing analysis 380 pharmacogenes in discovery cohort 112 patients (35 77 controls) receiving AT treatment for active tuberculosis....
The intraocular route of drug administration enables the delivery high concentrations therapeutic drugs, while minimizing their systemic absorption.Several drugs are administered into anterior chamber or vitreous, and injection has been effective in curing various diseases.Rabbit eyes have widely used for ophthalmic research, as animal is easy to handle economical compared other mammals, size a rabbit eye similar that human eye.Using 30 G needle, can be injected intracameral intravitreal...
Background: Colistin is increasingly used as the last therapeutic option for treatment of multidrug-resistant, Gram-negative bacterial infections. To ensure safe and efficacious use colistin, drug monitoring (TDM) needed due to its narrow window. This study aimed evaluate pharmacokinetic (PK) characteristics colistin guide TDM in colistin-treated patients Korea. Methods: In a prospective study, we analyzed PK 15 who intravenously received methanesulfonate twice per day. doses were adjusted...
Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted decrease enzymatic activity in an silico analysis. This study evaluated the effect of SNP on pharmacokinetics (PK) oseltamivir humans.A oral dose at 75 mg administered 20 healthy subjects, 8 heterozygous carriers (c.662AG) 12 non-carriers (c.662AA). The...
Many pharmacokinetic studies of lacosamide (LCM) have been reported, but no large-scale clinical study has conducted on genetic polymorphisms that affect the metabolism LCM. Therefore, we designed a pharmacogenetic LCM to explore effect serum concentration. We evaluated pharmacodynamic characteristics LCM, including efficacy and toxicity.Adult patients with epilepsy who received at Seoul National University Hospital were enrolled. Blood samples obtained from 115 taking for more than 1 month...
Therapeutic drug monitoring (TDM) of second-line antituberculosis drugs would allow for optimal individualized dosage adjustments and improve safety therapeutic outcomes. To evaluate the pharmacokinetic (PK) characteristics clinically relevant, multidrug treatment regimens to feasibility TDM, we conducted an open-label, multiple-dosing study with 16 healthy subjects who were divided into two groups. Cycloserine (250 mg), p-aminosalicylic acid (PAS) (5.28 g), prothionamide mg) twice daily...