A5101590445- Epilepsy research and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical studies and practices
- Electrochemical sensors and biosensors
- Ion-surface interactions and analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Lipoproteins and Cardiovascular Health
- Treatment of Major Depression
- Blood Pressure and Hypertension Studies
- Analytical Chemistry and Chromatography
- Anesthesia and Sedative Agents
- Trace Elements in Health
- Inflammatory Bowel Disease
- Tuberculosis Research and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Hormonal Regulation and Hypertension
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
National Institute of Food and Drug Safety Evaluation
2017-2021
Ministry of Food and Drug Safety
2000-2021
Chungnam National University
2020-2021
Cornell University
1992
Unit-resolution mass spectra have been obtained for peptides as large 17 kDa, providing information on impurities and adduct ions, well accurate molecular weight values. Electrospray ionization produces many multiply-charged species of the same mass; isotopic peak resolution provides direct charge state assignment from unit spacing isotopes. This is special value when spectrum also has masses, such precursor ion dissociation or impurities. Mass measuring errors not only are concomitantly...
Effects of CYP2C19 Genetic Polymorphisms on
Aim: To investigate the combined effects of SLCO1B1 and ABCB1 genotypes on pharmacokinetics simvastatin its active metabolite acid, in relation to CYP3A4 inhibition. Methods: We conducted a single-dose pharmacokinetic study 26 healthy volunteers screened for their c.521T>C c.1236C>T–2677G>T–3435C>T genotypes, with without amlodipine pretreatment. The genetic drug-interaction effect parameters were analyzed using linear-mixed model. Results: variant significantly increased exposure acid by...
Background: Carvedilol is commonly used to treat hypertension as a βand α 1 -adrenoreceptor blocker, but it metabolized by CYP2D6, and CYP2D6 * 10 allele dominant in Asian population.The objective of this study was assess the influence polymorphisms on pharmacokinetic (PK) pharmacodynamic (PD) characteristics carvedilol healthy Korean volunteers.Methods: A PK/PD for single multiple dosing were conducted.All volunteers 3 genotypic groups received oral dose 12.5 mg days, then 25 QD 5 another...
Abstract Amitriptyline is a tricyclic antidepressant that metabolized mainly by CYP2C19 and CYP2D6 enzymes. Higher plasma levels of amitriptyline its active metabolite, nortriptyline, are associated with an increased risk adverse events including anticholinergic effects. The aim this study was to evaluate the effects genetic polymorphisms on nortriptyline pharmacokinetics. Twenty‐four Korean healthy adult male volunteers were enrolled in after stratification their genotypes. Serial blood...
ABSTRACT Aim Several studies have reported population pharmacokinetic models for phenobarbital (PB), but the predictive performance of these has not been well documented. This study aims to do external validation in published models. Methods Therapeutic drug monitoring data collected neonates and young infants treated with PB seizure control, was used validation. A literature review conducted through PubMed identify Prediction- simulation-based diagnostics, Bayesian forecasting were...
Inflammatory bowel disease (IBD) subdividing into Crohn's (CD) and ulcerative colitis (UC) is a chronic intestinal inflammatory disorder. Infliximab (IFX) as an anti-TNF-α has been prescribed for treatment of IBD patients. However, some patients show no response or loss to this agent. In study, we investigated identify genetic variants associated with IFX. A total 148 from Yonsei University Health System who received IFX were classified according subtypes except 12 unsuitable study. We also...