A5000618814- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Tryptophan and brain disorders
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Health, Environment, Cognitive Aging
- Stress Responses and Cortisol
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Sleep and related disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Personality Disorders and Psychopathology
- Botulinum Toxin and Related Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Multiple Sclerosis Research Studies
- Psychotherapy Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Metabolomics and Mass Spectrometry Studies
- Sleep and Wakefulness Research
- Fetal and Pediatric Neurological Disorders
- Genetic Neurodegenerative Diseases
Glostrup Hospital
2016-2023
Copenhagen University Hospital
2015-2023
University of Copenhagen
2016-2023
Center for Clinical & Basic Research
2020
Mental Health Services
2019-2020
Gentofte Hospital
2019
Rigshospitalet
2017-2019
University of Washington
2016
Columbia University
2016
Harvard University
2016
Background Many psychological treatments have shown effect on reducing self-harm in adults with borderline personality disorder. There is a need of brief psychotherapeutical treatment alternative for suicide prevention specialized outpatient clinics. Methods/Design The DiaS trial was designed as pragmatic single-center, two-armed, parallel-group observer-blinded, randomized clinical superiority trial. participants had at least two criteria from the disorder diagnosis and recent attempt...
Patients at ultra-high risk (UHR) for psychosis show significant impairments in functioning. It is essential to determine which factors influence functioning, as it may have implications intervention strategies. This study examined whether social cognitive abilities and clinical symptoms are associated with functioning skills.The included 65 UHR patients 30 healthy controls. Social function, skills, a broad range of measures were assessed.The demonstrated decrements on The Awareness...
Cognitive deficits are a distinct feature among people at ultra-high risk (UHR) for psychosis and pose barrier to functional recovery. Insufficient evidence exists on how ameliorate these cognitive in patients UHR hence improve daily living quality of life. The aim the trial is investigate whether remediation can psychosocial function psychosis. FOCUS (Function Overall Cognition Ultra-high States) randomised, parallel group, observer-blinded clinical enrolling 126 meeting standardised...
Objective Neurocognition is known to impact functioning in individuals at ultrahigh risk ( UHR ) for psychosis, but studies investigating potential mediators of this relationship are scarce. Building on evidence from schizophrenia spectrum disorders, the study tested whether negative symptoms and social skills act as between neurocognition functional outcome individuals. Methods Ultrahigh participants N = 84) underwent neurocognitive testing using Brief Assessment Cognition Schizophrenia....
Abstract In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional and individuals at ultra‐high risk for psychosis. One hundred sixteen psychosis 49 matched healthy controls underwent 3 T magnetic resonance diffusion‐weighted imaging assessments. Group differences on fractional anisotropy were tested using tract‐based spatial statistics. functions, voxel‐wise as...
Psychosis spectrum disorders are associated with cerebral changes, but the prognostic value and clinical utility of these findings unclear. Here, we applied a multivariate statistical model to examine predictive accuracy global white matter fractional anisotropy (FA) for transition psychosis in individuals at ultra-high risk (UHR).110 UHR underwent 3 Tesla diffusion-weighted imaging assessments baseline, after 6 12 months. Using logistic regression, examined reliability FA baseline as...
Abstract Aim A significant proportion of individuals at Ultra‐High Risk (UHR) for psychosis do not transition to manifest psychosis. Many non‐transitioning UHR do, however, display poor long‐term outcomes such as persistence attenuated psychotic symptoms. Evidence is scarce on which variables may predict a better clinical and functional prognosis remission from the state. Methods total 146 were enrolled in randomized trial (RCT), with this being analyses secondary RCT. Participants assessed...
The lack of robust neuroanatomical markers psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in measures the majority individuals at may be nested within range observed healthy individuals.
Growing evidence suggests that subtle white matter (WM) alterations are associated with psychopathology in individuals at ultra-high risk for psychosis (UHR). However, the longitudinal relationship between symptom progression and WM changes over time remains under-explored. Here, we examine associations clinical symptoms six months a large UHR-cohort.110 UHR-individuals 59 healthy controls underwent diffusion weighted imaging baseline after months. Group × effects on fractional anisotropy...
Objective To investigate potential clinical differences in high‐risk profiles presenting with and without basic symptoms, additionally the association between symptoms functioning, cognition. Methods High‐risk individuals ( n = 133) were stratified into fulfilling ultra‐high‐risk (UHR) criteria 59) UHR+ (BS) 74). Group assessed on real‐life Regression analyses conducted to elucidate relationship BS neurocognition, social Results The group both had significantly more lower functioning quality...
Abstract A substantial proportion of individuals at ultra-high risk (UHR) for psychosis show long-term functional impairments, which may have profound consequences the individual and society. Finding predictors these impairments is critical to inform on individual’s prognosis potentially develop targeted interventions. This study used data from 91 UHR participating in a randomized, clinical trial, that were followed up 12 months, elucidate clinical, neuro- social-cognitive individuals’...
Cerebral glutamate and gamma-aminobutyric acid (GABA) levels might predict clinical outcome in individuals at ultrahigh risk (UHR) for psychosis but have previously primarily been investigated smaller cohorts. We aimed to study whether baseline of GABA anterior cingulate cortex (ACC) thalamus could remission status metabolites differed the versus nonremission group. also relationship between metabolite severity symptoms, functional outcome, cognitive deficits follow-up.About 124 UHR were...
There is a scarcity of evidence on subjectively reported cognitive difficulties in individuals at ultra-high risk (UHR) for psychosis and whether these self-perceived may relate to objective deficits, psychopathology, functioning, adherence remediation (CR). Secondary, exploratory analyses randomized, clinical trial were conducted with 52 UHR receiving CR intervention. Participants completed the Measure Insight into Cognition-Self Report (MIC-SR), measure daily life within domains attention,...
Background Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated clinical and functional outcome. The effect of cognitive remediation on WM-organization UHR-individuals has not been investigated previously. Methods In a randomized, trial, aged 18-40 years were assigned treatment as usual (TAU) or TAU plus 20 weeks. Cognitive comprised x 2 hours sessions neurocognitive social-cognitive training. Primary...
Abstract Background Ultra‐high risk (UHR) is considered a forerunner of psychosis, but most UHR individuals do not later convert, yet remain symptomatic, disabled and help‐seeking. Thus, there an increased recognition the phenotype as syndrome in itself, rather than merely syndrome. It therefore essential to investigate outcomes other transition psychosis. For this purpose, perceptual aberration appears be distinct, well stable less state‐specific vulnerability indicator. We aimed...