A5064586287- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Pesticide Residue Analysis and Safety
- Insect and Pesticide Research
- Tryptophan and brain disorders
- Mycotoxins in Agriculture and Food
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Prostate Cancer Treatment and Research
- Neurology and Historical Studies
- Obsessive-Compulsive Spectrum Disorders
- Colorectal Cancer Screening and Detection
- Electroconvulsive Therapy Studies
- Prostate Cancer Diagnosis and Treatment
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Hallucinations in medical conditions
- Rabbits: Nutrition, Reproduction, Health
- Neural and Behavioral Psychology Studies
- Fetal and Pediatric Neurological Disorders
- Animal Nutrition and Physiology
Glostrup Hospital
2016-2021
Copenhagen University Hospital
2020
University of Copenhagen
2016-2020
Capital Region of Denmark
2014
Mental Health Services
2014
University of Southern Denmark
2013
Texas A&M University System
2012
Abstract Background Poor response to dopaminergic antipsychotics constitutes a major challenge in the treatment of psychotic disorders and markers for non-response during first-episode are warranted. Previous studies have found increased levels glutamate γ -aminobutyric acid (GABA) non-responding patients compared responders, but it is unknown if non-responders can be identified using reference from healthy controls (HCs). Methods Thirty-nine antipsychotic-naïve with psychosis 36 matched HCs...
Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia may underlie cognitive deficits. However, association between function glutamatergic metabolites has not investigated a large group antipsychotic-naïve patients.In total, 56 patients with or psychotic disorder 51 healthy control subjects underwent magnetic resonance spectroscopy to measure glutamate, glutamate+glutamine (Glx), dorsal anterior cingulate cortex (ACC) Glx left...
Abstract In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional and individuals at ultra‐high risk for psychosis. One hundred sixteen psychosis 49 matched healthy controls underwent 3 T magnetic resonance diffusion‐weighted imaging assessments. Group differences on fractional anisotropy were tested using tract‐based spatial statistics. functions, voxel‐wise as...
To explore whether the diagnostic homogeneity in a daily, routine clinical activity changed visibly over two historical periods (the ICD-8 and ICD-10 era) across within five psychiatric in-patient clinics. In this register study, we analyzed discharge diagnoses from university-affiliated departments of psychiatry Denmark time periods: 1980–1985 (ICD-8) 2001–2010 (ICD-10). The synchronic inter-departmental differences did not decrease era compared with era. Nor diachronic stability each...
Abstract Background The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion patients is before age 18 and after 30 years. While cognitive deficits are considered core features schizophrenia, few studies have directly examined impact illness on cognition. Methods aim study was to examine if effects cognition differ between healthy controls (HCs) at onset. We 156 first-episode antipsychotic-naïve across wide span (12–43...
The current experiment was conducted to determine the effect of mycotoxin-contaminated diets with aflatoxin (AFLA) and deoxynivalenol (DON) dietary inclusion deactivation compound on layer hen performance during a 10-wk trial. experimental design consisted 4 × 2 factorial toxin levels: control, low (0.5 mg/kg AFLA + 1.0 DON), medium (1.5 1.5 high (2.0 2.0 DON) or without compound. Three hundred eighty-four 25-wk-old laying hens were randomly assigned 1 8 treatment groups. Birds fed...
Abstract Background Schizophrenia has been associated with changes in both cortical thickness and surface area, but antipsychotic exposure, illness progression substance use may confound observations. In antipsychotic-naïve schizophrenia patients, we investigated area as well mean curvature before after monotherapy amisulpride, a relatively selective dopamine D 2/3 receptor antagonist. Methods Fifty-six patients 59 matched healthy controls (HCs) underwent T1-weighted 3T magnetic resonance...
An experiment was conducted to determine the effect of dietary inclusion Mycofix Select (Biomin GmbH, Herzogenburg, Austria) on discrete egg parameters and quality characteristics hens fed mycotoxin-contaminated diets (aflatoxin; AFLA) deoxynivalenol (DON)) during a 10-wk trial. A 4 × 2 factorial design used with contamination levels: control, low (0.5 mg/kg AFLA + 1.0 DON), medium (1.5 1.5 high (2.0 2.0 DON) or without mycotoxin deactivating compound. Three hundred eighty-four 25-wk-old...
Background. The use of prostate-specific antigen test has markedly increased in Danish general practice the last decade. Despite national guidelines advice against PSA screening, opportunistic screening is supposed to be primary reason for this number tests performed. Aims. Based on increase amount conducted, we aimed analyse how GPs Denmark test. Methods. A self-administrated questionnaire concerning symptomatic and asymptomatic patient cases was developed based international extensive...
Modern broilers grow much faster and more efficiently than their predecessors. Because of the rapid growth rates broilers, particular attention must be given to skeletal development bird. Calcium formate (CaFo) has been used as a calcium source in animal diets European Union for many years. The objective this study was evaluate CaFo broiler an alternative calcium. Four experimental groups (0.0, 0.5, 1.0, 1.5% CaFo) were evaluated, with 10 replicate pens per treatment. Variables measured...
Background: Animal models of schizophrenia propose that decreased gamma-Aminobutyric acid (GABA)ergic inhibition cortical glutamatergic neurons causes dysfunction in cortico-striato-thalamo-cortical networks. Indeed, disturbances are found anterior cingulate cortex (ACC), thalamus, and striatum antipsychotic-naive patients with schizophrenia. Additionally, increased levels glutamate ACC associated poor treatment response cross-sectional studies. However, GABA studies first-episode sparse...
Higher glutamate levels are found in the anterior cingulate cortex (ACC) of non-responder (NR) patients with schizophrenia cross-sectional studies. However, it remains unclear if this reflects pathophysiology NR or effect antipsychotics and illness chronicity. Also, no previous study has assessed GABA ACC thalamus abnormal from onset. To investigate this, we examined antipsychotic-naïve (SCZ) before after treatment. Longitudinal 38 initially antipsychotic naïve SCZ 34 matched healthy...
Abstract Background Aberrant anticipation of motivational salient events and processing outcome evaluation in striatal prefrontal regions have been suggested to underlie psychosis. Altered glutamate levels likewise linked schizophrenia. Glutamatergic abnormalities may affect the salience evaluation. It remains unresolved, whether glutamatergic dysfunction is associated with coding antipsychotic-naïve patients first-episode Methods Fifty-one psychosis (22 ± 5.2 years, female/male: 31/20) 52...
Background: Schizophrenia is widely associated with brain structural and dopamine receptor abnormalities, but the relation between these parameters unknown. In preliminary analyses, we investigated associations cortical thickness striatal D2/3 binding potentials (BP) changes in antipsychotic-naive patients schizophrenia. Methods: Twenty-six 26 healthy controls underwent 3T Magnetic Resonance Imaging (MRI) [123I]-iodobenzamide Single Photon Emission Computed Tomography (SPECT). 3D T1 image...
Schizophrenia has been associated with changes in both cortical thickness and surface area, but antipsychotic exposure, illness progression, substance use may confound the observations. We investigated as well mean curvature, before after monotherapy a relatively selective dopamine D2/3 antagonist (amisulpride), antipsychotic-naïve schizophrenia patients. Fifty-six patients 59 matched healthy controls (HC) underwent T1-weighted 3T magnetic resonance imaging. Forty-one 51 HCs were re-scanned....
Insufficient response to antipsychotics constitutes a challenge in the treatment of patients suffering from schizophrenia. Treatment resistances have been linked normal striatal dopamine system. We aim stratify antipsychotic-naïve first-episode based on synthesis capacity (DSC) measured with positron emission tomography (PET). hypothesize that who respond an increased DSC at baseline compared non-responders and healthy controls (HC). The current data collected as part multimodal first...
Disturbances in the interacting dopaminergic, glutamatergic and GABAergic systems cortico-striato-thalamo-cortical circuits brain have been implicated pathophysiology of psychosis. Preclinical literature suggests that these disturbances are linked to each other, whereas recent clinical data pointed separate subgroups patients characterized by either or dopaminergic abnormalities. In present study we explore associations between dopamine synthesis capacity glutamate GABA levels...
Individuals at ultra-high-risk for psychosis (UHR) are characterized by decline in cognitive functions. As cognition suggested to be structural dependent on cerebral white matter organization, we here examine, if patterns of functions associated with alterations UHR compared healthy controls (HC). 116 and 49 HCs underwent diffusion weighted imaging using a 3 Tesla magnetic resonance scanner were cognitively assessed. Group differences whole brain fractional anisotropy tested tract-based...
Alterations of the brain reward system have been found in schizophrenia patients and prediction error coding has suggested to underlie formations psychotic symptoms. Prediction errors are discrepancy between what actually happens we expect happen. This misprediction contribute misallocation attention leading generation Recent data from our group shown that thalamic glutamate levels not only heritable linked liability for schizophrenia, but also increased thalamus at illness onset; latter was...
Abstract Background Schizophrenia is suggested to stem from dysfunction of cortico-striato-thalamo-cortical networks. Supporting this, we have recently found increased glutamate levels in thalamus antipsychotic-naïve patients with schizophrenia or psychosis. Moreover, higher baseline were related less improvement psychotic symptoms after treatment. Other groups reported that striatal dopaminergic function psychosis and associated symptoms. Regional cerebral blood flow (rCBF) considered a...