A5037377843- Schizophrenia research and treatment
- Personality Disorders and Psychopathology
- Neurogenesis and neuroplasticity mechanisms
- Mental Health Research Topics
- Genetic Neurodegenerative Diseases
- Cancer Treatment and Pharmacology
- Functional Brain Connectivity Studies
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Mental Health and Psychiatry
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Microtubule and mitosis dynamics
Jeonbuk National University
2022-2025
Chonbuk National University Hospital
2022-2025
Objective Impact of Diagnostic and Statistical Manual Mental Disorders, Fifth Edition (DSM-5) changes on the criteria for schizophrenia (SZ) has been reported to be minimal in previous studies. However, this could different first-episode spectrum disorders (FE-SSDs). We investigated what proportion patients with FE-SSDs was diagnosed based sole presence bizarre delusions (BDs) or first rank auditory hallucinations (FRAHs). Their alternative diagnosis by DSM-5 established diagnostic stability...
Abstract Background Emerging evidence indicates that gene–environment interactions (GEIs) are important underlying mechanisms for the development of schizophrenia (SZ). We investigated associations polygenic risk score SZ (PRS-SZ), environmental measures, and their with case–control status clinical phenotypes among patients spectrum disorders (SSDs). Methods The PRS-SZ 717 SSD 356 healthy controls (HCs) were calculated using LDpred model. Korea-Polyenvironmental Risk Score-I (K-PERS-I) Early...
There are no studies investigating topological properties of resting-state fMRI (rs-fMRI) in patients who have recovered from psychosis and discontinued medication (hereafter, [RP]). This study aimed to explore organization the functional brain connectome RP using graph theory approach. We recruited 30 50 age sex-matched healthy controls (HC). The were further divided into subjects relapsed after discontinuation antipsychotics (RP-R) maintained state without relapse (RP-M). Using graph-based...
Understanding complex epigenetic mechanisms is necessary to fully elucidate the effects of antipsychotic drug. This study investigated DNA methylation and mRNA expression levels dopamine D2 D1 receptor (Drd2 Drd1, respectively), nuclear subfamily 3, group C, member 1 (Nr3c1) stathmin (Stmn1) in brain regions mice exposed social defeat stress (SDS) risperidone on altered induced by SDS.Following SDS for 10 days, (0.2 mg/kg) or vehicle was administered adult 7 days. Brain tissues from...
Epothilone D (EpoD), microtubule (MT) stabilizing agent, demonstrated promising results in the animal models of Alzheimer's disease, Parkinson's disease and schizophrenia. The present study sought to investigate preventive effects EpoD on altered changes MT related proteins endoplasmic reticulum (ER) stress induced by social defeat (SDS). We measured protein expression levels α-tubulin its post-translational modifications, MT-associated 2, stathmin1 2 with their phosphorylated forms, ER...
: Microtubule (MT) stability in neurons is vital for brain development; instability associated with neuropsychiatric disorders. The present study examined the effects of social defeat stress (SDS) on MT-regulating proteins and tubulin polymerization.