A5036193624- Ginseng Biological Effects and Applications
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Graphene and Nanomaterials Applications
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Axon Guidance and Neuronal Signaling
- Sirtuins and Resveratrol in Medicine
- Cell death mechanisms and regulation
- Photoreceptor and optogenetics research
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Genetics and Neurodevelopmental Disorders
- Neuropeptides and Animal Physiology
- Biosensors and Analytical Detection
- RNA modifications and cancer
- Pain Mechanisms and Treatments
Jeonbuk National University
2018-2025
Human Resource Development Center
2023
Chonbuk National University Hospital
2019
St. Jude Children's Research Hospital
2013-2016
Albert Einstein College of Medicine
2010-2015
Yeshiva University
2015
Korea University
2011
Ajou University
2003-2009
Abstract Background In addition to seasonal influenza viruses recently circulating in humans, avian (AIVs) of H5N1, H5N6 and H7N9 subtypes have also emerged demonstrated human infection abilities with high mortality rates. Although viral infections are usually diagnosed using isolation serological/molecular analyses, the cost, accessibility, availability these methods may limit their utility various settings. The objective this study was develop optimized a multiplex detection system for...
Auditory hallucinations in schizophrenia are alleviated by antipsychotic agents that inhibit D2 dopamine receptors (Drd2s). The defective neural circuits and mechanisms of their sensitivity to antipsychotics unknown. We identified a specific disruption synaptic transmission at thalamocortical glutamatergic projections the auditory cortex murine models schizophrenia-associated 22q11 deletion syndrome (22q11DS). This deficit is caused an aberrant elevation Drd2 thalamus, which renders 22q11DS...
Localized drug-delivery systems (LDDSs) are a promising approach for cancer treatment because they decrease systematic toxicity and enhance the therapeutic effect of drugs via site-specific delivery active compounds possible gradual release. However, development LDDS with rationally controlled drug release intelligent functionality holds great challenge. To this end, we have developed tailorable fibrous platform functionalized pH- near-infrared (NIR)-responsive polypyrrole (PPy), aim...
Cortical maps in sensory cortices are plastic, changing response to experience. The cellular site of such plasticity is currently debated. Thalamocortical (TC) projections deliver information cortices. TC synapses dismissed as a locus cortical map because synaptic thought be limited neonates, whereas can induced both neonates and adults. However, the auditory cortex (ACx) adults, if animals attend sound or receive sounds paired with activation cholinergic inputs from nucleus basalis. We now...
Autophagy can result in cellular adaptation, as well cell survival or death. Modulation of autophagy is increasingly regarded a promising cancer therapeutic approach. Ginsenoside compound K (CK), an active metabolite ginsenosides isolated from Panax ginseng C.A. Meyer, has been identified to inhibit growth lines. However, the molecular mechanisms CK effects on and neuroblastoma death have not yet investigated. In present study, inhibited proliferation vitro vivo. Treatment by also induced...
Obesity is considered a health hazard in part due to the associated multiple diseases. As rates of obesity continue increase, new strategy for its prevention and treatment required. Compound-K, an active ingredient ginseng, possesses antioxidant, anti-inflammatory, anti-cancer properties. Although ginseng has used as various therapeutics, potential ability alleviate metabolic diseases by regulating adipocyte differentiation still unknown. In this study, we found that CK significantly...
This study presents a new multifunctional nanofibrous drug delivery system to provide effective combination therapy with enormous potential for the treatment of osteosarcoma. We developed composite nanofiber scaffold comprising poly(ε-caprolactone) (PCL) and hydroxyapatite (HAp)-loaded doxorubicin (DOX) coated polydopamine (PDA) combine cancer cell inhibition bone tissue regeneration. DOX was conjugated HAp then mixed PCL solution prepare PCL/HAp-DOX (labeled PCLDH) nanofiber. Then,
MiRNA (miR)-206 plays a tumor suppressor role in various cancer types. Here, we investigated whether miR-206 is involved prostaglandin E2 (PGE2)-induced epithelial–mesenchymal transition (EMT) colorectal (CRC) cells through the targetting of transmembrane 4 L six family member 1 (TM4SF1). The effect PGE2 on growth and apoptosis CRC was evaluated using MTT assay flow cytometry analysis, respectively. TM4SF1 expression levels were determined with quantitative polymerase chain reaction...
The study presents a controlled nanoscale drug delivery system mediated by polymeric magnetic nanoparticles. Under an alternating field (AMF), the nanoparticles act as internal heating sources that increase surrounding temperature, provoking polymer transitions and thereby releasing entrapped drug. We explain drug-release mechanism using different mathematical models including Higuchi, Korsmeyer–Peppas, Hixson–Crowell, Kopcha. Our results indicate doxorubicin (DOX) release follows...
We present pH-sensitive magnetic nanofibers for thermo-chemotherapy. This approach may offer a versatile, chemo-selective method targeted drug delivery in postsurgical breast cancer treatment.
Abstract Stress management is necessary for vertebrate survival. Chronic stress drives depression by excitation of the lateral habenula (LHb), which silences dopaminergic neurons in ventral tegmental area (VTA) via GABAergic neuronal projection from rostromedial nucleus (RMTg). However, effect acute on this LHb-RMTg-VTA pathway not clearly understood. Here, we used fluorescent situ hybridisation and vivo electrophysiology mice to show that LHb aromatic l -amino acid decarboxylase-expressing...
Regulation of GABAergic inhibitory inputs and alterations in POMC neuron activity by nutrients adiposity signals regulate energy glucose homeostasis. Thus, understanding how neurons integrate these two signal molecules at the synaptic level is important. Here we show that leptin's action on GABA release to influenced levels. Leptin stimulates JAK2–PI3K pathway both presynaptic terminals postsynaptic neurons. Inhibition AMPK decreases 10 mM glucose. However, TRPC channel opening PI3K–PLC...
In the last 10 years, many studies have reported that neural stem/progenitor cells spontaneously produce new neurons in a subset of adult brain regions, including hippocampus, olfactory bulb (OB), cerebral cortex, substantia nigra, hypothalamus, white matter and amygdala several mammalian species. Although neurogenesis hippocampus OB has been clearly documented, its occurrence other regions is controversial. present study, we identified marked accumulation subcallosal zone (SCZ) Bax-knockout...
Ginseng leaves are known to contain high concentrations of bioactive compounds, such as ginsenosides, and have potential a treatment for various conditions, including fungal infections, cancer, obesity, oxidative stress, age-related diseases. This study assessed the impact ginseng leaf extract (GLE) on mast cell-mediated allergic inflammation atopic dermatitis (AD) in DNCB-treated mice. GLE reduced skin thickness lymph node nodules suppressed expression secretion histamine pro-inflammatory...
Neuroblastoma (NB) is the most common childhood cancer, with a very poor prognosis. More than 60% of children NB die within five years; therefore, more effective therapy for required. Although ginsenoside has been shown to significantly inhibit growth various cancers, effect Rk1 on neuroblastoma not known yet. Hence, we examined anticancer effects highly pure cell lines. The apoptotic cells were using viability assay, flow cytometry and staining change in gene expression levels analysed...
Cognitive impairment can be associated with reduced adult hippocampal neurogenesis, and it may contribute to age-associated neurodegenerative diseases such as Alzheimer’s (AD). Compound K (CK) is produced from the protopanaxadiol (PPD)-type ginsenosides Rb1, Rb2, Rc by intestinal microbial conversion. Although CK has been reported an inducing effector for neuroprotection improved cognition in hippocampus, its effect on neurogenesis not explored yet. Here, we investigated of both young (2...
Prostate cancer is one of the most common cancers in world. It widely known that prostate-specific membrane antigen (PSMA) highly expressed prostate cancer, and hypoxia a characteristic many solid tumors, including cancer. In this study, we designed multifunctional fluorescent inhibitors to target PSMA tumor order increase uptake inhibitors. Novel were prepared using lysine as backbone connect three different functional groups: glutamate-urea-lysine (GUL) structure for inhibiting PSMA,...