Although the use of intra-articular polynucleotide (IA PN) injection as a viscosupplement for knee osteoarthritis (OA) treatment has been proposed, its efficacy and safety compared to high molecular weight hyaluronic acid (HMWHA) not yet established. The present double-blind, multicenter, randomized controlled trial aimed investigate IA PN HMWHA injection. A total 60 patients (15 men, 45 women, 64.5 ± 7.5 years) with OA (Kellgren-Lawrence grade 1-4) were randomly allocated each group. All...

In the last 10 years, many studies have reported that neural stem/progenitor cells spontaneously produce new neurons in a subset of adult brain regions, including hippocampus, olfactory bulb (OB), cerebral cortex, substantia nigra, hypothalamus, white matter and amygdala several mammalian species. Although neurogenesis hippocampus OB has been clearly documented, its occurrence other regions is controversial. present study, we identified marked accumulation subcallosal zone (SCZ) Bax-knockout...

During early postnatal development, the orchestrated regulation of proliferation, migration and survival versus elimination neurons is essential for histogenesis cerebellum. For instance, Purkinje cells (PCs) promote proliferation external granule (EGCs), whereas EGCs in turn play a role PCs. Considering that substantial number undergo programmed cell death (PCD) during cerebellar it seems likely neuronal loss could have significant To address this question, we examined development...

Recently, there has been a trend toward minimizing opioid use in obese patients to prevent opioid-related postoperative complications. Moreover, the of opioid-free anesthesia received growing interest. This case series reports simple consisting mixture dexmedetomidine, ketamine, and lidocaine an male patient undergoing laparoscopic bariatric surgery pregnant woman cesarean section. These cases indicate that can be safely administered provides effective pain control without any adverse outcomes.

Vasopressin is a locally-injected vasoconstrictor used to reduce bleeding during gynaecological surgery. However, even in these cases, vasopressin can induce adverse effects, including bradycardia, myocardial infarction and cardiac arrest. Elevated blood concentrations of may the sympathoinhibitory reflex by increasing pressure augment activating area postrema. In addition, pneumoperitoneum formation needed for laparoscopy as well physiological changes caused steep Trendelenburg positions...

Antiphospholipid syndrome (APS) is an acquired thrombotic autoimmune disorder that clinically characterized by the development of thrombosis and obstetric morbidities in patients with antiphospholipid antibodies. Due to hypercoagulability, focus management anticoagulation for prevention its recurrence. When such undergo surgery, however, underlying risk increases as a result anticoagulant withdrawal, immobilization, and/or intimal injury. Conversely, there also increased bleeding due...

Amniotic fluid embolism (AFE) is a rare disease, but it potentially fatal condition, as well leading cause of unpredictable maternal death in developed countries. The typical clinical symptoms AFE include hypoxia, hypotension, and coagulopathy, with rapid progression, may cardiac arrest death. We report case sudden hemodynamic instability due to amniotic embolism, which was successfully treated veno-arterial extracorporeal membrane oxygenation (ECMO). A 39-year-old woman scheduled for...

A 21-year-old man underwent wedge resection for treatment of pneumothorax. This patient had been diagnosed with Charcot-Marie-Tooth disease (CMTD) and a history surgical scoliosis, pneumothorax, foot deformity, arm dislocation. Additionally, the showed signs muscle weakness atrophy in upper lower extremities. CMTD is genetically associated motor sensory neuropathy reportedly has an association malignant hyperthermia or delayed relaxation mechanism. In present case, total intravenous...

Vasopressin local infiltration is useful in gynecological surgery because it can reduce hemorrhage. Depending on the activities of sympathetic system and renin–angiotensin system, reactions to vasopressin may differ predicting its systemic effects difficult. Because life-threatening complications occur, with should be administered caution. A 42-year-old female patient was diagnosed uterine leiomyomas. During a robot-assisted laparoscopic myomectomy, 50 U vasopressin, which ten-times...

Therapeutic hypothermia is often used for traumatic brain injury because of its neuroprotective effect and decreased secondary injury. However, this procedure lacks clinical evidence supporting efficacy, adverse outcomes have been reported during general anesthesia. A 61-year-old man with a history percutaneous coronary intervention (PCI) was admitted Immediately after admission, he underwent mild therapeutic target temperature 33.0°C neuroprotection. During anesthesia emergency surgery...

We studied the anti-diabetic effects of medicinal herb water extracts on expression hepatic glucokinase (GCK), pyruvate dehydrogenase (PDH), and acetyl-CoA carboxylase (ACC) mRNA. The herbs used for experiments were Cornus officinalis (CO), Paeonia suffruticosa Andrews (PSA), Discorea japonica Thunb. (DJ), Rehmannia glutinosa (RG), Lycium chinense (LC), Pyrus pyrifolia (PP). For GCK mRNA expression, CO, RG, LC exhibited a more effective activity than other extracts. Cells treated with RG...

본 연구에는 고추씨기름, 녹차씨기름, 들깨기름, 땅콩기름, 목화씨기름, 참깨기름, 호두기름, 홍화씨기름의 fatty acid 구성을 분석하여 oleic acid, linoleic 등의 불포화 지방산이 과반이상 함유되어 있음을 확인하였으며 들깨기름은 특이하게 linolenic acid(57.8%)가 함유된 것을 확인할 수 있었다. 원재료의 일반성분과 추출한 기름의 품질을 측정하여 식용유 및 튀김용 기름으로 사용하기에 식품공전의 식용유지 튀김용유지의 기준 규격에 잠재적으로 적합함을 확인하였다. 또한 종실유들의 생리활성을 예측하기위해 세포독성, 지방축적 leptin 방출에 미치는 영향을 측정하였다. 그 결과 실험에 사용된 모든 종실유가 0.2 mg/mL 이하에서 독성이 나타나지 않았으며, 고추씨기름(67%, 0.05 mg/mL), 들깨기름(63%, mg/mL; 72%, 0.1 땅콩 기름(58%, 68%, mg/mL)의 처리가 통계적으로 유의한 수준(p<0.01, p<0.001)에서...

Increasing evidence suggests that olfactory impairment is associated with an increased risk of conversion from mild cognitive (MCI) to Alzheimer's disease. To explore how performance relate white matter (WM) integrity, diffusion tensor imaging (DTI) was acquired individuals (MCI). DTI performed thirteen MCI (mean age: 68.31 ± 8.83 years). Olfactory assessed using the Brief Smell Identification Test (B-SIT). Cross-sectional voxel-wise analyses relationships between B-SIT and indices were...

Background and objectives A recent study has reported that Zanthoxylum schinifolium Sieb. et Zucc. anti‐atherosclerotic properties. Therefore, the present investigates therapeutic potential of Sielb. seed oil (ZSO) on blood lipid profile obesity, which causes atherosclerosis, in Sprague Dawley (SD) rats fed a high‐cholesterol high‐fat (HCHF) diet. Additionally, lipolytic effects ZSO were investigated using 3T3‐L1 adipocytes.. Materials Methods The composition was determined by gas...

Background and Objectives:Direct stenting (DS) has been shown to be safe feasible, with demonstrable reductions in cost, procedural time radiation exposure, may also result less vessel injury. The aim of this study was compare the immediate six month clinical angiographic outcomes direct stent implantation following balloon predilatation (conventional stenting, CS). Subjects Methods:Between July 2001 June 2004, 266 patients (293 lesions) angina pectoris were included study. Patients having...

선천성 무통증과 무한증(congenital insensitivity to pain with anhidrosis, CIPA)은 매우 드문 유전성 질환으로 제4형 감각자 율신경병증(hereditary sensory and autonomic neuropathy, HSAN Ⅳ)이라고도 불리며 통각과 온각이 소실되고 발한 기능이 없거나 감소되는 질환이다. 1) 영아기부터 시작되는 불명열을 비롯한 다양 한 전신적인 증상을 보이며 정형외과적으로 보았을 때 수지 말단 부 절단, 신경병성 관절증, 변형이나 가관절증을 동반하기도 하는 재발성 골절, 무혈성 괴사, 골수염, 화농성 관절염 등의 보 인다. 2) 저자들은 수상 시기를 알 수 없는 우측 원위 대퇴골 골절 로 내원한 환자를 치료하는 과정 중에 CIPA로 진단하였고, 그 경 험을 문헌 고찰과 함께