A5100626450- Hemostasis and retained surgical items
- Surgical Sutures and Adhesives
- Acute Ischemic Stroke Management
- Electrospun Nanofibers in Biomedical Applications
- Cerebrovascular and Carotid Artery Diseases
- Monoclonal and Polyclonal Antibodies Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cognitive Functions and Memory
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Protein Kinase Regulation and GTPase Signaling
- Cellular transport and secretion
- Stroke Rehabilitation and Recovery
- Advanced Biosensing Techniques and Applications
- Olfactory and Sensory Function Studies
- HER2/EGFR in Cancer Research
- Cardiac Imaging and Diagnostics
- Estrogen and related hormone effects
- Foreign Body Medical Cases
- Reconstructive Surgery and Microvascular Techniques
- Microbial Natural Products and Biosynthesis
- Pancreatic function and diabetes
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Thyroid Cancer Diagnosis and Treatment
Daejeon St. Mary's Hospital
2011-2023
Catholic University of Korea
1998-2023
Daegu-Gyeongbuk Medical Innovation Foundation
2019-2022
Gyeongbuk Marine Bio-Industry Research Institute
2021
Kyungpook National University
2021
Black Hills State University
2021
Neurology, Inc
2019
Pusan National University Yangsan Hospital
2017
National Institutes of Health
1995-2010
National Cancer Institute
2008-2010
The expression of human epidermal growth factor receptor-2 (HER2) receptors in cancers is correlated with a poor prognosis. If assessed vivo, it could be used for selection appropriate therapy individual patients and monitoring the tumor response to targeted therapies. We have radiolabeled HER2-binding Affibody molecule fluorine-18 vivo HER2 by positron emission tomography (PET).
The relationship between the ability of isolated pleckstrin homology (PH) domains to bind inositol lipids or soluble phosphates in vitro and localize cellular membranes live cells was examined by comparing PH phospholipase Cδ1 (PLCδ1) recently cloned PLC-like protein p130 fused green fluorescent (GFP). prominent membrane localization PLCδ1PH-GFP paralleled with high affinity binding 1,4,5-trisphosphate (InsP3) as well phosphatidylinositol 4,5-bisphosphate-containing lipid vesicles...
Complementary DNAs encoding a previously unidentified phosphoinositide-specific phospholipase C (PLC) isozyme were cloned from rat brain cDNA library by the polymerase chain reaction with degenerate oligonucleotide primers based on sequences common to three known δ;-type PLC isozymes. The encoded polypeptide contains 772 amino acids (calculated molecular mass, 88,966 daltons) and is similar in primary structure isozymes, overall sequence identities of 45% PLC-δ;1, 72% PLC-δ;2, 47% PLC-δ;3....
For MR perfusion-diffusion (PWI-DWI) mismatch to become routine in thrombolysis patient selection, rapid and reliable assessment tools are required. We examined interrater variability PWI/DWI volume measurements developed a tool based on the Alberta Stroke Program Early CT Scores (ASPECTS) system.DWI PWI were performed 35 patients with stroke <6 hours after symptom onset. DWI lesion (time peak) volumes measured planimetric techniques by 4 raters 95% limits of agreement calculated. ASPECT...
The diagnostic relevance of subjective memory complaints (SMCs) in mild cognitive impairment (MCI) remains to be unresolved. aim this study is determine clinical correlates SMCs MCI. Furthermore, we examined whether there are the differences due different aspects (i.e. prospective (PM) versus retrospective (RM) complaints).We cross-sectional associations between and depressive symptoms, instrumental activities daily living (IADL), measures sixty-six individuals with MCI (mean age: 65.7 ±...
The development of highly sensitive, stable, and biocompatible imaging agents allowing visualization dendritic cell (DC) migration is one the essential factors for effective DC-based immunotherapy. Here, we used a novel efficient synthesis approach to develop radioiodine-124-labeled tannic acid gold core–shell nanoparticles (124I-TA-Au@AuNPs) DC labeling in vivo tracking their using positron emission tomography (PET). 124I-TA-Au@AuNPs were produced within 40 min high yield via...
Background and Purpose— The Alberta Stroke Program Early CT Score (ASPECTS) is a validated method of assessing parenchymal ischemic changes, including focal swelling hypoattenuation. hypothesis that these signs result from different pathophysiological processes was tested by comparing with diffusion perfusion- weighted MRI. Methods— MRI were performed, within 2 hours each other, in 30 stroke patients <17 after symptom onset. Relative apparent coefficient, relative cerebral blood flow,...
Abstract Objectives This study evaluated the collateral map’s ability to predict lesion growth and penumbra after acute anterior circulation ischemic strokes. Methods was a retrospective analysis of selected data from prospectively collected database. The ratio follow-up volume baseline on diffusion-weighted imaging (DWI). time-to-maximum (Tmax)/DWI Tmax > 6 s volume. hypoperfused phase_FU (phase with lesions most approximate DWI lesion) phase_baseline map. Multiple logistic regression...
Regulator of G-protein signaling 3 (RGS3) enhances the intrinsic rate at which Gαi and Gαq hydrolyze GTP to GDP, thereby limiting duration in GTP-Gαi GTP-Gαq can activate effectors. Since GDP-Gα subunits rapidly combine with free Gβγ reform inactive heterotrimeric G-proteins, RGS3 other RGS proteins may also reduce amount available for effector interactions. Although RGS6, RGS7, RGS11 bind Gβ5 absence a Gγ subunit, are not known directly influence signaling. Here we show that binds Gβ1γ2...
Abstract Purpose: New strategies to restore sodium iodide symporter (NIS) expression and function in radioiodine therapy–refractive anaplastic thyroid cancers (ATCs) are urgently required. Recently, we reported the regulatory role of estrogen-related receptor gamma (ERRγ) ATC cell NIS function. Herein, identified DN200434 as a highly potent (functional IC50 = 0.006 μmol/L), selective, orally available ERRγ inverse agonist for enhancement ATC. Experimental Design: We sought identify better...
Human epidermal growth factor receptor 2 (HER2) overexpression in breast cancers is associated with poor prognosis and resistance to therapy. Current techniques for estimating this important characteristic use ex vivo assays that require tissue biopsies. We suggest a novel noninvasive method characterize HER2 expression vivo, using optical imaging, based on HER2-specific probes (albumin-binding domain–fused-(Z HER2:342)2 -Cys Affibody molecules [Affibody AB, Solna, Sweden], labeled Alexa...
Background Collateral circulation determines tissue fate and affects treatment result in acute ischemic stroke. A precise method for collateral estimation an optimal imaging protocol is necessary to make appropriate decision Purpose To verify the value of multiphase data sets (MR angiography map) derived from dynamic contrast material–enhanced MR predicting functional outcomes after Materials Methods This secondary analysis ongoing prospective observational study included participants with...
Abstract To determine the value of susceptibility-weighted imaging (SWI) for collateral estimation and predicting functional outcomes after acute ischemic stroke. identify independent predictors favorable outcomes, age, sex, risk factors, baseline National Institutes Health Stroke Scale (NIHSS) score, diffusion-weighted (DWI) lesion volume, site steno-occlusion, SWI grade, mode treatment, successful reperfusion were evaluated by multiple logistic regression analyses. A total 152 participants...
The long-term survival rate of gastric cancer patients after surgery has recently increased as a result making an early diagnosis cancer. Therefore, the incidence remnant is increasing. This study was performed to evaluate clinicopathological characteristics and prognosis with cancer.From January 2005 December 2009, twenty-nine who underwent at Pusan National University Hospital were enrolled in this study. We retrospectively reviewed analyzed their medical records. also divided them into...
An inverse agonist of estrogen-related receptor-γ (ERRγ), an orphan nuclear receptor encoded by Esrrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to therapy vitro. We synthesized potent, selective, and orally bioavailable ERRγ-inverse agonists evaluated their activity analyzing vitro pharmacology absorption, distribution, metabolism, excretion, toxicity profiles. X-ray crystallographic analysis...
Assessment of the collateral status has been emphasized for appropriate treatment decisions in patients with acute ischemic stroke. The purpose this study was to introduce a multiphase MRA imaging method (collateral map) derived from time-resolved dynamic contrast-enhanced and verify value map stroke by comparing it (MRP susceptibility MR perfusion. From prospectively maintained registry stroke, data caused steno-occlusive lesions unilateral ICA and/or M1 segment MCA were analyzed. We...
The filamentous fungal pathogen Fusarium sp. causes several crop diseases. Some are endophytes that produce diverse valuable bioactive secondary metabolites. Here, extensive chemical investigation of the endophytic fungus, QF001, isolated from inner rotten part old roots Scutellariae baicalensis resulted in isolation two new photosensitive geometrical isomers lucilactaene (compounds 2 and 3) along with (6) six other known compounds (fusarubin (1), (+)-solaniol (4), javanicin (5),...
Thromboembolic events related to CAS continue be the main limitation widespread use of this technique as a first-line treatment for carotid occlusive disease. Our aim was evaluate thromboembolism during using DWI catheterization techniques artery.Thirty-two consecutive patients with symptomatic stenosis underwent involving 1 2 artery techniques: One used 7F or 8F catheter (group 1, n = 16) and other coaxial system in which conjunction 4F 5F 2, 16). performed before after CAS. Clinical...
The inositol lipid and phosphate binding properties the cellular localization of phospholipase Cdelta(4) (PLCdelta(4)) its isolated pleckstrin homology (PH) domain were analyzed in comparison with similar features PLCdelta(1) protein. PH domains both proteins showed plasma membrane when expressed form a green fluorescent protein fusion construct various cells, although significantly lower proportion PLCdelta(4) was membrane-bound than case PLCdelta(1)PH-GFP. Both selectively recognized...
Collateral circulation is associated with the differential treatment effect of endovascular thrombectomy (EVT) in acute ischemic stroke. We aimed to verify ability collateral map predict futile EVT patients anterior
Butenolides are a family of lactones containing double bond and have been frequently found in the extracts Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered isolated from culture broth marine-derived sp. 13G036 based on molecular networking analysis. Among isolates, compound 7 was first as natural product study. The structures compounds 1–7 determined by combined analysis 1D/2D Nuclear Magnetic Resonance (NMR)...