A5032431059- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Microbial Natural Products and Biosynthesis
- Medical Imaging Techniques and Applications
- Computational Drug Discovery Methods
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Natural product bioactivities and synthesis
- Curcumin's Biomedical Applications
- Inflammatory mediators and NSAID effects
- Fungal Biology and Applications
- Biochemical Analysis and Sensing Techniques
- Marine Sponges and Natural Products
- Bone Tissue Engineering Materials
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Phytochemistry and Biological Activities
- Vibrio bacteria research studies
- Orthopaedic implants and arthroplasty
- HER2/EGFR in Cancer Research
- Color perception and design
Yeungnam University
2021-2024
Lutron Electronics (United States)
2023
Korea University
2022
Liver fibrosis, which means a sort of the excessive accumulation extracellular matrices (ECMs) components through liver tissue, is considered as tissue repair or wound-healing status. This pathological stage potentially leads to cirrhosis, if not controlled, it progressively results in hepatocellular carcinoma. Herein, we investigated pharmacological properties and underlying mechanisms Gardeniae Fructus (GF) against thioacetamide (TAA)-induced fibrosis mice model. GF only attenuated hepatic...
Epidemic diseases that arise from infectious RNA viruses, particularly influenza pose a constant threat to the global economy and public health. Viral evolution has undermined efficacy of acquired immunity vaccines antiviral effects FDA-approved drugs. As such, there is an urgent need develop new lead agents. Natural compounds, owing their historical validation application safety, have become promising solution. In this light, novel marine bacterium, Pseudomonas sp. M20A4R8, been found...
Epidemic diseases that arise from infectious RNA viruses, particularly influenza pose a constant threat to the global economy and public health. Viral evolution has undermined efficacy of acquired immunity vaccines antiviral effects FDA-approved drugs. As such, there is an urgent need develop new lead agents. Natural compounds, owing their historical validation application safety, have become promising solution. In this light, novel marine bacterium, Pseudomonas sp. M20A4R8, been found...
Butenolides are a family of lactones containing double bond and have been frequently found in the extracts Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered isolated from culture broth marine-derived sp. 13G036 based on molecular networking analysis. Among isolates, compound 7 was first as natural product study. The structures compounds 1–7 determined by combined analysis 1D/2D Nuclear Magnetic Resonance (NMR)...
Chemical investigations of Aquimarina sp. MC085, which suppressed TGF-β-induced epithelial–mesenchymal transition (EMT) in A549 human lung cancer cells, led to the isolation compounds 1–3. Structural characterization using spectroscopic data analyses combination with Marfey’s analysis revealed that they were two diketopiperazines [cyclo(l-Pro-l-Leu) (1) and cyclo(l-Pro-l-Ile) (2)] one N-phenethylacetamide (3). Cyclo(l-Pro-l-Leu) N-phenethylactamide (3) inhibited TGF-β/Smad pathway metastasis...
Despite the importance of tumor-infiltrating lymphocytes (TIL) and PD-L1 expression to immune checkpoint inhibitor (ICI) response, a comprehensive assessment these biomarkers has not yet been conducted in neuroendocrine neoplasm (NEN). We collected 218 NENs from multiple organs, including 190 low/intermediate-grade 28 high-grade NENs. TIL distribution was derived Lunit SCOPE IO, an artificial intelligence (AI)-powered hematoxylin eosin (H&E) analyzer, as developed 17,849 whole slide images....
Wear particle‑induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The control excessive osteoclast differentiation and inflammation essential for protecting against wear osteolysis. present study evaluated effect britanin, pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis vitro Ti vivo. britanin was examined mouse bone marrow‑derived macrophages...
Abstract Background: Previously, AI-powered spatial tumor-infiltrating lymphocyte analysis in H&E whole-slide image (WSI) showed promising performance predicting ICI outcomes. However, there were several innate limitations of tissue analysis, including the time lag between biopsy and actual administration, during which tumor microenvironment (TME) has changed, analyzing a part single would not fully assess immunogenicity multiple metastatic tumors. To overcome challenges, we developed...
Abstract Introduction: HER2 (ERBB2) is a target for various anti-cancer therapies, including large (Trastuzumab deruxtecan) or small molecules (Neratinib). Quantitative assessment of expression at the cellular level may improve therapeutic efficacy prediction. While ERBB2 mutations are known oncogenic drivers, their impact on tumor cell unclear. In this study, we focused common mutations, and analyzed via AI-powered image analysis in pan-cancer specimens to identify possible...
Abstract Background: Contactin-4 (CNTN4) has been identified as an inhibitory immune checkpoint protein and mainly expressed on tumor cells. It interacts with APP present in T cells, leading to a reduction cell proliferation, activation, responsiveness tumors. In this study, we applied artificial intelligence (AI)-powered analyzers examine the expression of CNTN4 its association PD-L1 various solid Methods: The AI-powered immunohistochemistry (IHC) were developed using pan-cancer whole slide...
e13569 Background: Immunotherapy has become the treatment of choice for first-line unresectable NSCLC with high PD-L1 tumor proportion score (TPS). However, optimal regimen, particularly when to add chemotherapy, remains unclear. To evaluate whether an immune microenvironment biomarker could help guide we have explored computational hypothetical analysis applying historical inflamed phenotype (IIP) published outcome data clinical trials. Methods: R package “IPDfromKM” was used reconstruct...
571 Background: The recurrence risk (RS) based on transcriptomic profiles or Ki-67 level of HR+ EBC has been used for adjuvant treatment decisions and may also aid selecting patients who could benefit from novel treatments including CDK4/6 inhibitor oral selective estrogen receptor degraders (SERDs). Artificial intelligence-powered H&E whole slide image (WSI) models can be a practical approach this biomarker without the need additional tissue samples. We developed ML-based...
8536 Background: Immune checkpoint inhibitors (ICI) are an integral part of the treatment for advanced or metastatic non-small cell lung cancer (NSCLC). Chest CT and pathology data is gathered in routine clinical practice, each modality provides complementary information. Tumor microenvironment spatially heterogeneous temporally dynamic. images provide macro-level characteristics multiple tumors, tissue-based histopathologic biomarkers analyze a single representative tumor in-depth. We...
<h3>Background</h3> Tumor-infiltrating lymphocytes (TILs) serve as both prognostic and predictive biomarker in triple-negative breast cancer (TNBC). TNBC exhibits six distinct molecular subtypes —basal-like 1, basal-like 2, mesenchymal, mesenchymal stem-like, immunomodulatory (IM), luminal androgen receptor— which have clinical implications terms of treatment response.<sup>1 2</sup> In this study, we investigated the TIL distribution TNBC, along with their association driver mutations....
e16214 Background: Immune checkpoint inhibitors (ICIs) have shown promising treatment outcomes for various types of tumors. However, in neuroendocrine tumors and carcinomas (NET/NEC), ICI has proven to be applicable only limited cases. In addition, little is known about the immunoprofile NET/NEC. Here we investigate landscape tumor-infiltrating lymphocytes (TIL) using artificial intelligence (AI)-powered H&E whole-slide image (WSI) analyzer elucidate tumor microenvironment Methods: A...
The effect of visual information on taste association is very high. Among the factors that influence this view, most diversely used can be color. Recent research and color has been actively conducted but them have about colors using concentration flat samples or drinks. However type object we actually associate with 3D. Therefore, would like to learn how surface characteristics affect in 3D considering properties. An experiment strength associated sweetness, sourness, bitterness, salty was...