A5031448491- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Hepatitis C virus research
- Receptor Mechanisms and Signaling
- Health and Wellbeing Research
- Liver Disease and Transplantation
- Stress Responses and Cortisol
- Diverse Approaches in Healthcare and Education Studies
- Tryptophan and brain disorders
- Neuroscience and Neural Engineering
- Growth Hormone and Insulin-like Growth Factors
- Hepatitis B Virus Studies
- Neural dynamics and brain function
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Sedative Agents
- Cholinesterase and Neurodegenerative Diseases
- Healthcare Education and Workforce Issues
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Renal cell carcinoma treatment
- Nicotinic Acetylcholine Receptors Study
- Traumatic Brain Injury and Neurovascular Disturbances
- Organ Transplantation Techniques and Outcomes
- Medical Imaging and Pathology Studies
Korea University
2002-2024
The University of Texas at Austin
2021-2024
University of California, Los Angeles
2024
Seoul Veterans Hospital
2001-2023
Universiti of Malaysia Sabah
2023
Voluntary Health Services Hospital
2013
Samsung Medical Center
2010
Sungkyunkwan University
2010
Norwegian Womens Public Health Association
2001
Ulsan College
2000-2001
Crohn's disease (CD) and ulcerative colitis (UC) are considered rare diseases in developing countries. We have evaluated the incidence prevalence of CD UC over time a district Seoul, Korea.A population-based study was performed from 1986 to 2005 Songpa-Kangdong Seoul. To recruit patients as completely possible, multiple information sources, including all medical facilities area 3 referral centers nearby but outside area, were used.During 20-year period, 138 incident cases (102 men, 36 women)...
Investigation and modulation of neural circuits in vivo at the cellular level are very important for studying functional connectivity a brain. Recently, probes with stimulation capabilities have been introduced, they provided an opportunity activities specific region brain using various stimuli. However, previous methods limitation dissecting long-range due to inherent limitations on their designs. Moreover, large size previously reported induces more significant tissue damage. Herein, we...
<i>Objectives:</i> Although hepatitis B virus (HBV) is endemic to Korea, no large-scale survey of HBV genotypes and serotypes based on sequence analysis has been performed. <i>Methods:</i> In the present study, we genotyped serotyped strains from 209 patients in two Korean regions, Seoul (107 patients) Jeju (102 patients), an island off southeastern coast. Analyses were conducted using direct sequencing method targeting partial surface (S) gene (541 bp)....
Real-time monitoring of various neurochemicals with high spatial resolution in multiple brain regions vivo can elucidate neural circuits related to diseases. However, previous systems for have limitations observing without crosstalk real time, and these methods cannot record electrical activity, which is essential investigating circuits. Here, we present a real-time bimodal (RTBM) probe that uses monolithically integrated biosensors shanks study the connectivity by measuring activity time....
Background Bile duct injuries after transarterial chemoembolization (TACE) have been reported; however, the exact pathogenic mechanisms and clinical implications of remain to be clarified. Study A total 950 consecutive patients with hepatocellular carcinoma (HCC) were studied. Among them, 807 treated TACE remaining 143 chemoinfusion (TACI) cisplatin. Results None HCC TACI found any radiographic evidence biliary injury. In contrast, TACE, 17 (2%) developed complications. Of all complications,...
Abstract Dysfunction of cholinergic signaling in the brain has long been believed to be associated with depressive disorders. However, functional impact habenular on specified behaviors is not well understood. Here, we demonstrated that expression levels genes (CHAT, VACHT, CHT, CHRNA3, CHRNB3 and CHRNB4) were down-regulated a chronic restraint stress (CRS) rat model depression, which rats display depression-like such as anhedonia mood despair. Moreover, knockdown CHAT habenula was...
The aim of this study was: (i) to define the characteristics hepatocellular carcinoma (HCC) associated with recurrences following initial remission by transcatheter arterial chemoembolization (TACE); (ii) evaluate patterns recurrences; and (iii) find a better surveillance method detecting recurrent HCC.Out 230 consecutive HCC patients who underwent TACE, 77 were followed prospectively for at least 12 months. We compared recurrence rates according tumors analyzed locations HCC. diagnostic...
Abstract Background DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-110, is an excitatory scaffolding protein that interacts with synaptic surface receptors and signaling molecules. A recent study has demonstrated mutations in the DLG2 promoter region are significantly associated autism spectrum disorder (ASD). Although well a schizophrenia-susceptibility gene, mechanisms link gene disruption ASD-like behaviors remain unclear. Methods Mice lacking exon 14 of Dlg2 (...
Abstract Stress management is necessary for vertebrate survival. Chronic stress drives depression by excitation of the lateral habenula (LHb), which silences dopaminergic neurons in ventral tegmental area (VTA) via GABAergic neuronal projection from rostromedial nucleus (RMTg). However, effect acute on this LHb-RMTg-VTA pathway not clearly understood. Here, we used fluorescent situ hybridisation and vivo electrophysiology mice to show that LHb aromatic l -amino acid decarboxylase-expressing...
The habenula (Hb) is an epithalamic structure that links multiple forebrain areas with the mid/hindbrain monoaminergic systems. As anti-reward center, it has been implicated in etiology of various neuropsychiatric disorders, particularly those associated dysregulated reward circuitry. In this regard, Hb proposed as a therapeutic target for treatment-resistant depression higher risk suicide. Therefore, we aimed to gain insight into molecular signatures association suicide individuals major...
Mutation of p53 is a poor prognostic indicator hepatocellular carcinoma (HCC). Although histologic differentiation HCC has been associated with mutations, the exact reasons for unfavorable clinical outcomes in patients remain to be clarified. In this study, we evaluate association between mutation and histopathologic features HCCs, as well tumor recurrences survival. We examined 20 HCCs surrounding liver tissues from who underwent surgical resection, performed direct sequencing gene....
BACKGROUND Hypoxia up-regulates insulin-like growth factor-2 (IGF-2) and thus stimulates the of hepatocellular carcinoma (HCC) cells. In current study, authors prospectively evaluated changes in plasma IGF-2 levels HCC patients after transcatheter arterial chemoembolization (TACE), which usually results hypoxic insult to liver tissue. The also examined association between TACE progression, especially relation metastasis. METHODS Plasma were measured before 4 weeks 46 with HCC. Three months...
Lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3) is known to be a useful marker for the diagnosis of hepatocellular carcinoma (HCC). Recent studies have shown that positive AFP-L3 results after treatment predicts tumor recurrence and poor clinical outcome. This study was evaluate role pretreatment as prognostic response transcatheter arterial chemoembolization (TACE) survival in patients with HCC. Forty-six HCC who underwent TACE were analyzed. Agglutinin-reactive AFP measured...
Osteopontin (OPN) is overexpressed in hepatocellular carcinoma (HCC) with postoperative recurrence or extrahepatic metastasis. However, its prognostic value patients treated transarterial chemoembolization (TACE) unclear. We investigated the utility of serum OPN levels and changes therein as markers HCC who have received TACE.Forty-six were enrolled. Serum measured before 4 weeks after TACE. biochemistry computed tomography (CT) scans analyzed. evaluated baseline subsequent relation to tumor...
Calcium-dependent secretion activator 2 (CAPS2) regulates the trafficking and exocytosis of neuropeptide-containing dense-core vesicles (DCVs). CAPS2 is prominently expressed in medial habenula (MHb), which related to depressive behavior; however, how MHb neurons cause symptoms role remains unclear. We hypothesized that dysfunction CAPS might defects neuropeptide activity monoaminergic centers, resulting depressive-like behaviors. In this study, we examined (1) expression depression animal...
Chronic stress contributes to the risk of developing depression; habenula, a nucleus in epithalamus, is associated with many neuropsychiatric disorders.Using genome-wide gene expression analysis, we analyzed transcriptome habenula rats exposed chronic restraint for 14 days.We identified 379 differentially expressed genes (DEGs) that were affected by stress.These enriched neuroactive ligand-receptor interaction, cAMP (cyclic adenosine monophosphate) signaling pathway, circadian entrainment,...
The habenula (Hb) is small but important brain structure, anatomically and functionally links the forebrain with midbrain to modulate various neuropsychiatric functions associated drug addiction emotion-associated dysfunctions. Several reports suggested that dysfunction of Hb-related affected Hb structurally functionally. However, technical limitation has awaited solid conclusion whether change due depression likely occur in certain subnuclei Hb. To probe this possibility, we developed...
Transcranial brain stimulation is a promising technology for safe modulation of function without invasive procedures. Recent advances in transcranial optogenetic techniques with external light sources, using upconversion particles and highly sensitive opsins, have shown promise precise neuromodulation improved spatial resolution deeper regions. However, these methods not yet been used to selectively excite or inhibit specific neural populations multiple In this study, we created wireless...
Abstract High-grade dysplastic nodules (HGDNs) are known to be premalignant lesions of hepatocellular carcinoma (HCC). We devised a model estimate the long-term survival benefit treating HGDNs by radiofrequency ablation (RFA) (Group I), as compared with regular follow-up and timely treatment resection II). A hypothetical 60-year-old compensated patient cirrhosis was assumed. The system being modeled assumed simple Markov process, state transition probabilities were given parameters. Data...
Background/Aims: Despite the availability of direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection in Korea, need remains pangenotypic regimens that can be used presence hepatic impairment, comorbidities, or prior treatment failure. We investigated efficacy and safety sofosbuvir–velpatasvir sofosbuvir–velpatasvir–voxilaprevir 12 weeks HCV-infected Korean adults. Methods: This Phase 3b, multicenter, open-label study included 2 cohorts. In Cohort 1, participants with...
Background Transforming growth factor beta-1 (TGFβ 1) has been suggested to play a role in the development, or progression of hepatocellular carcinoma (HCC). Genotype and serum titer HCV also affect occurrence HCC chronic hepatitis C. In this study, we were evaluate effects genotype on expression TGFβ 1. We intended examine correlation between up-regulation 1 association with patients Methods studied 19 C 18 associated infection. was determined by line probe reverse hybridization assay...