A5100744568- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- HIV/AIDS drug development and treatment
- Drug-Induced Hepatotoxicity and Protection
- Health and Wellbeing Research
- Viral gastroenteritis research and epidemiology
- Nutrition, Health and Food Behavior
- Hemophilia Treatment and Research
- Gender Politics and Representation
- Inflammatory Myopathies and Dermatomyositis
- Stroke Rehabilitation and Recovery
- Healthcare and Venom Research
- Pharmacy and Medical Practices
- Eosinophilic Esophagitis
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Bone and Joint Diseases
- Muscle and Compartmental Disorders
- Cancer Mechanisms and Therapy
- Gastrointestinal Bleeding Diagnosis and Treatment
Chung-Ang University Hospital
2002-2025
Chung-Ang University
2013-2023
Soonchunhyang University
2013-2016
Chungnam National University
2016
Hanyang University
2016
Kyungpook National University
2016
Hallym University
2009-2016
Sungkyunkwan University
1998-2016
Yonsei University
2016
Ulsan College
2016
Table 1.Grading evidence and recommendations Evidence Notes High quality Further research is very unlikely to change our confidence in the estimate of effect A Moderate likely have an important impact on may B Low estimate.Any uncertain C Recommendation Strong Factors influencing strength recommendation included evidence, presumed patient-important outcomes, cost 1 Weak Variability preferences values, or more uncertainty.Recommendation made with less certainty, higher resource consumption 2
Abstract The treatment decisions for patients with hepatocellular carcinoma are determined by a wide range of factors, and there is significant difference between the recommendations widely used staging systems actual initial choices. Herein, we propose machine learning-based clinical decision support system suitable use in multi-center settings. We collected data from nine institutions South Korea training validation datasets. internal external datasets included 935 1750 patients,...
<h3>Background:</h3> Despite the initial absolute or relative contraindication of laparoscopic surgery during pregnancy, in last decade, appendectomy (LA) has been performed pregnant women. But few studies compare outcomes LA compared with open (OA). We investigated clinical to evaluate safety and efficacy OA <h3>Methods:</h3> recruited consecutive patients a diagnosis acute appendicitis who were undergoing between May 2007 August 2011 into study. <h3>Results:</h3> Sixty-one (22 39 OA)...
This study aimed to develop and validate a risk prediction model for the development of hepatocellular carcinoma (HCC) in treatment-naïve patients receiving oral antiviral treatment chronic hepatitis B (CHB).We investigated 2,061 Korean with CHB treated entecavir as an initial therapy. A score HCC was developed based on multivariable Cox regression single center (n=990) validated using time-dependent area under receiver operating characteristic curve (AUROC) three other centers (n=1,071)....
To compare immunization coverage and equity distribution of between 2001 2014 in Nepal.We used data from the Demographic Health Surveys carried out 2001, 2006 2011 together with Multiple Indicator Cluster Survey. We calculated proportion, mean percentage, children who had received bacille Calmette-Guérin (BCG) vaccine, three doses polio diphtheria-pertussis-tetanus (DPT) vaccine measles vaccine. measure inequities wealth quintiles, we slope index inequality (SII) relative (RII) for all...
Background and Aims In patients with chronic hepatitis B (CHB) infection, activation of toll‐like receptor 8 may induce antiviral immunity drive functional cure. Selgantolimod, a agonist, was evaluated in CHB who were virally suppressed on oral treatment or viremic not treatment. Approach Results this phase 1b study, randomized 4:1 to receive either selgantolimod placebo once weekly. Virally received 1.5 mg (for 2 weeks) 3 weeks 4 weeks). Viremic for weeks. The primary endpoint safety, as...
Virtual reality therapy (VRT) uses multimodal stimulation that includes visual, auditory, olfactory, and gustatory stimuli. The aim of this study was to assess the effectiveness VRT in treating subjects with alcohol dependence (AD) by evaluating changes brain metabolism.The protocol consisted three steps: relaxation, presentation a high-risk situation, an aversive situation. Twelve alcohol-dependent underwent 10 sessions VRT. were assessed 18F-fluorodeoxyglucose positron emission tomography...
<h3>Objective</h3> Foxp3<sup>+</sup>CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells (Tregs) control immune responses, but their role in acute viral hepatitis remains elusive. Herein, we investigated alteration the peripheral blood Treg population during A (AHA) and its implication immune-mediated liver injury. <h3>Design</h3> The study included 71 patients with AHA, mononuclear (PBMCs) were isolated. suppressive activity of was determined by assessing anti-CD3/CD28-stimulated...
RO7062931 is an N-acetylgalactosamine (GalNAc)-conjugated single-stranded locked nucleic acid oligonucleotide complementary to HBV RNA. GalNAc conjugation targets the liver through asialoglycoprotein receptor (ASGPR). This two-part phase 1 study evaluated safety, pharmacokinetics, and pharmacodynamics of in healthy volunteers patients with chronic hepatitis B (CHB) who were virologically suppressed.Part was a single ascending dose randomized receive (0.1-4.0 mg/kg), or placebo. Part 2...
Background/Aims Hepatocellular carcinoma (HCC), which is the third most common cancer in Korea, has a very poor prognosis. However, only few studies have performed comprehensive survival-related analysis all patients who were consecutively diagnosed and treated over given period of time. The aim this study was to determine 5-year survival rate its prognostic factors among HCC patients. Methods In total, 257 with between January 2000 December 2003 followed until death or 2008. We analyzed...
Sorafenib is recommended as a standard treatment for advanced hepatocellular carcinoma (HCC). The efficacy and safety of sorafenib first-line therapy in Korean patients with HCC were investigated.From 2007 to 2012, 86 (Barcelona Clinic Liver Cancer stage C) treated enrolled from five tertiary hospitals. Predictors overall survival (OS) progression-free (PFS) analyzed.The median age was 59.5 years, 71 (82.6%) males; 57 (66.3%) Child-Pugh class A. OS PFS 5.0 (range 4.0-5.9) 3.2 2.6-3.7)...
Background: Nonalcoholic steatohepatitis (NASH) is a hepatic manifestation of metabolic syndrome. We aimed to assess the relationship syndrome-associated NASH and insulin resistance (IR), define correlation chemicometabolic components with different degree liver histology in subjects. Study: Ninety-four subjects (mean age, 38±14 y; 77% male) were enrolled. IR was calculated using homeostasis model assessment (HOMA-IR). Clinical characteristics including accompanying risk compared those 52...
Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown association between and malignant tumors such as ovarian cancer, lung colorectal cancer. However, a chronic hepatitis B virus (HBV) infection associated hepatocellular carcinoma (HCC) very rarely reported. Here, we report rare case of coinciding HBV-associated HCC. A...
Background and Aims Clinical manifestations of hepatitis A virus (HAV) infection vary from mild to fulminant hepatic failure (FHF) in adults. We investigated the relationship between laboratory findings, including viral load, clinical outcomes patients with acute (AHA) evaluated predictive factors for severe (s-AH). Methods analyzed AHA 770 patients. Patients a prothrombin time (PT) less than 40% normal were classified as s-AH included 4 FHF, 11 renal failure, 3 prolonged jaundice (n = 128)....
Background The efficacy of adefovir dipivoxil (ADV) or entecavir (ETV) rescue monotherapy has not been directly compared in hepatitis B e antigen (HBeAg)- positive patients with lamivudine (3TC)-resistant chronic (CHB). We the ADV and ETV HBeAg-positive confirmed genotypic 3TC resistance. Methods A total 160 resistance underwent switch therapy (91 59 ETV). Parameters assessed included alanine aminotransferase (ALT) normalization, HBeAg serocon-version, undetectable serum virus (HBV) DNA by...
Hepatocellular carcinoma (HCC) is one of the major cancers with a high incidence and mortality in Korea. A Korean multidisciplinary collaborative committee consisting hepatologists, radiologists, epidemiologists family medicine doctors systematically reviewed clinical practice guidelines world literatures. The level evidence for each recommendation was assessed discussed to reach consensus. Meta-analysis also conducted evaluate grade five key questions. Several randomized controlled studies...
Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV CKD is not clear. This study investigated in a nationwide multicenter study. A total of 265,086 subjects who underwent health-check examinations 33 hospitals from January 2015 December were enrolled. surface antigen (HBsAg) positive cases (n = 10,048), age- gender-matched HBsAg negative controls 40,192) identified. was defined as...