A5101848157- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Liver Diseases and Immunity
- vaccines and immunoinformatics approaches
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Diagnosis and treatment of tuberculosis
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Tuberculosis Research and Epidemiology
- Chemokine receptors and signaling
- RNA Interference and Gene Delivery
- Cancer Treatment and Pharmacology
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Algal biology and biofuel production
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
Target (United States)
2021
Korea Advanced Institute of Science and Technology
2013-2020
<h3>Objective</h3> Foxp3<sup>+</sup>CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells (Tregs) control immune responses, but their role in acute viral hepatitis remains elusive. Herein, we investigated alteration the peripheral blood Treg population during A (AHA) and its implication immune-mediated liver injury. <h3>Design</h3> The study included 71 patients with AHA, mononuclear (PBMCs) were isolated. suppressive activity of was determined by assessing anti-CD3/CD28-stimulated...
Acute hepatitis A caused by virus (HAV) infection is accompanied severe liver injury in adult patients, and the associated with production of chemokines. Herein, we investigated mechanism how HAV induces CXCR3 CCR5 chemokines, such as CXCL10, CCL4 CCL5. The CCL5 was markedly increased (HM-175/18f) culture primary human hepatocytes HepG2 cells. In particular, CXCL10 produced HAV-infected cells, not neighboring uninfected Moreover, these chemokines were significantly sera acute patients....
Purpose: T cell-mediated immune responses, and particularly activation of polyfunctional cells that simultaneously produce multiple cytokines, are necessary for the control Myco bacterium tuberculosis.In present study, we examined if DNA immunization Mycobacte rium tuberculosis resuscitation-promoting factor B (RpfB) elicits cell responses in mice.Materials Methods: C57BL/6 mice were immunized intramuscularly three times, at 3-week intervals, with RpfB-expressing plasmid DNA.For comparison,...
Aim: The immune system may play an important role in the pathogenesis of cardiovascular disease. T cell-driven inflammation human hypertension and atherosclerosis has recently been revealed. In present study, we evaluated association between serum levels C-X-C chemokine receptor type 3 chemokines carotid intima media thickness (IMT) humans.Methods: One hundred sixty-four consecutive patients undergoing baseline 2-year follow-up IMT (110 men, 62.4±10.0 years) were enrolled. maximum (max-IMT)...
Growing concerns about unpredictable influenza pandemics require a broadly protective vaccine against diverse strains. One of the promising approaches was T cell‐based vaccine, but narrow breadth ‐cell immunity due to immunodominance hierarchy established by previous infection and efficacy only mild challenge condition are important hurdles overcome. To model in humans an experimental setting, influenza‐primed C 57 BL /6 mice were chosen boosted with mixture vaccinia recombinants,...
Ribavirin is an antiviral drug used in combination with pegylated interferon-α (IFN-α) for the treatment of hepatitis C virus (HCV) infection. Recently, ribavirin was reported to inhibit suppressive activity regulatory T (Treg) cells. In present study, we re-evaluated effect on Foxp3(+)CD4(+)CD25(+) Treg cells from normal donors. First, examined expression CTLA-4 and CD39, which are known play a role function We found that did not modulate CD39 also studied presence IFN-α; however, changed...
Since the coronavirus disease outbreak in 2019, several antibody therapeutics have been developed to treat severe acute respiratory syndrome 2 (SARS-CoV-2) infections. Antibody are effective neutralizing virus and reducing hospitalization patients with mild moderate These target spike protein of SARS-CoV-2; however, emerging mutations this reduce their efficiency. In study, we a universal SARS-CoV-2 antibody. We generated humanized monoclonal antibody, MG1141A, against receptor-binding...
During microbial infection, bystander CD8+ T cells that are not specific to infecting pathogens can be activated by cytokines, such as IL-15. However, the tissue-homing properties of bystander-activated have been elucidated. Here, we examined effects IL-15 on expression chemokine receptors and their migration. We found up-regulates CCR5 in memory absence TCR stimulation enhances CCR5-dependent migration vitro vivo. IL-15-induced up-regulation was abrogated concurrent stimulation, indicating...
Abstract FoxP3+ regulatory T cells (Tregs) are essential for maintaining self-tolerance and homeostasis in the immune system. Their role character already shown many disease model, however, still concealed acute viral hepatitis. In this study, we investigated alteration peripheral blood Treg population during hepatitis A (AHA) its implication immune-mediated liver injury. Using isolated mononuclear (PBMCs) of 62 AHA patients, decreased frequency attenuated function Tregs were observed; those...