A5100733403- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Fire effects on ecosystems
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Streptococcal Infections and Treatments
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 detection and testing
- Herpesvirus Infections and Treatments
- Congenital Heart Disease Studies
- Immune Response and Inflammation
- Antibiotic Resistance in Bacteria
Gyeongsang National University
2020-2024
Korea Disease Control and Prevention Agency
2018-2022
Sunchon National University
2022
Chungbuk National University
2013-2021
Institute of Life Sciences
2021
Korea Research Institute of Bioscience and Biotechnology
2011-2020
Ulsan College
2010-2020
University of Ulsan
2010-2020
Korea Center for Disease Control and Prevention
2018-2020
Hallym University
2020
Background. Although Middle East Respiratory Syndrome coronavirus (MERS-CoV) is characterized by a risk of nosocomial transmission, the detailed mode transmission and period virus shedding from infected patients are poorly understood. The aims this study were to investigate potential role environmental contamination MERS-CoV in healthcare settings define viable MERS patients.
Abstract Background In addition to seasonal influenza viruses recently circulating in humans, avian (AIVs) of H5N1, H5N6 and H7N9 subtypes have also emerged demonstrated human infection abilities with high mortality rates. Although viral infections are usually diagnosed using isolation serological/molecular analyses, the cost, accessibility, availability these methods may limit their utility various settings. The objective this study was develop optimized a multiplex detection system for...
The endemicity of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in Asia has led to the generation reassortant H5 strains with novel gene constellations. A newly emerged HPAI A(H5N8) virus caused poultry outbreaks Republic Korea 2014. Because emerging high-pathogenicity continue pose public health risks, it is imperative that their pathobiological properties be examined. Here, we characterized A/mallard duck/Korea/W452/2014 (MDk/W452(H5N8)), a representative virus, and evaluated...
Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number countries. Further, the level natural immunity induced by infection is not fully clear, nor it clear if primary protective against reinfection. To investigate potential association between serum antibody titres and SARS-CoV-2, ferrets with different levels NAb after were subjected to heterologous strain. All reinfected showed active virus replication upper respiratory gastro-intestinal tracts. However, high...
Abstract Few studies have used a longitudinal approach to describe the immune response SARS-CoV-2 infection. Here, we perform single-cell RNA sequencing of bronchoalveolar lavage fluid cells longitudinally obtained from SARS-CoV-2-infected ferrets. Landscape analysis lung microenvironment shows distinct changes in cell proportions and characteristics compared uninfected control, at 2 5 days post-infection (dpi). Macrophages are classified into 10 subpopulations with transcriptome among...
While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing manifestations patients different ages, three groups ferrets are infected with SARS-CoV-2. Although is isolated from all regardless age, (≥3 old) show viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration,...
Persistent Staphylococcus aureus bacteremia (SAB) that fails to respond appropriate antibiotic therapy is associated with poor outcomes. Comprehensive prospective studies on risk factors and outcomes of persistent are limited. We investigated encompassing clinical, pharmacokinetic, microbiologic, genotypic characteristics using a case-control study nested in cohort patients SAB at tertiary-care hospital from August 2008 through September 2010. compared the clinical characteristics,...
Dabie bandavirus (severe fever with thrombocytopenia syndrome virus [SFTSV]) induces an immunopathogenic disease a high fatality rate; however, the mechanisms underlying its clinical manifestations are largely unknown. In this study, we applied targeted proteomics and single-cell transcriptomics to examine differential immune landscape in SFTS patient blood. Serum immunoprofiling identified low-risk high-risk clusters of patients based on inflammatory cytokine levels, which corresponded...
Influenza A virus infections continue to pose a major threat humans and several animal species. Neuraminidase (NA) is one of the most promising targets for development drugs against influenza viruses because its critical role in viral life cycle. During course search NA inhibitors from edible natural sources, we found that ethyl acetate layer ethanol extracts Ecklonia cava showed extremely high NA-inhibitory activity (72.1% inhibition at 30 μg/mL). Bioactivity-guided fractionation yielded...
Neuraminidase inhibitors (NAIs) have been widely used to control influenza virus infection, but their increased use could promote the global emergence of resistant variants. Although various mutations associated with NAI resistance identified, amino acid substitutions that confer multidrug undiminished viral fitness remain poorly understood. We therefore screened a known mutation(s) currently approved NAIs oseltamivir, zanamivir, and peramivir by assessing recombinant viruses mutant...
MicroRNAs (miRNAs) are known to regulate various biological processes, including expression of cellular gene and virus-induced inflammation. Recently, studies have indicated that some miRNAs could influenza virus replication. Due differential sensitivities A strains different species (avian mammalian), variations in host responses may be observed. Therefore, we investigated compared the differences global miRNA mouse lungs infected with wild type low pathogenicity A/Aquatic...
A novel genotype of H5N6 influenza viruses was isolated from migratory birds in South Korea during November 2016. Domestic outbreaks this virus were associated with die-offs wild near reported poultry cases Chungbuk province, central Korea. Genetic analysis and animal studies demonstrated that the Korean are highly pathogenic avian (HPAI) these reassortants at least three different subtypes (H5N6, H4N2 H1N1).
To compare the clinical and laboratory features of IgG4-related disease (IgG4-RD) lymphocyte-variant hypereosinophilic syndrome (L-HES), two rare diseases that often present with lymphadenopathy, gastrointestinal symptoms, eosinophilia, elevated immunoglobulins/IgE.Comparative case series 31 patients IgG4-RD 13 L-HES.Peripheral blood eosinophilia was in eight compared to L-HES (median eosinophils 0.4 vs 7.0 giga/L, P=.001) 12 20 had increased serum IgE L-HES, P=.930. Twenty-seven 30 IgG4...
Highly pathogenic avian influenza (HPAI) A(H5N6) and A(H5N8) virus infections resulted in the culling of more than 37 million poultry Republic Korea during 2016/17 winter season. Here we characterize two representative viruses, A/Environment/Korea/W541/2016 [Em/W541(H5N6)] A/Common Teal/Korea/W555/2017 [CT/W555(H5N8)], evaluate their zoonotic potential various animal models. Both Em/W541(H5N6) CT /W555(H5N8) are novel reassortants derived from gene pools wild bird viruses present migratory...
In this study, twelve neuraminidase (NA) inhibitory compounds 1-12 were isolated from heartwood of Caesalpinia sappan on the basis their biological activities against three types viral NAs. Of homoisoflavonoids, sappanone A (2) showed most potent NAs with IC(50) values 0.7 µM [H1N1], 1.1 [H3N2], and 1.0 [H9N2], respectively, whereas saturated homoisoflavonoid (3) did not show significantly inhibition. This result revealed that α,β-unsaturated carbonyl group in A-ring was key requirements for...
We describe the genetic and microbiological characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates with agr dysfunction from a tertiary-care hospital in Korea. Of these, ST5-SCCmec type II-agr group II MRSA isolates, which are known to be prevalent hospital-acquired infections Korea, were most abundant, because clonal spread specific agr-defective lineage. This finding suggests that loss function may confer potential advantage setting. Clonal defective-agr...