A5087202678- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Microbial infections and disease research
- Congenital Anomalies and Fetal Surgery
- Vector-Borne Animal Diseases
- Animal Nutrition and Physiology
- Mycobacterium research and diagnosis
- Coccidia and coccidiosis research
- Rabies epidemiology and control
- Virology and Viral Diseases
- Toxin Mechanisms and Immunotoxins
- Hepatitis Viruses Studies and Epidemiology
- Veterinary Oncology Research
- T-cell and Retrovirus Studies
- Herpesvirus Infections and Treatments
- Helminth infection and control
- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Animal health and immunology
- Viral Infections and Vectors
- Wnt/β-catenin signaling in development and cancer
Chonnam National University
2012-2022
National Cancer Institute
2012
National Veterinary Research and Quarantine Service
2005-2008
Ministry of Agriculture, Food and Rural Affairs
2007
Although winter dysentery (WD), which is caused by the bovine coronavirus (BCoV) characterized sudden onset of diarrhea in many adult cattle a herd, pathogenesis WD-BCoV not completely understood. In this study, colostrum-deprived calves were experimentally infected with Korean strain and examined for viremia, enteric nasal virus shedding as well viral antigen expression virus-associated lesions small large intestines upper lower respiratory tract from 1 to 8 days after an oral infection....
Sapovirus, a member of the Caliciviridae family, is an important cause acute gastroenteritis in humans and pigs. Currently, porcine sapovirus (PSaV) Cowden strain remains only cultivable Sapovirus genus. While some caliciviruses are known to utilize carbohydrate receptors for entry infection, functional receptor unknown. To characterize PSaV, we undertook comprehensive series protein-ligand biochemical assays mock PSaV-infected cell culture and/or piglet intestinal tissue sections. PSaV...
The cellular PI3K/Akt and/or MEK/ERK signaling pathways mediate the entry process or endosomal acidification during infection of many viruses. However, their roles in early events group A rotaviruses (RVAs) have remained elusive. Here, we show that late-penetration (L-P) human DS-1 and bovine NCDV RVA strains stimulate these very infection. Inhibition both significantly reduced production viral progeny due to blockage virus particles late endosome, indicating neither two is involved...
The receptor(s) for porcine sapelovirus (PSV), which causes diarrhea, pneumonia, polioencephalomyelitis, and reproductive disorders in pigs, remains largely unknown. Given the precedent other picornaviruses use terminal sialic acids (SAs) as receptors, we examined role of SAs PSV binding infection. Using a variety approaches, including treating cells with carbohydrate-destroying chemical (NaIO4), mono- or oligosaccharides (N-acetylneuraminic acid, galactose, 6'-sialyllactose),...
Highly pathogenic avian influenza (HPAI) is an extremely infectious, systemic viral disease of birds that produces high mortality and morbidity. HPAI was diagnosed in the three dead magpies (Pica pica sericea) submitted to National Veterinary Research Quarantine Service. At necropsy, prominent lesions were multifocal or coalescing necrosis pancreas with enlargement livers spleens. Microscopically, there severely necrotizing pancreatitis lymphocytic meningoencephalitis. Influenza antigen also...
Porcine sapelovirus (PSV), a species of the genus Sapelovirus within family Picornaviridae, is associated with diarrhea, pneumonia, severe neurological disorders, and reproductive failure in pigs. However, structural features complete PSV genome remain largely unknown. To analyze genomes, full-length nucleotide sequences three Korean strains were determined analyzed using bioinformatic techniques comparison other known strains. The genomes ranged from 7,542 to 7,566 nucleotides excluding 3′...
Sapelovirus A (SV-A), formerly known as porcine sapelovirus a member of new genus , is to cause enteritis, pneumonia, polioencephalomyelitis and reproductive disorders in pigs. We have recently identified α2,3-linked sialic acid on GD1a ganglioside functional SV-A receptor rich the cells pigs chickens. However, role viral pathogenesis remains elusive. Here, we demonstrated that Korean strain could induce diarrhoea intestinal pathology piglets but not chicks. Moreover, this had mild...
Abstract Intestinal epithelial tight junctions (TJ) are a major barrier restricting the entry of various harmful factors including pathogens; however, they also represent an important portal for pathogens. Although rotavirus-induced early disruption TJ integrity and targeting proteins as coreceptors well-defined, precise molecular mechanisms involved remain unknown. In present study, infection polarized MDCK cells with species A rotavirus (RVA) strains human DS-1 bovine NCDV induced...
ABSTRACT Group A rotaviruses are a major cause of acute gastroenteritis in young children as well many domestic animals. The rotavirus genome is composed 11 segments double-stranded RNA and can undergo genetic reassortment during mixed infections, leading to progeny viruses with novel or atypical phenotypes. aim this study was determine if the bovine group strains KJ44 KJ75, isolated from clinically infected calves, share features obtained heterologous species. All genes sequences KJ75 were...
Summary Since the first rabies case was reported in a dog 1907, disease enzootic up to 1975 Korea. After steady decrease number of cases from 1976 1984, no for 8 years 1985 1992. Then, resurgence noted 1993, and continuous increase observed during following years. This report provides information on South Korea reemerging period 1993–2003. A total 364 five different animal species deaths human beings as result were reported. Cattle dogs accounted 46.4% 40.4% cases, respectively, raccoon...
Despite the impact of bovine group A rotaviruses (GARVs) as economically important and zoonotic pathogens, there is a scarcity data on cross-species pathogenicity extra-intestinal spread reassortant GARVs. During course characterizing genotypes all 11 genomic segments GARVs isolated from diarrheic calves in South Korea, unique G6P[7] GARV strain (KJ9-1) was isolated. The harbors five bovine-like gene (VP7: G6; VP6: I2; VP1: R2; VP3: M2; NSP2: N2, NSP4: E2), porcine-like (VP4: P[7]; NSP1: A1;...
A total of 804 goat sera were collected from 144 farms in five regions South Korea during a period between 2005 and 2006 screened for the antibodies viral pathogens ruminants. The individual seropositive rates each virus 13.7% (110/804) bovine herpesvirus-1 (BHV-1), 9.5% (76/804) parainfluenza type-3 (PI-3V), 5.5% (44/804) Akabane (AKAV), 13.3% (107/804) Aino (AINV), 2.0% (16/804) Chuzan (CHUV) 1.0% (8/804) coronavirus (BCoV). Compared with other areas, Chungcheong Province showed higher...