A5038877693- Ocular Surface and Contact Lens
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Glaucoma and retinal disorders
- Olfactory and Sensory Function Studies
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Mast cells and histamine
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Advancements in Transdermal Drug Delivery
- Ophthalmology and Visual Impairment Studies
- Anesthesia and Pain Management
- Respiratory viral infections research
- Drug-Induced Adverse Reactions
- Mobile Health and mHealth Applications
- Long-Term Effects of COVID-19
- Vestibular and auditory disorders
- Social Media in Health Education
- Circadian rhythm and melatonin
Juntendo University
2020-2024
Discontinuation of contact lens use is mainly caused by lens-associated dry eye. It crucial to delineate eye's multifaceted nature tailor treatment each patient's individual needs for future personalized medicine.This paper aims quantify and stratify subjective symptoms eye clarify its risk factors medicine using the smartphone app DryEyeRhythm (Juntendo University).This cross-sectional study included iPhone (Apple Inc) users in Japan who downloaded DryEyeRhythm. was used collect medical big...
Multidimensional integrative data analysis of digital phenotyping is crucial for elucidating the pathologies multifactorial and heterogeneous diseases, such as dry eye (DE). This crowdsourced cross-sectional study explored a novel smartphone-based strategy to stratify visualize heterogenous DE symptoms into distinct subgroups. were collected from 3,593 participants between November 2016 September 2019. Dimension reduction via Uniform Manifold Approximation Projection stratified seven...
The prevalence of hay fever, a multifactorial allergic disease, is increasing. Identifying individual characteristics and associated factors fever essential for predictive, preventive, personalized, participatory (P4) medicine. This study aimed to identify using an iPhone application AllerSearch.This large-scale mobile health-based cross-sectional was conducted between February 2018 May 2020. Individuals who downloaded AllerSearch in Japan provided comprehensive self-assessment (general...
Introduction The number of cataract surgeries, the most common ophthalmic surgery, is expected to increase due ageing populations. Dry eye disease (DED) a frequent side effect contributing lower postoperative patient satisfaction and suboptimal quality vision. It unclear which eye-drops commonly used in these patients should be recommended for DED treatment. This study aims compare efficacy topical administration diquafosol sodium 3% vs hyaluronic acid 0.1% with after surgery. Methods...
Multidisciplinary efforts to prospectively collect and analyze symptoms of hay fever are limited. We aimed identify the characteristics nasal ocular fever, using AllerSearch smartphone application.This mobile health-based prospective observational study application was conducted between February 1, 2018, May 2020. Individuals who downloaded from Japan provided comprehensive self-assessments (including 17 items related quality life [QoL]-related items) were included. The risk factors for...
Dry eye disease (DED) is one of the most common ocular surface diseases. Numerous patients with DED remain undiagnosed and inadequately treated, experiencing various subjective symptoms a decrease in quality life work productivity. A mobile health smartphone app, namely, DEA01, has been developed as noninvasive, noncontact, remote screening device, context an ongoing paradigm shift care system, to facilitate diagnosis DED.This study aimed evaluate capabilities DEA01 app diagnosis.In this...
Abstract Background Hay fever is a common allergic disease, with an estimated worldwide prevalence of 14.4% and variety symptoms. This study assessed the minimal clinically important difference (MCID) nasal symptom score (NSS), non‐nasal (NNSS), total symptoms (TSS) for app‐based hay‐fever monitoring. Methods MCIDs were calculated based on data from previous large‐scale, crowdsourced, cross‐sectional using AllerSearch, in‐house smartphone application. determined anchor‐based...
Abstract Various symptoms of the dry eye disease (DED) interfere with quality life and reduce work productivity. Therefore, screening, prevention, treatment DED are important. We aimed to investigate potential diagnostic ability maximum blink interval (MBI) (the length time participants could keep their eyes open) disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 113 without DED) recruited between September 2017 December 2019. Discriminant validity...
The purpose of this study was to compare central corneal thickness, thinnest and the point cornea between Pentacam anterior segment optical coherence tomography (ASOCT) in patients with dry eye disease (DED). This cross-sectional included 195 participants November 2015–June 2017. DED diagnosed using Asia Dry Eye Society criteria further divided into mild severe based on kerato-conjunctival vital staining. Central measured by ASOCT were compared, Pearson’s correlation coefficients estimated....
Abstract Corneal allograft survival is mediated by the variety of immunological reactions and wound healing process. Our aim was to explore effects topical administration ripasudil, a selective Rho-associated coiled-coil protein kinase inhibitor, on corneal survival. Ripasudil administered mice thrice day after allogeneic transplantation. graft survival, opacity, neovascularization, re-epithelization, immune cell infiltration, mRNA levels angiogenic pro-inflammatory factors in grafted cornea...
To investigate the effects of ex vivo-induced bone marrow myeloid-derived suppressor cells (BM-MDSCs) on allogeneic immune responses in corneal transplantation.Bone from C57BL/6J (B6) mice were cultured with IL-6 and GM-CSF for four days. The vivo induction BM-MDSCs was assessed using flow cytometry, inducible nitric oxide synthase (iNOS) mRNA expression reverse transcription-quantitative polymerase chain reaction, (NO) production stimulation. T-cell proliferation regulatory (Treg) expansion...
Abstract Background Hay fever (HF) presents with various symptoms, including allergic conjunctivitis and rhinitis, requires cross‐organ treatment. This study assessed the impact of coronavirus disease 2019 (COVID‐19) pandemic on HF treatment trends. Methods retrospective cohort utilized data from JMDC database collected between January 2018 May 2021. Patients were identified based relevant International Classification Diseases 10th Revision diagnosis codes prescription HF‐related...