A5059705418- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Bone health and osteoporosis research
- Pain Mechanisms and Treatments
- Bone Metabolism and Diseases
- Musculoskeletal pain and rehabilitation
- COVID-19 Clinical Research Studies
- Bone health and treatments
- Management of metastatic bone disease
- Orthopaedic implants and arthroplasty
- COVID-19 and healthcare impacts
- Botulinum Toxin and Related Neurological Disorders
- Redox biology and oxidative stress
- IL-33, ST2, and ILC Pathways
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical Imaging and Analysis
- Sulfur Compounds in Biology
- Psoriasis: Treatment and Pathogenesis
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Dermatology and Skin Diseases
- Long-Term Effects of COVID-19
- Glutathione Transferases and Polymorphisms
- Phagocytosis and Immune Regulation
- Immunodeficiency and Autoimmune Disorders
Chiba University
2020-2024
Teikyo University Chiba Medical Center
2021-2022
The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome 2 (SARS-CoV-2) infection–triggered immune dysregulation and aberrant activation platelets. We combined histological analyses using field emission scanning electron microscopy energy-dispersive X-ray spectroscopy the lungs from autopsy samples single-cell RNA sequencing peripheral blood mononuclear cells to investigate pathogenesis...
CD4+ memory T cells are central to long-lasting protective immunity and involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for generation cells, mechanisms controlling redox metabolism cell formation remain unclear. We found that reactive oxygen species (ROS) changed dramatically helper-2 (Th2) during contraction phase process formation. Thioredoxin-interacting protein (Txnip), a regulator oxidoreductase, regulated apoptosis by...
Abstract This study aimed to perform a comparative analysis of postoperative results between lumbar degenerative spondylolisthesis (LDS) treated with oblique lateral interbody fusion (OLIF) and transforaminal (TLIF) from the Chiba spine surgery registry database. Sixty-five patients who underwent single-level OLIF (O group) for LDS ≥ 3 years’ follow-up were retrospectively reviewed. The control group comprised 78 TLIF (T group). analyzed variables included global alignment, radiological...
Abstract Purpose Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for severity. We therefore investigated mechanism underlying COVID-19 exacerbation induced by IFNs. Methods evaluated plasma from 123 measure performed single-cell RNA sequencing (scRNA-seq) peripheral blood mononuclear cells and conducted epitope mapping auto-abs....
This study investigated the effect of romosozumab on bone union in a rat posterolateral lumbar fixation model. Posterolateral was performed 8-week-old male Sprague Dawley rats (n = 20). For grafting, autogenous (40 mg) harvested from spinous processes 10th thoracic vertebra until 2nd and implanted between intervertebral joints transverse 4th 5th vertebrae both sides. Rats were matched by body weight equally divided into two groups: R group (Evenity®, 25 mg/kg) control (C) (saline)....
Uncontrolled type 2 immunity by helper T (Th2) cells causes intractable allergic diseases; however, whether the interaction of CD4 + shapes pathophysiology diseases remains unclear. We identified a subset Th2 that produced serine proteases granzyme A and B early in differentiation. Granzymes cleave protease-activated receptor (Par)-1 induce phosphorylation p38 mitogen-activated protein kinase (MAPK), resulting enhanced production IL-5 IL-13 both mouse human cells. Ubiquitin-specific protease...
Diffuse idiopathic skeletal hyperostosis (DISH)-related vertebral fractures essentially require operative treatment due to severe fracture site instability and high potential risk of posttraumatic neurological deficit. However, the optimal surgical procedure remains unclear. The purpose this study was assess efficacy posterior spinal fixation with penetrating endplate screws (PESs) for DISH-related thoracolumbar fractures.
Diclofenac etalhyaluronate (DF-HA) is a recently developed analgesic conjugate of diclofenac and hyaluronic acid that has anti-inflammatory effects on acute arthritis. In this study, we investigated its effect osteoarthritis, using rat model monoiodoacetate (MIA).We injected MIA into the right knees eight 6-weeks-old male Sprague-Dawley rats. Four weeks later, rats were randomly with DF-HA or vehicle knee. Seven after injection, fluorogold (FG) sterile saline all We assessed hyperalgesia...
Spinal fixation surgery has been increasingly performed in patients with osteoporosis. Romosozumab, a drug that was introduced Japan recently, is known to possibly promote bone healing. However, few studies have reported the therapeutic effects of romosozumab clinical practice Japan. Therefore, here, we investigated dosage on fusion promotion using an ovariectomized rat spinal model. Eight-week-old female Sprague-Dawley rats were matched by body weight and divided into three groups: 1.0 (R)...
Abstract This study examined the factors that inhibit therapeutic effects of cognitive behavioral therapy (CBT) and clarify adaptation judgment criteria CBT. We included patients with chronic low back pain allocated them to (with visual analog scale [VAS] improvement) or non-adaptation group (without VAS improvement). The were analyzed using various psychological tests. CBT improved depressive symptoms catastrophic thinking; however, they not correlated did directly affect improvement....
In this multicenter retrospective observational study, we examined the early effects of romosozumab in patients with severe osteoporosis terms time-course changes bone metabolism marker, improvement density, and adverse effects.Patients were included. We investigated progress TRACP 5b P1NP before 1-2 months after administration romosozumab. also density lumbar spine, femoral neck, entire femur, measured by DXA method, 5-7 romosozumab.A total 70 (7 males 63 females, age 75.0±3.6 years)...
Mirogabalin should be equivalent to pregabalin, but with fewer incidences of adverse drug reactions (ADRs). To verify these benefits in actual clinical trials, our study investigated the frequency ADRs and mirogabalin's analgesic effects during treatment peripheral neuropathic pain.This included 74 patients lower limb pain. We surveyed patient reports follow-up period as primary endpoint examined visual analog scale (VAS) reported for pain secondary (before administration, two four weeks...
Romosozumab reportedly increases bone density in patients with severe osteoporosis; however, data on its clinical effects are limited. We conducted a multicenter retrospective survey to study the density-increasing of romosozumab and blood test-based predictive factors osteoporosis, examining practice. This was observational study. The subjects were osteoporosis who treated at participating facilities. increase assessed by comparing changes (as percentage) lumbar spine, femoral neck, total...
Prospective cohort study (open-label, single-arm, and non-blinded).This aims to determine the effects of systemic administration tocilizumab, an anti-interleukin-6 (IL-6) receptor antibody on refractory low back pain leg symptoms.IL-6 overexpression is associated with neuropathic pathogenesis, which potentially followed by chronic pain, including numbness. This finding suggest that inhibition IL-6 at site or in transmission pathway could provide novel therapeutic targets for pain.This...
With the advancement of cancer treatment and minimally invasive surgery, indications for surgery metastatic spinal tumors are expanding. Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory disease characterized by calcification ossification ligaments entheses. In Japan, prevalence DISH increasing with its superaging society. The purpose this article to report case applying novel screw technique pathological fracture in patient metastasis. An 80-year-old man metastasis...
Abstract In this study, we investigated the effect of romosozumab on bone strength at fusion site in rats that underwent posterolateral lumbar fusion. For grafting, autogenous was harvested from spinous process and grafted between intervertebral joint transverse processes 4th, 5th, 6th vertebra bilaterally along with 40 mg demineralized matrix. Rats were matched by body weight divided equally into R (romosozumab, 25 mg/kg) C (control, saline) groups. Subcutaneous injections administered...