A5013578408- Spine and Intervertebral Disc Pathology
- Periodontal Regeneration and Treatments
- Platelet Disorders and Treatments
- Pain Mechanisms and Treatments
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Hemostasis and retained surgical items
- Inflammatory mediators and NSAID effects
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal pain and rehabilitation
- Management of metastatic bone disease
- Reconstructive Surgery and Microvascular Techniques
- Proteoglycans and glycosaminoglycans research
- Vascular Malformations and Hemangiomas
- Dental Implant Techniques and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Pharmacological Effects of Natural Compounds
Chiba University
2018-2024
This study aimed to evaluate the effects of romosozumab, a humanized monoclonal antibody, on bone healing and mechanical strength in rat posterolateral lumbar fusion (PLF) model. The primary objective was determine its potential promoting union enhancing structural integrity graft sites, addressing challenges such as pseudarthrosis hardware failure spinal surgeries. These complications are particularly common osteoporotic patients, where compromised quality reduced capacity significantly...
This study investigated the effect of romosozumab on bone union in a rat posterolateral lumbar fixation model. Posterolateral was performed 8-week-old male Sprague Dawley rats (n = 20). For grafting, autogenous (40 mg) harvested from spinous processes 10th thoracic vertebra until 2nd and implanted between intervertebral joints transverse 4th 5th vertebrae both sides. Rats were matched by body weight equally divided into two groups: R group (Evenity®, 25 mg/kg) control (C) (saline)....
Diclofenac etalhyaluronate (DF-HA) is a recently developed analgesic conjugate of diclofenac and hyaluronic acid that has anti-inflammatory effects on acute arthritis. In this study, we investigated its effect osteoarthritis, using rat model monoiodoacetate (MIA).We injected MIA into the right knees eight 6-weeks-old male Sprague-Dawley rats. Four weeks later, rats were randomly with DF-HA or vehicle knee. Seven after injection, fluorogold (FG) sterile saline all We assessed hyperalgesia...
Spinal fixation surgery has been increasingly performed in patients with osteoporosis. Romosozumab, a drug that was introduced Japan recently, is known to possibly promote bone healing. However, few studies have reported the therapeutic effects of romosozumab clinical practice Japan. Therefore, here, we investigated dosage on fusion promotion using an ovariectomized rat spinal model. Eight-week-old female Sprague-Dawley rats were matched by body weight and divided into three groups: 1.0 (R)...
Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell (iPSC)-derived megakaryocytes and (iMPs) are capable of providing a stable supply, holding promise as materials for novel platelet concentrate-based therapies. In this context, we evaluated the effect iMPs on...
Platelet-rich plasma (PRP) promotes bone union through osteoinduction. We investigated whether adding demineralized matrix (DBM), derived naturally from biomaterial and with various growth factors, for osteoconductivity marrow fluid osteogenesis results in different unions. Eight-week-old male Sprague-Dawley rats were divided into four groups of five based on transplantation material: sham control (C group); DBM alone (D + PRP (DP (DPB group). After posterolateral fusion at L3-5,...
Abstract Co‐administration of mirogabalin besylate and nonsteroidal anti‐inflammatory drugs is effective for neuropathic pain; however, mechanism its action remains unknown. We aimed to evaluate the this synergistic effect concomitant administration pain using chronic constriction injury model rats. Fifty male Wister rats 7‐week‐old were used. Right sciatic nerve ligation was performed in 40 they sub‐divided into four groups: vehicle, mirogabalin, diclofenac sodium co‐administration them....
<title>Abstract</title> Background Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell (iPSC)-derived megakaryocytes and (iMPs) are capable of providing a stable supply, holding promise as materials for novel platelet concentrate-based therapies. In this...
Diclofenac etalhyaluronate (DF-HA) sustained diclofenac release with the effects of hyaluronic acid (HA), offering long-term analgesia in osteoarthritis. In this study, DF-HA on pain improvement and osteoarthritis were evaluated a rat knee monoiodoacetate-induced model compared to HA. Eight rats per group had been injected monoiodoacetate (2.0 mg) or saline right for 4 weeks either (1.25 mg/kg; 0.5 mg), HA (0.5 vehicle which was substrate without (50 μL), followed weeks. Mechanical plantar...
Thus far, few reports have described the time series histological variations in injured paravertebral muscle tissues for long durations, considering type of pain. The purpose this study is to evaluate changes muscles and dominant nerves pain.We used 59 eight-week-old male Sprague-Dawley rats. A 115-g weight was dropped from a height 1 m on right muscle. Fluoro-Gold (FG), sensory nerve tracer, injected into Hematoxylin eosin (HE) staining growth factor (NGF) immunostaining were performed...
Abstract In this study, we investigated the effect of romosozumab on bone strength at fusion site in rats that underwent posterolateral lumbar fusion. For grafting, autogenous was harvested from spinous process and grafted between intervertebral joint transverse processes 4th, 5th, 6th vertebra bilaterally along with 40 mg demineralized matrix. Rats were matched by body weight divided equally into R (romosozumab, 25 mg/kg) C (control, saline) groups. Subcutaneous injections administered...