A5083529685- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Anesthesia and Pain Management
- Peripheral Nerve Disorders
- Structural Engineering and Vibration Analysis
- Gastrointestinal disorders and treatments
- Cancer-related Molecular Pathways
- Advanced Glycation End Products research
- Vibration and Dynamic Analysis
- Pain Mechanisms and Treatments
- Freezing and Crystallization Processes
- Medical Imaging and Analysis
- Blood properties and coagulation
- Structural Health Monitoring Techniques
- Skin and Cellular Biology Research
- Engineering Structural Analysis Methods
- Medical Imaging Techniques and Applications
- Dental Anxiety and Anesthesia Techniques
- Adenosine and Purinergic Signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Electric Power System Optimization
- Bone Metabolism and Diseases
- Cervical and Thoracic Myelopathy
Chiba University
1991-2024
University of Tsukuba
2014-2024
Teikyo University Chiba Medical Center
2021-2024
Kitasato University
2014-2024
The University of Tokyo
1999-2024
Saitama Red Cross Hospital
2024
Yamagata University
2021-2022
Showa University
2012-2017
National Center For Child Health and Development
2016
Akita University
2006-2013
Objective: In recent years, there has been an increase in research on the therapeutic effects of exergaming, but have few studies these types interventions for chronic low back pain. this study, we hypothesized that Nintendo Ring Fit Adventure (RFA) exergame would be effective patients with pain, and conducted a randomized prospective longitudinal study. Materials Methods: Patients pain were included Twenty randomly selected (9 males 11 females, mean age 49.3 years) RFA group, exergaming was...
Joubert syndrome (JS) is rare recessive disorders characterized by the combination of hypoplasia/aplasia cerebellar vermis, thickened and elongated superior peduncles, a deep interpeduncular fossa which defined neuroimaging termed 'molar tooth sign'. JS genetically highly heterogeneous, with at least 29 disease genes being involved. To further understand genetic causes JS, we performed whole-exome sequencing in 24 newly recruited families. Together six previously reported families,...
Heavy ion therapy has two definite advantages: good dose localization and higher biological effect. Range calculation of the heavy ions is an important factor in treatment planning. X-ray CT numbers are used to estimate range by looking up values a conversion table which relates empirically photon attenuation tissues particle stopping power; this one source uncertainty Use positron emitting radioactive beams along with emission tomograph or camera gives information may be as means checking...
Abstract This study aimed to perform a comparative analysis of postoperative results between lumbar degenerative spondylolisthesis (LDS) treated with oblique lateral interbody fusion (OLIF) and transforaminal (TLIF) from the Chiba spine surgery registry database. Sixty-five patients who underwent single-level OLIF (O group) for LDS ≥ 3 years’ follow-up were retrospectively reviewed. The control group comprised 78 TLIF (T group). analyzed variables included global alignment, radiological...
We compared the clinical effects of Neurotropin, limaprost alfadex, and a combination both drugs for lumbar spinal stenosis (LSS) with low back pain (LBP).We conducted multicenter, randomized, active-controlled, open-label trial from March 2021 to May 2022. Participants were patients diagnosed LSS by MRI randomly assigned three groups: Neurotropin/limaprost (NL group), Neurotropin (N group (L group). received administered orally 12 weeks, each examination observation was performed before any...
Abstract Background Lumbar spinal disease causes disabilities in performing daily activities. Operative treatments are aimed at pain relief and rapid return to routine activity. Patient-based outcome measures used evaluate pathologies therapeutic effects associated with lumbar disease. Nevertheless, it remains unknown as how much such treatment improves activity levels. The purpose of the current study was measure changes levels before after surgery using a wearable tracker analyze...
Monitoring of a 720 m span suspension bridge which is located at windy and seismically active area in northern part Japan, opened 1998 introduced. The purpose the monitoring to understand actual dynamic behavior loading conditions, develop health scheme using ambient vibration measurement readily available under service conditions. Data processing based on Ibrahim's time domain method constructed for identification natural frequencies, mode shapes modal damping ratios. Because input force...
Research Article| April 15, 2015 A Single Bit Matters: Coherent Noise of Seismic Data Loggers Ryota Takagi; Takagi aEarthquake Institute, University Tokyo, 1‐1 Yayoi 1, Bunkyo‐ku, Tokyo 113‐0032, Japanyaoki@eri.u-tokyo.ac.jp Search for other works by this author on: GSW Google Scholar Kiwamu Nishida; Nishida Yosuke Aoki; Aoki Takuto Maeda; Maeda Komei Masuda; Masuda Minoru Takeo; Takeo Kazushige Obara; Obara Katsuhiko Shiomi; Shiomi bNational Institute Earth Science and Disaster Prevention,...
Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by cartilage erosion, structural changes, and inflammation. Synovial fibroblasts play crucial role in OA pathophysiology, with abnormal fibroblastic cells contributing significantly to pathology. Fibrocytes, expressing markers of both hematopoietic stromal cells, are implicated inflammation fibrosis, yet their marker remain unclear. ENTPD1, an ectonucleotidase involved purinergic signaling expressed specific...
Forced and ambient dynamic tests of the Hakucho Bridge were carried out to study characteristics this suspension bridge. Dense-array measurement was employed in order capture not only natural frequencies damping, but also mode shapes The obtained from forced vibration agreed well with those calculated by a three-dimensional finite element model. A new method that combines random decrement Ibrahim time domain is proposed systematically identify frequencies, shapes. This successfully applied...
A practical route to quinoline from anilines through acid-mediated cyclization of 3-(N-aryl-N-sulfonylamino)propionaldehydes has been developed.Treatment the products, dihydroquinoline intermediates with KOH in DMSO leads substituted quinolines.
Abstract AGEs are permanently modified macromolecule derivatives that form through nonenzymatic glycation of amino groups proteins. Glycer-AGEs highly toxic and play an important role in the pathogenesis chronic inflammatory diseases. However, contribution glycer-AGEs to uveitis is unclear. In this study, we measured serum levels 100 patients with endogenous (22 HLA-B27-associated uveitis, 20 VKH disease, 14 Behçet's 44 sarcoidosis) 33 healthy volunteers. We then examined effect AGE...
Wearable accelerometers can be used to evaluate waking and sleeping movements. Although a correlation between accelerometer data captured at the wrist waist has been reported, it not evaluated in patients with low back pain. Therefore, this study aimed correlations movement measured waist, using wearable accelerometers, pain.Twenty chronic pain 20 healthy volunteers were enrolled. Two identical simultaneously worn by each participant, one on nondominant other for 1 week. We compared mean...
Abstract Laparoscopic cholecystectomy has become the gold standard for treatment of cholelithiasis, and many reports single‐incision laparoscopic have been published in past few years. Situs inversus totalis is a very rare condition, but variant anatomy should not preclude minimally invasive approach to surgery. We report case successful single‐port patient with situs totalis, describe technical advantages, review literature.
Introduction . Spinal scoliosis and kyphosis in elderly people sometimes cause severe low back pain. Surgical methods such as osteotomy are useful for correcting the deformity. However, complications during after surgery associated with procedure. In particular, it is difficult to manage deformity correction patients Parkinson's disease. Here, we present two cases of combined anterior posterior adult due Case Presentation Two 70-year-old women had spinal They pain, conservative treatment was...
Murine double minute homolog 2 (MDM2) is an oncoprotein that induces p53 degradation via ubiquitin‑ligase activity. MDM4 cooperates with MDM2‑mediated degradation, directly inhibiting transcription by binding to its transactivation domain. Our previous study reported the simultaneous inhibition of MDM2 and using nutlin‑3 (an inhibitor MDM2‑p53 interaction) chimeric small interfering RNA DNA‑substituted seed arms (named chiMDM2 chiMDM4) more potently activated than or alone synergistically...
Introduction: There are several reports about invasive muscle injury during posterior spinal surgery. However, few have evaluated the association between clinical symptoms and changes in physical properties of psoas major after oblique lateral interbody fusion (OLIF). Therefore, current study aimed to investigate relationship before OLIF.
Abstract This study examined the factors that inhibit therapeutic effects of cognitive behavioral therapy (CBT) and clarify adaptation judgment criteria CBT. We included patients with chronic low back pain allocated them to (with visual analog scale [VAS] improvement) or non-adaptation group (without VAS improvement). The were analyzed using various psychological tests. CBT improved depressive symptoms catastrophic thinking; however, they not correlated did directly affect improvement....
In this multicenter retrospective observational study, we examined the early effects of romosozumab in patients with severe osteoporosis terms time-course changes bone metabolism marker, improvement density, and adverse effects.Patients were included. We investigated progress TRACP 5b P1NP before 1-2 months after administration romosozumab. also density lumbar spine, femoral neck, entire femur, measured by DXA method, 5-7 romosozumab.A total 70 (7 males 63 females, age 75.0±3.6 years)...
Although most patients who undergo transforaminal lumbar interbody fusion (TLIF) show favorable surgical results, some still have unfavorable results for various reasons. This study aimed to investigate the influence of differences in lordosis (LL) between standing and supine positions (DiLL: LL-standing LL) on minimum 5-year outcomes after short-segment TLIF. Ninety-one with degenerative disease underwent TLIF (1-2 levels) were categorized based preoperative LL as DiLL (+) (-). Comparison...