A5101704369- Advanced MRI Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Advanced Neuroimaging Techniques and Applications
- Peripheral Nerve Disorders
- Airway Management and Intubation Techniques
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Anesthesia and Sedative Agents
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Spinal Fractures and Fixation Techniques
- Radiation Dose and Imaging
- Anesthesia and Pain Management
- Esophageal Cancer Research and Treatment
- Fluoride Effects and Removal
- Coastal and Marine Dynamics
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Gastrointestinal disorders and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Teikyo University Chiba Medical Center
2017-2025
Yamagata University
2020-2024
Tsukuba International University
2024
Kanazawa University
2003-2024
Chiba University
2021
Chiba University Hospital
2021
Kyushu Rosai Hospital
2015-2018
Tokushima University Hospital
2018
Prefectural University of Hiroshima
2015
Ministry of Economy, Trade and Industry
2015
A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration two drug-likeness metrics, ligand efficiency (LE) and fraction sp(3) carbon atoms (Fsp(3)), significant improvement metabolic stability as well reduction CYP inhibition observed, which finally led to discovery selective orally efficacious inhibitor 3z.
Abstract Purpose The diagnosis of adolescent lumbar spondylolysis typically requires computed tomography (CT) imaging; however, concerns regarding medical radiation exposure have emerged. With recent advancements in magnetic resonance imaging (MRI), it has become possible to acquire CT-like images using an MR bone approach. This study aimed investigate whether can be utilised as a substitute for CT evaluating the fracture line patients with spondylolysis. Methods We included 24 (28 levels)...
The effects of mild hypocapnia (PaCO2 22 mm Hg) and hypercapnia 59 on the splanchnic circulation hepatic function were studied in six pentobarbital anesthetized, laparotomized, mechanically ventilated beagles. Tidal volume respiratory frequency held constant throughout measurements. Hepatic artery blood flow (HABF) portal vein (PVBF) measured by electromagnetic flowmeters. was assessed indocyanine green (ICG) elimination kinetic analysis after intravenous injection dye. Hypocapnia caused a...
The effects of mild hypocapnia (Paco2 22 mm Hg) and hypercapnia 59 on the splanchnic circulation hepatic function were studied in six pentobarbital anesthetized, laparotomized, mechanically ventilated beagles. Tidal volume respiratory frequency held constant throughout measurements. Hepatic artery blood flow (HABF) portal vein (PVBF) measured by electromagnetic flowmeters. was assessed indocyanine green (ICG) elimination kinetic analysis after intravenous injection dye. Hypocapnia caused a...
Study Design. An in vivo model to study the effect of an injectable hyaluronic acid (HA) hydrogel following puncture-induced lumbar disc injury rabbits. Objectives. The aim this was determine efficacy HA maintain height and tissue hydration, promote structural repair, attenuate inflammation innervation discs. Summary Background Data. Previously, we have demonstrated that alleviated inflammation, innervation, pain repair. Nevertheless, a weight-bearing animal not performed. Methods. We...
Medications to treat hyperglycemia and hyperinsulinemia are expected inhibit the accumulation of advanced glycation end-products in diabetic kidney improve renal function by inhibiting oxidative reactions. In this study, we examined effect pioglitazone, an insulin sensitizer, on nephropathy. Feed containing pioglitazone at 0.01 or 0.02% was given Zucker-fatty rats for 27 weeks. Pioglitazone reduced plasma glucose, insulin, blood HbAlc levels. It also decreased total cholesterol,...
Obesity affects the gut microbiome, which in turn increases risk for colorectal cancer. Several studies have shown mechanisms by some bacteria may influence development of cancer; however, microbiome characteristics obese patients with cancer remain unclear. Therefore, this study evaluated their profile and its relationship metabolic markers.The assessed fecal samples from 36 consecutive 38 controls without To identify microbiotic variations between controls, as well nonobese individuals,...
siRNA-induced gene silencing in the salivary gland using microbubble-enhanced sonoporation was used to develop an vivo knockdown technique.siRNA targeting rat glyceraldehyde-3-phosphate dehydrogenas (GAPDH) mixed with echo-enhanced microbubbles and reverse-injected into parotid glands transdermal ultrasound. To compare direct ultrasound efficiencies, incision made on lateral neck expose for application. The efficiency of suppression determined quantitative reverse transcription-polymerase...
We studied the viability of high-performance liquid chromatography and mass spectrometry (LC/MS) as a selective sensitive analytical method for measuring blood concentrations local anesthetic ropivacaine. Ropivacaine was effectively separated using reverse-phase column monitored at 275 m/z ion. The LC/MS allowed measurement ropivacaine lower than 75 ng/mL. standard curve linear in range < 1.5 μg/mL. Recovery plasma samples over 90% after precipitation protein with trichloroacetic acid....
Objective Although magnetic resonance imaging (MRI) is the gold standard for evaluating abnormal myocardial fibrosis and extracellular volume (ECV) of left ventricular myocardium (LVM), a similar evaluation has recently become possible using computed tomography (CT). In this study, we investigated diagnostic accuracy new 256-row multidetector CT with low tube-voltage single energy scan deep-learning-image reconstruction (DLIR) in detecting late enhancement (LE) LVM. Methods We evaluated...
Cells of the osteoblastic cell line MC3T3-E1 were shown to contain at least three phosphatidylinositol-specific phospholipase C (PI-PLC) isoenzymes (PLC-beta, PLC-gamma and PLC-delta) by Western blotting analysis with various anti-PLC antibodies. Stimulation inositol phosphate production in cells bradykinin (BK) occurred via a GTP-binding protein. Inositol formation on stimulation BK was not affected pretreatment pertussis toxin, whereas it potentiated cholera toxin pretreatment. Elevation...
To assess the usefulness of linked color imaging (LCI), a recently developed image-enhanced endoscopy technique, in endoscopic diagnosis eosinophilic esophagitis (EoE).Thirty white light images (WLIs) and 30 WLI+LCI collected from patients with without EoE were randomly blindly reviewed by 10 endoscopists, including four experts (Exs) six non-Exs. Edema, ring, exudate furrows, strictures rated on adjusted reference score; was assessed. Using kappa value, inter- intra-observer agreements...
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.
Stimulation of Ca2+ (and Mn2+) entry in salivary epithelial cells by carbachol, or thapsigargin, is mediated an, as yet, unknown mechanism that dependent on the depletion from intracellular stores. This study assesses possible role protein phosphorylation regulation rat parotid gland acinar cells. Treatment with phosphatase inhibitors okadaic acid, calyculin A, and pervanadate induced a dose-dependent inhibition carbachol thapsigargin stimulation Mn2+ entry. All three decreased internal...
In blind source separation, convergence and separation performances are highly dependent on a relation between probability density functions (pdf) of signal sources nonlinear used in updating coefficients block. This was analyzed based kurtosis /spl kappa//sub 4/. It suggested that tanh y y/sup 3/, where is the output, useful for super-Gaussian (/spl 4/>0) sub-Gaussian 4/<0), respectively. this paper, an adaptive function proposed. has form f(y)=a y+(1-a)y/sup 3//4, controlled by output...
In typical kinase inhibitor programs, a hinge binder showing best potency with preferential specificity is initially selected, followed by fine-tuning of the accompanying substituents on its core module. A shortcoming this approach that exclusive focus single chemotype can endanger all analogues in series if critical revealed. Thus, an early evaluation structure-activity relationships (SARs) mitigate unforeseen outcomes within multiple compounds, although there have been very few examples to...