A5044021300- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Smoking Behavior and Cessation
- Cell Adhesion Molecules Research
- Cardiomyopathy and Myosin Studies
- Kawasaki Disease and Coronary Complications
- T-cell and B-cell Immunology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Takotsubo Cardiomyopathy and Associated Phenomena
- Immune Cell Function and Interaction
- Dupuytren's Contracture and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
Chiba University
2021-2025
Chiba University Hospital
2023-2024
Juntendo University Urayasu Hospital
2022
Minami Wakayama Medical Center
2022
National Hospital Organization
2022
Akebono (Japan)
2021
Suwa Red Cross Hospital
2017
Hebei Rehabilitation Hospital
2008
Shibuya (Japan)
2006
Saitama International Medical Center
1998-2001
Vitamin A nutritional status has been implicated as important in maintaining the integrity of immune functions. We have determined effect vitamin (retinol) depletion on ability young animals to produce antibodies after challenge with various bacterial antigens. Male Lewis rats raised A-free or adequate diets were immunized either near 40 days age, before signs deficiency apparent, 47 age when symptoms beginning be manifest. For polysaccharide antigens from Streptococcus pneumoniae Neisseria...
SUMMARY In order to elucidate the pathogenic role(s) of autoantibodies in connective tissue disease (CTD), we examined whether against U1-ribonucleoprotein (RNP) and double-stranded (ds) DNA can up-regulate ICAM-1, ELAM-1 class I II MHC molecule expression on pulmonary artery endothelial cells (HPAEC). HPAEC cultured presence anti-U1-RNP-containing anti-dsDNA-containing IgG from CTD patients was up-regulated significantly comparison with that normal healthy volunteers. Affinity...
Summary In order to elucidate the immunological properties of anti-U1-ribonucleoprotein (RNP) antibody, one autoantibodies detected in patients with connective tissue diseases (CTDs), we tested endothelial cell-binding by anti-U1-RNP antibodies and epitopes on human pulmonary artery cells (HPAECs) which autoantibody bound. IgG fractions positive for from CTDs bound HPAECs. Furthermore, intact F(ab′)2 purified affinity chromatography also cells. The binding activity could be effectively...
We have previously shown that vitamin A deficiency severely impairs the young rat's ability to produce specific antibodies after primary immunization with tetanus toxoid (TT). In present studies, we asked whether immunologic memory TT is established even in A-depleted animal, and if so, such can be elicited subsequent repletion retinol. Vitamin rats produced very low concentrations of TT-specific IgM IgG both secondary responses; however, ratios anti-TT were normal. When repleted retinol 1...
A dextran sulphate gel column removed anti-double-stranded DNA antibodies (anti-dsDNA) selectively, efficiently, and safely from the circulation of a patient with systemic lupus erythematosus (SLE). The mechanism removal is thought to be due cross reactivity anti-dsDNA sulphate, which has negatively charged units. Selective expected contribute not only treatment but also elucidation pathogenesis SLE.
Objective Although magnetic resonance imaging (MRI) is the gold standard for evaluating abnormal myocardial fibrosis and extracellular volume (ECV) of left ventricular myocardium (LVM), a similar evaluation has recently become possible using computed tomography (CT). In this study, we investigated diagnostic accuracy new 256-row multidetector CT with low tube-voltage single energy scan deep-learning-image reconstruction (DLIR) in detecting late enhancement (LE) LVM. Methods We evaluated...
later, follow-up CT showed ECV on the apical LVM (Figure I,J).Cardiac MRI is useful for detecting transient myocardial edema in acute phase of TTS. 1 As far as we know, this first report revealing reversibility CT-ECV elevation caused by
An enzyme linked immunosorbent assay (ELISA) was used to estimate the production of intracellular and extracellular interleukin-1 (IL-1) alpha beta by peripheral blood monocytes from 26 patients with various connective tissue diseases (CTD), including 19 systemic lupus erythematosus, four progressive sclerosis, two mixed disease, one Sjögren9s syndrome. Monocytes obtained CTD serum antibodies nuclear ribonucleoprotein (nRNP) released significantly higher concentrations IL-1 beta, whereas...
Antibodies to dsDNA are characteristically present in serum from patients with systemic lupus erythematosus (SLE), and have been shown the capacity react various molecules bearing repeating negative charges. After a number of polymeric or monomeric differently charged groups hydrophobic had coupled covalently as ligands on cellulose gel, adsorption capacities for anti-dsDNA antibodies were evaluated. It was found that gels polyanionic dextran sulphate (DXS) polyacrylic acid (PA) monoanionic...
We conducted a study to develop an assessment sheet for fall prediction in stroke inpatients that is handy and reliable help ward staff devise prevention strategy each inpatient immediately upon admission.The consisted of three steps: (1) developing data sampling form record variables related risk falls conducting follow-up survey from their admission discharge by using the form; (2) carrying out analyses characteristics present subjects selecting showing high hazard ratio (HR) Cox...