A5089051443- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Nitric Oxide and Endothelin Effects
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Trigeminal Neuralgia and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Pituitary Gland Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Cardiac Ischemia and Reperfusion
- Neurofibromatosis and Schwannoma Cases
- Cerebral Venous Sinus Thrombosis
- Calpain Protease Function and Regulation
- Moyamoya disease diagnosis and treatment
- Nerve injury and regeneration
National Defense Medical College Hospital
2011-2024
National Defense Medical College
2015-2024
JR Tokyo General Hospital
2019-2021
Juntendo University Shizuoka Hospital
2017
Juntendo University
2017
Shinshu University
2017
Harvard University
2017
University of Shizuoka
1995-2008
Ehime University
2007
The University of Tokyo
1980-2004
To elucidate the pathogenic contribution of a potent vasoconstrictor, endothelin-1, to coronary artery spasm, we provoked spasm with intracoronary administration acetylcholine or ergonovine and performed sensitive immunoassays plasma levels endothelin-1 atrial natriuretic factor (ANF) in peripheral vein sinus patients tentative diagnosis vasospastic angina (VSA, n = 19). The validity blood sampling was verified by simultaneous measurement ANF level. venous spasm-provoked (n 12) were...
Chronic subdural hematoma (CSDH) is a common condition after head trauma. It can often be successfully treated surgically by inserting bur hole and draining the liquefied hematoma. However, to best of authors' knowledge, for nonemergency cases not requiring surgery, no reports have indicated approach preventing enlargement or resolving it completely. The authors hypothesized that hyperfibrinolysis plays major role in liquefaction Therefore, they evaluated ability an antifibrinolytic drug,...
The endothelin (ET) family of peptides acts via two subtypes G-protein-coupled heptahelical receptors termed ETA and ETB, which have distinct rank orders affinity to receptor agonists antagonists. To delineate portions the molecules determine ligand selectivity, we constructed a series chimeras between human ETB characterized chimeric expressed in heterologous cell lines by competitive radioligand binding analysis measuring agonist-induced transients intracellular Ca2+. We demonstrate that...
BACKGROUND: xCT is a light chain of the cystine/glutamate antiporter system xc−. Glutamate that released by xc− plays an important role in infiltration glioblastoma (GBM) cells. Furthermore, increased glutathione synthesis may protect tumor cells against oxidative stress induced radiotherapy and chemotherapy. OBJECTIVE: To investigate whether levels expression correlated with infiltrative imaging phenotypes on magnetic resonance outcomes patients GBMs. METHODS: Forty histologically confirmed...
We report an invasive mycosis case in Japan caused by Bjerkandera adusta, a fungal species not previously reported as causative pathogen of mycosis. B. adusta was identified using phylogenetic analysis. Voriconazole used successfully for treatment. Immunodeficient patients may be susceptible to infection rare fungi.
Abstract Purpose The diagnosis of adolescent lumbar spondylolysis typically requires computed tomography (CT) imaging; however, concerns regarding medical radiation exposure have emerged. With recent advancements in magnetic resonance imaging (MRI), it has become possible to acquire CT-like images using an MR bone approach. This study aimed investigate whether can be utilised as a substitute for CT evaluating the fracture line patients with spondylolysis. Methods We included 24 (28 levels)...
Abstract Background Subarachnoid hemorrhage (SAH) often causes a prolongation of the corrected QT (QTc) interval during acute phase. The aim present study was to examine independent risk factors for QTc in patients with SAH by means multivariate analysis. Method We studied 100 who were admitted within 24 hours after onset SAH. Standard 12-lead electrocardiography (ECG) performed immediately admission. intervals measured from ECG and heart rate using Bazett formula. serum levels sodium,...
Poor-grade subarachnoid hemorrhage still has a poor prognosis. This randomized controlled clinical trial evaluated intracisternal magnesium sulfate infusion combined with intravenous hydrogen therapy in patients poor-grade hemorrhage. Thirty-seven were to Mg+H2, Mg, and control groups. Mg Mg+H2 groups received (2.5 mmol/L) at 20 mL/h for 14 days. group also hydrogen-rich solution Primary outcome measures occurrence of delayed cerebral ischemia vasospasm. Secondary modified Rankin Scale...
We investigated whether long-term infusion of kallikrein would attenuate renal injury in salt-induced hypertension Dahl salt-sensitive rats. A subdepressor dose purified rat urinary (700 ng/d IV) was infused by osmotic minipump for 4 weeks male rats fed a high salt (2% NaCl) diet. This did not affect the time-dependent elevation blood pressure; however, protein excretion significantly decreased, and glomerular filtration rate increased. These beneficial effects were reflected morphologically...
Ca2+ sensitivity of natural actomyosin (NAM) isolated from both the intact left ventricular free wall and an area myocardial infarction (MI) was analyzed by use superprecipitation response 2 to 48 h after anterior descending coronary artery ligation in dog. NAM tissue showed normal sensitivity. Four hours ligation, lowered only endocardial half MI region; it markedly decreased epicardial halves at 6 completely lost 24 h. A was, however, demonstrated all samples, indicating that myosin actin...
Decompressive craniectomy is one therapeutic option for severe traumatic brain injury (TBI), and it has long been used the treatment of patients with malignant post-traumatic edema. A lack definitive evidence, however, prevents physicians from drawing any conclusions about effects decompressive TBI. Therefore, aim present study was to investigate influence on edema formation. The aquaporin-4 (AQP4) water channel predominantly expressed in astrocytes, plays an important role regulation...
OBJECTIVE Microvascular decompression (MVD) is effective for the treatment of trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia. The transposition technique standard procedure to avoid adhesions granuloma around site but more complex difficult perform than interposition technique. authors describe a simple safe MVD they call "birdlime" technique, which uses tissue glue-coated collagen sponge soaked with fibrin glue, results this METHODS retrospectively...
Gap junctions are conductive channels formed by membrane proteins termed connexins (Cx), which permit the intercellular exchange of metabolites, ions, and small molecules. Junctional permeability is regulated pH, potential, intracellular secondary messengers. The purpose this study was to elucidate expression distribution astrocytic gap in hippocampus cortex after traumatic brain injury (TBI) vivo. Adult male Sprague-Dawley rats (300-400 g) were subjected lateral fluid percussion (FPI) at...
Abstract BACKGROUND Treatments for unruptured anterior communicating artery (AcomA) aneurysm have relatively high morbidity. OBJECTIVE To assess the lateral supraorbital keyhole approach safe and complete clipping of AcomA evaluate long-term clinical radiological outcomes, including cognitive depressive status. METHODS A total 63 patients (aged 41-79 yr, mean 64 yr) with small aneurysms clipped via were retrospectively analyzed among 105 treated by from 2005 to 2014. Neurological functions...
Genetic defects in several sarcoglycans (SGs) and dystrophin (Dys) play a critical role cardiomyopathy. The present study was designed to determine whether changes SGs Dys might occur animals with chronic heart failure (CHF) induced by acute myocardial infarction (AMI), which have no genetic defects.AMI the left coronary artery ligation (CAL) rats. hemodynamic parameters of 2- 8-week CAL (2w- 8w-CAL) rats were measured SGs, Dys, calpain, calpastatin levels determined Western blot method....