A5000041289- Pain Mechanisms and Treatments
- Periodontal Regeneration and Treatments
- Spinal Cord Injury Research
- Platelet Disorders and Treatments
- Hemostasis and retained surgical items
- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Shoulder Injury and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Hip disorders and treatments
- Surgical Sutures and Adhesives
- Pharmacological Effects of Natural Compounds
- Orthopedic Infections and Treatments
- Peripheral Neuropathies and Disorders
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Bacterial Identification and Susceptibility Testing
- Infectious Diseases and Tuberculosis
- Plant Toxicity and Pharmacological Properties
- Reconstructive Surgery and Microvascular Techniques
- Spine and Intervertebral Disc Pathology
- Dental Implant Techniques and Outcomes
- Vascular Malformations and Hemangiomas
- Peripheral Nerve Disorders
- Bone fractures and treatments
Chiba University
2013-2024
Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell (iPSC)-derived megakaryocytes and (iMPs) are capable of providing a stable supply, holding promise as materials for novel platelet concentrate-based therapies. In this context, we evaluated the effect iMPs on...
ABSTRACT Autologous vein wrapping is used to treat recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, its use restricted due the inability obtain sufficiently long veins for larger grafts. We previously reported that vein‐derived basic fibroblast growth factor (bFGF) promotes heme oxygenase‐1 (HO‐1), which reduces allodynia via anti‐inflammatory properties. To mimic wrapping, we developed a collagen sheet impregnated with bFGF. Chronic injury (CCI) was...
Platelet-rich plasma (PRP) promotes bone union through osteoinduction. We investigated whether adding demineralized matrix (DBM), derived naturally from biomaterial and with various growth factors, for osteoconductivity marrow fluid osteogenesis results in different unions. Eight-week-old male Sprague-Dawley rats were divided into four groups of five based on transplantation material: sham control (C group); DBM alone (D + PRP (DP (DPB group). After posterolateral fusion at L3-5,...
Abstract Background Autologous vein wrapping (VW) is used in the treatment of recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, use autologous veins limited by inability to obtain longer sufficient length for larger sites. Frozen allograft tissue has several advantages, including its availability large grafts, avoidance donor-site morbidity, shorter operation time. Here, we investigated effect frozen (FVW) Wistar rats as a model sciatic Results The...
Decompression surgery (DS) is a standard treatment for chronic nerve compression injuries; however, the mechanisms underlying its effects remain unclear. Here, we investigated of DS on messenger RNA (mRNA) expression tumor necrosis factor-α (TNF-α) and T cell recruitment in rat sciatic (SN) constriction injury (CCI) model. Male Wistar rats were subjected to CCI establish model SN (CCI group). DS, which all ligatures removed, was performed 3 days after + dec Mechanical sensitivity assessed...
<title>Abstract</title> Background Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell (iPSC)-derived megakaryocytes and (iMPs) are capable of providing a stable supply, holding promise as materials for novel platelet concentrate-based therapies. In this...
Abstract Co‐administration of mirogabalin besylate and nonsteroidal anti‐inflammatory drugs is effective for neuropathic pain; however, mechanism its action remains unknown. We aimed to evaluate the this synergistic effect concomitant administration pain using chronic constriction injury model rats. Fifty male Wister rats 7‐week‐old were used. Right sciatic nerve ligation was performed in 40 they sub‐divided into four groups: vehicle, mirogabalin, diclofenac sodium co‐administration them....
Background: Thorough debridement may be required to control bone and soft-tissue infections; however, we have tried continuous local antibiotic perfusion (CLAP) therapy with minimal debridement. CLAP perfuses the infection site a high concentration of antibiotics eradicate attached bacteria. The aim this study was demonstrate effectiveness by presenting cases in which even refractory infections caused hypervirulent Klebsiella pneumoniae could cured without significant tissue loss...
Abstract Background Autologous vein wrapping (VW) is used in the treatment of recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, use autologous veins limited by inability to obtain longer sufficient length for larger sites. Frozen allograft tissue has several advantages, including its availability large grafts, avoidance donor-site morbidity, shorter operation time. Here, we investigated effect frozen (FVW) Wistar rats as a model sciatic Methods The...