A5078499547- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
Chiba University
2022-2023
Allergic rhinitis is a growing problem worldwide. Currently the only treatment that can modify disease antigen-specific immunotherapy, but its mechanism of action not fully understood.We comprehensively investigated role and changes T cells before after sublingual immunotherapy (SLIT) for Japanese cedar pollinosis.We cultured peripheral blood mononuclear obtained both 1 year initiating SLIT used combination single-cell RNA sequencing repertoire sequencing. To investigate biomarkers, we from...
Uncontrolled type 2 immunity by helper T (Th2) cells causes intractable allergic diseases; however, whether the interaction of CD4 + shapes pathophysiology diseases remains unclear. We identified a subset Th2 that produced serine proteases granzyme A and B early in differentiation. Granzymes cleave protease-activated receptor (Par)-1 induce phosphorylation p38 mitogen-activated protein kinase (MAPK), resulting enhanced production IL-5 IL-13 both mouse human cells. Ubiquitin-specific protease...