A5042185791- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Photoreceptor and optogenetics research
- Connexins and lens biology
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Retinal and Macular Surgery
- Traumatic Ocular and Foreign Body Injuries
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ocular and Laser Science Research
- Retinal Imaging and Analysis
- Visual perception and processing mechanisms
- Systemic Lupus Erythematosus Research
- Anorectal Disease Treatments and Outcomes
- Ocular Disorders and Treatments
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
Iwate Medical University
2014-2025
Teikyo University
2015
Dokkyo Medical University Saitama Medical Center
2015
Keio University
1997-2006
Ophthalmology Associates (United States)
2004
Tokyo Medical Center
2004
National Sagamihara Hospital
1991
In Brief Purpose: To examine predictive factors for visual acuity in highly myopic eyes. Methods: Consecutive patients with high myopia (≥6 diopters [D]) no other pathology such as lacquer cracks the fovea, choroidal neovascularization, or macular schisis, were evaluated. The study was performed 2 retina centers, one United States and Japan. Enhanced depth imaging optical coherence tomography obtained, central foveal, outer retinal hyporeflective layer inner segment to pigment epithelium...
To investigate whether there is a significant correlation between the photopic negative response (PhNR) of electroretinogram (ERG) and retinal nerve fiber layer thickness optic disc topography in glaucomatous eyes.Ninety-nine eyes 53 patients with open-angle glaucoma (OAG) 30 28 normal volunteers were studied. Photopic ERGs elicited by red stimuli (644 nm, 1600 cd/m(2)) on blue background (470 40 cd/m(2)). The mean deviation (MD) visual field was obtained static analyses. head determined...
To investigate sequence variations in the optineurin (OPTN) gene and their association with TNF-alpha polymorphisms Japanese patients glaucoma.The OPTN was analyzed blood samples from 629 subjects. There were 194 primary open-angle glaucoma (POAG), 217 normal-tension (NTG), 218 no eye disease (control subjects). The screened for mutations by denaturing high-performance liquid chromatography. Genotyping of three -308G-->A, -857C-->T, -863C-->A promoter region performed. associations between...
To determine the clinical importance of photopic negative response (PhNR) focal electoretinogram (fERG) for diagnosing glaucoma.Fifty-nine eyes 38 patients with open-angle glaucoma (OAG), 12 suspects, and 32 normal controls were studied. The fERGs elicited by a 15 degrees stimulus spot on macula region, supero-temporal, infero-temporal regions macula. mean visual sensitivity was measured standard automated perimetry (SAP). optimal cutoff amplitudes PhNR ratios PhNR/b-wave that discriminated...
The Great East Japan Earthquake of March 11, 2011 triggered powerful tsunami waves off the northeastern Pacific coast that destroyed almost all built-up areas along coast. study reported here examined role played by Vision Van, a mobile outpatient ophthalmological clinic, in providing eye care to disaster evacuees.This was retrospective case-series 2,070 victims (male: 732, female: 1,338) who visited Van. subjects' medical records were retrospectively and analyzed terms age, sex, date visit...
We compared the effect of biconvex and convex-piano (posterior piano) intraocular lenses on posterior capsule opacification (PCO) following continuous curvilinear capsulorhexis (CCC) in 212 eyes. During three years surgery, cumulative frequency neodymium:YAG laser capsulotomy, calculated with Kaplan-Meier method, was significantly higher patients group (32.5% by third year) than those (5.9% (P < .05, Wilcoxon’s test; P .01, Cox-Mantel’s test). Measured tracing area within a 5 mm diameter...
Purpose: To determine the effect of glaucoma on multifocal electroretinograms (ERGs) (mfERGs) elicited by low-frequency stimuli.Methods: Forty-four patients with open-angle and 15 normal subjects were studied. The stimulus frequency was 6.25 Hz, a circle 6.8° radius that centered fovea (center). MfERGs also quarter an annulus placed around macula (superior/temporal; inferior/temporal; superior/nasal; inferior/nasal quadrants). inner border outer 20°. actual sensitivity determined standard...
Purpose: To determine regional variations in a structure-function relationship, we correlated the photopic negative response (PhNR) of focal electoretinogram (ERG) with ganglion cell complex (GCC) thickness different retinal regions patients open angle glaucoma (OAG).
To determine whether the corneal arcus affects sealing of clear incision (CCI) in cataract surgery. This study was a retrospective cohort study. The patients were divided into two groups based on stromal hydration required to close CCI. classified according its degree as none, partial (if < 180 degrees), and circumferential ≥ degrees). Multiple logistic regression conducted identify independent variables such age at surgery, sex, laterality, surgical time, associated with CCI sealing. Among...
To report a case of Vogt-Koyanagi-Harada (VKH) disease in patient with retinitis pigmentosa (RP) the right eye and pigmented paravenous retinochoroidal atrophy (PPRCA) left eye. A 32-year-old woman history RP visited our hospital blurred vision She had headache for four days before onset loss. Slit-lamp examination revealed bilateral inflammation anterior chamber vitreous. Fundus retinal pigment epithelium (RPE) diffuse bone spicule pigmentation eye, as well peripapillary region extending...
Purpose: To compare the long-term clinical results of two small incision cataract surgery procedures. Setting: Seven centers in Japan. Methods: Two hundred eyes were randomly assigned to receive a silicone intraocular lens (IOL) through 3.2 mm or poly(methyl methacrylate) (PMMA) IOL 5.5 incision. Except for size and implantation technique, surgical methods identical. Uncorrected corrected visual acuity, keratometry, flare-cell intensity, specular microscopy, neodymium:YAG (Nd:YAG) laser...
Purpose . To compare the photopic negative response (PhNR) of full-field electroretinogram (ERG) to PhNR focal ERGs in detecting glaucoma. Methods One hundred and three eyes with glaucoma 42 normal were studied. Full-field elicited by red stimuli on a blue background. The a<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mrow><mml:mn>15</mml:mn></mml:mrow><mml:mo>∘</mml:mo></mml:msup></mml:mrow></mml:math>white stimulus spot centered macula, superotemporal or...
We report choroidal findings by means of enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) in a patient with idiopathic uveal effusion syndrome (IUES).A 41-year-old man was referred to us ciliochoroidal and non-rhegmatogenous retinal detachments. Sclerectomies sclerostomies were performed at the equator lower quadrants, resulting resolution EDI-OCT demonstrated low-reflective areas outer choroid. The subfoveal thickness measured vertically from border RPE inner...
The purpose of this study was to create a uniform, reproducible hardened lens nucleus and an anterior capsule in pig eye that approximate those the human for use cataract surgery training. nuclei elasticity reduced eyes by injecting with mixtures formalin alcohol (ethanol, 2-propanol, or both). A 30 gauge needle used pierce 3.0 mm from limbus. Then, 0.2 mL mixture injected. most effective formalin, ethanol, 2-propanol ratio 4:3:3. Fifteen minutes after injected, had nuclear grade III...
AIMS: To determine whether alpha smooth muscle actin (alpha-SMA), a marker for myofibroblastic cells, is present in lens epithelial cells (LECs) rabbit aphakic eyes. METHODS: Phacoemulsification was performed eyes, which were enucleated after surgery. Immunohistochemical methods used to detect alpha-SMA LECs. RESULTS: Five days surgery, the presence of positive LECs observed mainly around adhesive portion anterior capsule margin and posterior capsule. The wrinkled at portion. flattened with...
The involvement of downstream messengers transforming growth factor (TGF)-beta in the differentiation corneal fibroblasts into myofibroblasts was investigated. effects insulin-like (IGF)-I and binding protein (IGFBP)-3 upregulated by TGF-beta were examined human fibroblasts, possible IGF axis components wound healing assessed a mouse model.Human incubated with TGF-beta2 or IGF-I, to investigate IGF-II, IGFBP-3, type I collagen, alpha-smooth muscle actin (alpha-SMA) mRNA, as well IGFBP-3...
We describe four patients with idiopathic choroidal neovascularization (ICNV) who developed inflammatory chorioretinal diseases in the ipsilateral or contralateral eye.The medical records of 58 eyes an initial diagnosis ICNV (age range, 19-49 years; mean, 34.9 years) were reviewed.Of patients, 4 women (7.0%) moderate to high myopia 17-39 diseases. In Cases 1 and 2, white dots transiently seen deep retina eye, consistent clinical features multiple evanescent dot syndrome (MEWDS). Case 3,...