A5029483652- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Intraocular Surgery and Lenses
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Ocular Infections and Treatments
- Corneal Surgery and Treatments
- Drug-Induced Ocular Toxicity
- Retinopathy of Prematurity Studies
- Retinal Development and Disorders
- Pharmaceutical studies and practices
- Ocular Diseases and Behçet’s Syndrome
- Ocular Oncology and Treatments
- Pharmacology and Obesity Treatment
- Neurological Disorders and Treatments
- Cancer Treatment and Pharmacology
- Pharmacy and Medical Practices
- biodegradable polymer synthesis and properties
- Acne and Rosacea Treatments and Effects
Washington University in St. Louis
2013-2024
Columbia University Irving Medical Center
2023
Oak Ridge National Laboratory
2022
Tufts University
2021
Tongji University
2021
University of California, San Diego
2021
WestMountain Asset Management (United States)
2019
Capital University
2019
Stanford University
2010
National Institute of Standards and Technology
2009
<h3>Background</h3> Primary open-angle glaucoma (POAG) is one of the leading causes blindness in United States and worldwide. Three to 6 million people are at increased risk for developing POAG because elevated intraocular pressure (IOP), or ocular hypertension. There no consensus on efficacy medical treatment delaying preventing onset individuals with IOP. Therefore, we designed a randomized clinical trial, Ocular Hypertension Treatment Study. <h3>Objective</h3> To determine safety topical...
<h3>Background</h3> The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) individuals with elevated intraocular pressure (ocular hypertension) and no evidence glaucomatous damage. <h3>Objective</h3> To describe baseline demographic clinical factors predict which participants OHTS developed POAG. <h3>Methods</h3> Baseline data were collected prior to...
Kass at Department of Ophthalmology and Visual Sciences, Washington University School Medicine. Box 8096. 660 South Euclid Avenue, St. Louis, MO 63110, U.S.A.
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) major risk factor, but many patients have normal IOP. Colocalization Mendelian randomization analysis >240 POAG IOP genome-wide association study (GWAS) loci overlapping expression splicing quantitative trait (e/sQTLs) in 49 GTEx tissues retina...
<h3>Objectives</h3> (1) To develop a classification system for visual field (VF) abnormalities, (2) to determine interreader and test-retest agreement, (3) the frequency of various VF defects in Ocular Hypertension Treatment Study. <h3>Methods</h3> Follow-up VFs are performed every 6 months monitored abnormality, indicated by glaucoma hemifield test result or corrected pattern SDoutside normal limits. As January 1, 2002, 1636patients had 2509 abnormal VFs. Three readers independently...
• A 17-year-old girl had intraocular pressure readings of 30 to 40 mm Hg in both eyes, with normal visual fields and optic nerve heads. Medical treatment was unsuccessful lowering the IOP measurements substantially. The central corneal thickness 0.90 each eye absence edema. Cannulation left anterior chamber revealed an 11 Hg, while Perkins' Schiötz' tonometers gave 35 34 respectively. Previously, elevated tonometry been obtained by Goldmann's, Perkins', Schiötz', MacKay Marg's, pneumatic...
<h3>Objective</h3> To determine the frequency with which visual field abnormalities observed on follow-up fields for patients in Ocular Hypertension Treatment Study were confirmed retest. <h3>Methods</h3> Between April 1, 1994, and March 1999, 21,603 obtained from 1637 Study. When are outside normal limits Glaucoma Hemifield Test, Corrected Pattern Standard Deviation (<i>P</i><.05), or both, subsequent monitored to confirm abnormality. Abnormalities if they again abnormal Deviation, both;...
To compare the safety and efficacy of earlier vs later treatment in preventing primary open-angle glaucoma (POAG) individuals with ocular hypertension.One thousand six hundred thirty-six intraocular pressure (IOP) from 24 to 32 mm Hg 1 eye 21 fellow were randomized observation or topical hypotensive medication. Median time medication group was 13.0 years. After a median 7.5 years without treatment, received for 5.5 determine if there is penalty delaying we compared cumulative proportions...
As part of a study to assess the possible contribution lymphoid infiltration gastrointestinal mucosa occult blood loss or malabsorption 20 patients with chronic lymphocytic leukaemia (CLL) had lactulose hydrogen breath test. In 10 cases (50%) small intestinal peak was detected, suggesting bowel bacterial overgrowth, and this confirmed in seven by positive culture jejunal aspirate. Of test, radiological examination showed duodenal diverticulum two but no anatomical abnormalities other cases....
Endothelins (ET) have some effects on the regulation of aqueous humor dynamics. To investigate their possible role in glaucoma, we measured plasma and ET levels patients with without primary open-angle glaucoma.Plasma samples were obtained from 31 glaucoma 24 glaucoma. Measurements made by radioimmunoassay (RIA) for ETs following cross-reactivities: ET-1, ET-2, big 100%; ET-3, 70%.The ages (mean +/- SD) (72.3 10 years) normal subjects (72.8 8 similar (p = 0.92). There was no significant...
• We conducted a randomized, double-masked, long-term clinical trial to determine whether topical timolol therapy was effective in delaying or preventing the onset of glaucomatous damage moderate-risk ocular hypertensive subjects. In 62 patients, one eye chosen randomly receive twice daily while fellow received placebo. During course study, mean ± SD difference intraocular pressure between timolol-treated and placebo-treated eyes 2.3 2.6 mm Hg. Reproducible visual field loss developed 4 10...
In a retrospective study, 92 patients with ocular hypertension, ie, intraocular pressure of 21 mm Hg or higher, and no evidence glaucomatous visual field defects, were observed for five years. Visual defects developed in one both eyes 33 during the five-year follow-up period, while none detected remaining 59. Values suspected risk factors, determined at outset subjected to multivariate analysis use linear discriminant multiple logistic function. Models providing maximum separation two...
• Topical 0.125% and 0.25% clonidine hydrochloride were compared with 2% pilocarpine a placebo in double-masked crossover study. Both strengths of had an ocular hypotensive effect similar magnitude duration to pilocarpine. Clonidine both concentrations also significantly lowered systemic blood pressure. Further studies will be needed establish the value safety treatment glaucoma.