A5017942687- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Apelin-related biomedical research
- CRISPR and Genetic Engineering
- Telomeres, Telomerase, and Senescence
- Genetic Associations and Epidemiology
- Biomedical Ethics and Regulation
- Thyroid Disorders and Treatments
- Retinal Imaging and Analysis
- Genetics, Aging, and Longevity in Model Organisms
- Neuropeptides and Animal Physiology
- Inflammation biomarkers and pathways
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Intellectual Property and Patents
Centre for Eye Research Australia
2013-2023
The Royal Victorian Eye & Ear Hospital
2019-2023
The University of Melbourne
2013-2023
L V Prasad Eye Institute
2022
UK Biobank
2021
Australian College of Optometry
2011
A recent genome-wide association study (GWAS) identified six loci associated with central corneal thickness that also conferred risk of keratoconus (KC). We aimed to assess whether genetic associations existed for these KC or curvature in an independent cohort European ancestry.In total, 157 patients were recruited from public and private clinics Melbourne, Australia, 673 individuals without through the Genes Myopia Australia. The following single-nucleotide polymorphisms (SNPs) showed a...
Citation information: McBrien NA, Arumugam B, Gentle A, Chow A & Sahebjada S. The M4 muscarinic antagonist MT‐3 inhibits myopia in chick: evidence for site of action. Ophthalmic Physiol Opt 2011, 31 , 529–539. doi:10.1111/j.1475‐1313.2011.00841.x Abstract Purpose: It is well established that the broad‐band antagonist, atropine effective at inhibiting progression and does so by preventing elongation vitreous chamber eye. However, uncertainty remains as to whether this effect occurs...
We assessed the impact of keratoconus disease indicators in better eye and worse on quality life (QoL) using Vision Quality Life Index (VisQoL) multi-attribute utility instrument (MAUI).?tlsb -.01w?>Patients with completed six-item VisQoL measure. Visual acuity was a logMAR chart, corneal thickness keratometric values were measured by Scheimpflug imaging (Pentacam). Four status considered this study, namely best corrected visual (BCVA), average front curvature (Front Km), thinnest location...
Purpose A previous study has indicated suggestive association of the hepatocyte growth factor (HGF) gene with Keratoconus. We wished to assess this in an independent Caucasian cohort as well its corneal curvature. Participants Keratoconus patients were recruited from private and public clinics Melbourne, Australia. Non-keratoconic individuals identified Genes Myopia (GEM) total 830 used for analysis including 157 keratoconic 673 non subjects. Methods Tag single nucleotide polymorphisms...
Purpose: Keratoconus (KC) represents one of the leading causes corneal transplantation worldwide. Detecting subclinical KC would lead to better management avoid need for grafts, but condition is clinically challenging diagnose. We wished compare eight commonly used machine learning algorithms using a range parameter combinations by applying them our dataset and build models differentiate from non-KC eyes. Methods: Oculus Pentacam was obtain parameters on 49 39 control eyes, along with...
<h3>Importance</h3> Keratoconus is a condition in which the cornea progressively thins and protrudes conical shape, severely affecting refraction vision. It major indication for corneal transplant. To discover new genetic loci associated with keratoconus better understand causative mechanism of this disease, we performed genome-wide association study on patients keratoconus. <h3>Objective</h3> identify susceptibility regions human genome. <h3>Design, Setting, Participants</h3> This was...
<h3>Importance</h3> Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high (HM) hyperopia. Addressing this question is fundamental understanding genetics of refractive error has clinical relevance for genotype-based prediction children at risk HM identification new therapeutic targets. <h3>Objective</h3> To assess a common set HM, LM, <h3>Design, Setting, Participants</h3> This association study assessed unrelated...
High myopia (HM), defined as a spherical equivalent refractive error (SER) ≤ -6.00 diopters (D), is leading cause of sight impairment, through myopic macular degeneration (MMD). We aimed to derive an improved polygenic score (PGS) for predicting children at risk HM and test if PGS predictive MMD after accounting SER.
Purpose To assess anterior segment parameters of eyes with keratoconus (KC) at different clinical stages disease. Methods KC and non-KC patients were recruited from public private clinics in Melbourne, Australia. Axial length (AL), mean front corneal curvature (Front Km), back (Back central thickness (CCT), the apex (CTA), thinnest point (CTT), chamber depth (ACD), volume noted for all eyes. Results A total 181 individuals comprising 44 (24.3%) subclinical KC, 118 (65.2%) 19 (10.5%) control...
Keratoconus is typically diagnosed through changes at the anterior ocular surface. However, we wished to assess if macular parameter might also occur in these patients. We assessed posterior use of optical coherence tomography and compared a nonkeratoconus patient group. All subjects underwent clinical examination including thickness measurements. The generalized estimation equation model was used estimate means compare differences various measurements between keratoconus A total 129 eyes 67...
Abstract Importance This is the first study to estimate lifetime costs associated with keratoconus based on a questionnaire completed by patients and highlights significant economic burden of disease. As affects individuals from young age, as public health concern. Background Keratoconus disorder characterized corneal steepening thinning, leading reduced visual acuity. To date, there have been no studies evaluating patient's perspective. Design A randomized cross‐sectional undertaken in...
To investigate the performance of a machine learning model based on reduced dimensionality parameter space derived from complete Pentacam parameters to identify subclinical keratoconus (KC).All 1692 available were obtained imaging 145 KC and 122 control eyes. We applied principal component analysis (PCA) dataset reduce its dimensionality. Subsequently, we investigated random forest algorithm with increasing numbers components their optimal number for detecting eyes.The set was 267 using PCA....
The purpose of this study was to comprehensively evaluate the patient-reported quality-of-life (QoL) outcomes after corneal cross-linking for keratoconus.This Save Sight Keratoconus Registry used cross-sectional and longitudinal designs. For study, 532 patients with keratoconus (mean age 30.9 ± 11.9 years; 31.6% female) completed Outcomes Research Questionnaire (KORQ) 343 28.3 10.7 32.7% Impact Vision Impairment (IVI) questionnaires. Similarly, 39 24.2 8.4 23.1% KORQ 16 27.9 17.1 50.0% IVI...
Graves' disease is an autoimmune thyroid of complex inheritance. Multiple genetic susceptibility loci are thought to be involved in and it therefore likely that these can identified by genome wide association studies. This study aimed determine if a study, using pooling methodology, could detect genomic associated with disease.Nineteen the top ranking single nucleotide polymorphisms including HLA-DQA1 C6orf10, were clustered within Major Histo-compatibility Complex region on chromosome 6p21,...
To study the demographics and clinical profile of keratoconus (KC) presenting in pre-teen children India.This was a retrospective case series conducted as single-institutional at tertiary eye center India. A total 586 eyes from 294 KC patients (aged 12 years or less) without any active comorbid conditions were included study. Slit-lamp biomicroscopy used to document signs KC. Information on age; gender; reason for consultation; family history; history allergy, atopy, rubbing; manifest...
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles other approaches for vision correction. Common risk factors have been identified genome-wide association studies (GWAS), but great part the refractive error heritability still missing. Some this may be explained rare variants (minor allele frequency [MAF] ≤ 0.01.). We...
Keratoconus (KC) is a common corneal condition with an unknown gender predominance. Although numerous studies have investigated the genetic component of KC, no specific genes yet been attributed to condition. We recently reported posterior segment changes occurring in eyes KC patients. However, it not clear whether these are part pathogenesis or reflect anatomical features eye manifested by at cornea. Given retinal represent main characteristics observed age-related macular degeneration...
The Keratoconus International Consortium (KIC) will allow better understanding of keratoconus.Keratoconus is a disorder characterised by corneal elevation and thinning, leading to reduced vision. current gaps in this disease be discussed the need for multi-pronged multi-centre engagement enhance our keratoconus highlighted.KIC has been established address with aim collecting baseline as well longitudinal data on several fields.Keratoconus control (no condition) subjects from different sites...