A5023207846- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Body Composition Measurement Techniques
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Diabetes Management and Education
- Mobile Health and mHealth Applications
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Health and Lifestyle Studies
- Biomedical Ethics and Regulation
- Diabetes Management and Research
- Cardiovascular Health and Risk Factors
- Diet, Metabolism, and Disease
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2018-2025
Tecnológico de Monterrey
2015-2024
MSD (Mexico)
2024
European Atherosclerosis Society
2021
Houston Methodist
2011-2015
Methodist Hospital
2013
We developed a novel non-insulin-based fasting score to evaluate insulin sensitivity validated against the euglycemic-hyperinsulinemic clamp (EHC). also evaluated its correlation with ectopic fact accumulation and capacity predict incident type 2 diabetes mellitus (T2D).The discovery sample was composed by 125 subjects (57 without 68 T2D) that underwent an EHC. defined METS-IR as Ln((2*G0)+TG0)*BMI)/(Ln(HDL-c)) (G0: glucose, TG0: triglycerides, BMI: body mass index, HDL-c: high-density...
The functional conversion of white adipose tissue (WAT) into a with brown (BAT)-like activity, often referred to as "browning," represents an intriguing strategy for combating obesity and metabolic disease. We demonstrate that thyroid hormone receptor (TR) activation by synthetic agonist markedly induces program adaptive thermogenesis in subcutaneous WAT coincides restoration cold tolerance cold-intolerant mice. Distinct from most other browning agents, pharmacological TR dissociates the...
Adipose tissue distribution plays a crucial role in the development of cardiovascular complications. In particular, visceral adipose (VAT) has been linked to insulin resistance (IR) and disease (CVD). However, relationship between VAT, cardiac dysfunction meditation capacity VAT related IR not fully characterized. This cross-sectional study included adults living with type 2 diabetes (T2D). was measured using electrical bioimpedance also estimated Metabolic Score for Visceral Fat (METS-VF)....
Many pathogens colonize different anatomical sites, but the selective pressures contributing to survival in diverse niches are poorly understood. Group A Streptococcus (GAS) is a human-adapted bacterium that causes range of infections. Much effort has been expended dissect molecular basis invasive (sterile-site) infections, little known about genomes strains causing pharyngitis (streptococcal "sore throat"). Additionally, there essentially nothing genetic relationships between populations...
Patient empowerment is a continuous process in which knowledge, motivation, and capacity to take control of their disease are built within person. This concept not always well understood applied. review describes the strategies induce patients with diabetes. In addition, most common scales used evaluate diabetes described. Furthermore, effectiveness empowerment-based interventions for improving metabolic knowledge Finally, we discuss opportunities implementation clinical practice current...
Abstract Group A Streptococcus (GAS) is a human-adapted pathogen that causes variety of diseases, including pharyngitis and invasive infections. GAS strains are categorized by variation in the nucleotide sequence gene (emm) encodes M protein. To identify emm types causing Ontario, Canada, we sequenced hypervariable region 4,635 pharyngeal isolates collected during 2002–2010. The most prevalent varied little from year to year. In contrast, fine-scale geographic analysis identified inter-site...
Abstract The majority of cholesterol reduction therapies, such as the statin drugs, work primarily by inducing expression hepatic low-density lipoprotein receptors (LDLRs), rendering these therapeutics only partially effective in animals lacking LDLRs. Although thyroid hormones and their synthetic derivatives, often referred to thyromimetics, have been clearly shown reduce serum levels, this action has generally attributed ability increase Here we show for first time that hormone T3...
Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non-insulin-based IR indexes were developed as tools for screening. Here, we aimed to evaluate the novel non-insulin-based Metabolic Score (METS-IR) index prediction of incident hypertension stiffness evaluated using pulse wave velocity (PWV) analysis, compared other indexes. We two populations, a cross-sectional evaluation high-risk individuals (n = 305) wide range comorbidities...
Thyroid hormone receptor (TR) agonists have been proposed as therapeutic agents to treat non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We investigated the ability of TR GC-1 KB2115 reduce hepatic steatosis in ob/ob mice. Both compounds markedly reduced triglyceride levels ameliorated steatosis. However, amelioration was not sufficient improve sensitivity these mice reductions triglycerides did correlate with improvements or glycemic control. Instead, effects activation on...
Familial hypercholesterolemia (FH) is a genetic disorder driven in part by mutations three genes that encode components of the cholesterol pathway: LDLR, APOB, and PCSK9. However, majority FH genetics has been performed individuals European descent. Here, we leveraged cohort 300 patients from Mexican registry to understand how rare, high liability alleles common variants might contribute shaping individual risk. Using combination whole exome short- long-read genome sequencing, report key...
Objective A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for type 2 diabetes in Mexicans. We aim to investigate detailed metabolic profile carriers identify potential physiological mechanisms explaining risk. Design Cross-sectional study. Methods evaluated ( n = 72) non-carriers 75) haplotype, or without diabetes. An independent sample 1069 subjects was used replicate biochemical findings. The...
Familial hypercholesterolemia (FH) remains underdiagnosed and undertreated. Report the results of first years (2017-2019) Mexican FH registry. There are 60 investigators, representing 28 federal states, participating in The variables included accordance with European Atherosclerosis Society (EAS) recommendations. To date, 709 patients have been registered, only 336 complete data fields presented. mean age is 50 (36-62) average time since diagnosis 4 (IQR: 2-16) years. Genetic testing...
OBJECTIVE To assess whether an ethnic-specific variant (p.E508K) in the maturity-onset diabetes of young (MODY) gene hepatocyte nuclear factor-1α (HNF1A) found Mexicans is associated with higher sensitivity to sulfonylureas, as documented patients MODY3. RESEARCH DESIGN AND METHODS We recruited 96 participants (46 carriers and 50 age- sex-matched noncarriers). Response glipizide (one 2.5–5.0-mg dose), metformin (four 500-mg doses), oral glucose challenge was evaluated using a previously...
Familial hypertriglyceridemia (FHTG) is a partially characterized primary dyslipidemia which frequently confused with other forms hypertriglyceridemia. The aim of this work to search for specific features that can help physicians recognize disease.This study included 84 FHTG cases, 728 subjects common mild-to-moderate (CHTG) and 609 normotriglyceridemic controls. All underwent genetic, clinical biochemical assessments. A set 53 single nucleotide polymorphisms (SNPs) previously associated...