A5062702433- Pituitary Gland Disorders and Treatments
- Diabetes Treatment and Management
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Cytokine Signaling Pathways and Interactions
- Diet, Metabolism, and Disease
- Intraperitoneal and Appendiceal Malignancies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aortic Thrombus and Embolism
- Nuclear Structure and Function
- Lipoproteins and Cardiovascular Health
- Appendicitis Diagnosis and Management
- Vascular Malformations and Hemangiomas
- Thyroid Cancer Diagnosis and Treatment
- Science, Research, and Medicine
- Vascular Tumors and Angiosarcomas
- Botulinum Toxin and Related Neurological Disorders
- Neuroblastoma Research and Treatments
- Radiology practices and education
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2019-2024
Hospital del Niño
2022-2023
Moffitt Cancer Center
2018-2019
Medical College of Wisconsin
2013
Cushing's disease (CD) is a life-threating disease, with increased mortality in comparison the general population.This study aimed to evaluate standardized ratios (SMRs) CD patients. We also analyzed independent risk factors related mortality.We conducted longitudinal cohort 3rd level specialty center, from 1979 2018, patients CD.From 1375 cases pathology diagnosis of pituitary adenoma, 191 had confirmed (14%). A total 172 completed follow-up, mean age at 33 ± 11 years, female predominance...
Familial hypertriglyceridemia (FHTG) is a partially characterized primary dyslipidemia which frequently confused with other forms hypertriglyceridemia. The aim of this work to search for specific features that can help physicians recognize disease.This study included 84 FHTG cases, 728 subjects common mild-to-moderate (CHTG) and 609 normotriglyceridemic controls. All underwent genetic, clinical biochemical assessments. A set 53 single nucleotide polymorphisms (SNPs) previously associated...
Abstract Introduction The role of insulin resistance in diabetic chronic complications among individuals with type 1 diabetes (T1D) has not been clearly defined. aim this study was to examine the performance resistance, evaluated using estimated glucose disposal rate (eGDR) for identification metabolic syndrome (MS) and complications. Methods Cross‐sectional a tertiary care centre. We included patients 18 years older, at least 6 months T1D duration. Anthropometric, clinical biochemical data...
Currently, research in physiology focuses on molecular mechanisms underlying the functioning of living organisms. Reductionist strategies are used to decompose systems into their components and measure changes physiological variables between experimental conditions. However, how these isolated translate emergence -and collapse- biological functions organism as a whole is often less tractable question. To generate useful representation system, known unknown interactions heterogeneous must be...
Synchronous parathyroid and papillary thyroid carcinoma are extremely rare. To our knowledge, only 15 cases have been reported in the last four decades. We describe a 50-year-old female without significant past medical or family history no previous trauma presented with left heel pain that prompted her to seek attention. Physical examination was notable for painless nodule at lobe. Laboratory evaluation showed serum calcium level of 14.3 mg/dL (8.6-10.3 mg/dL) intact hormone 1160 pg/mL...
Ectopic ACTH-secretion causing Cushing's syndrome is unusual and its diagnosis frequently challenging. The presence of high-molecular-weight precursors throughout pro-opiomelanocortin (POMC) translation by these tumors often not reported. We present the case a 49-year-old woman with three-month history proximal muscular weakness, skin pigmentation, weight loss. Upon initial evaluation, she had full moon face, hirsutism, buffalo hump. Laboratory workup showed hyperglycemia, hypokalemia...
Accumulating clinical evidence indicates an inverse relationship between oxidative stress and unconjugated hyperbilirubinemia. This study aimed to compare the prevalence of diabetes microvascular complications in patients with Gilbert syndrome type 2 mellitus (T2D).A total 1200 electronic records T2D were reviewed. From them, 50 (cases [indirect bilirubin ≥1.2 mg/dl without hemolysis or liver disease]) controls (T2D hyperbilirubinemia) included. Linear logistic regression models performed...
<title>Abstract</title> <bold>Context: </bold>Dopamine agonists (DA), mainly cabergoline, are the primary therapy for prolactinomas. Risks factors related with biochemical recurrence after DA withdrawal not completely understood. <bold>Objective: </bold>To assess hyperprolactinemia risk dopamine agonist (DA) in <bold>Design: </bold>Retrospective, comparative, observational cohort study. Survival, and multivariate regression analyses were performed to estimate remission (prolactin (PRL) 3-25...
Liposarcoma is the most common histotype of retroperitoneal sarcomas, representing up to 45% all cases. We report a rare combination acromegaly and liposarcoma in same individual.Laboratory imaging studies including an oral glucose tolerance test, measurements growth hormone (GH) insulin-like factor-1 (IGF-1), computed tomography scan were performed.The patient was 60-year-old male with history diagnosed on basis elevated IGF-1 at 1,373 ng/mL (age-appropriate reference range 87 225 ng/mL)...
There are several methods to assess the function of autonomic nervous system. Among them, heart rate recovery (HRR) is an accepted, easy, low-cost technique. Different pathological conditions have been related development dysfunction. Our study aimed evaluate relationship between HRR and HRR-derived parameters in ambulatory patients with asthma or type 2 diabetes followed at National Institutes Health Mexico City. A total 78 participants, 50 women and, 28 men were enrolled; anthropometric,...
TPS5596 Background: There is no consistent recommendation for management of metastatic cervical cancer beyond first line therapy with chemotherapy and bevacizumab. Pembrolizumab now approved PD-L1 positive or MSI-H/dMMR recurrent cancer. Numerous pre-clinical studies have provided evidence to combine radiation immune checkpoint inhibition improve response rates. The strongest short course, hypofractionated regimens. We hypothesize treatment atezolizumab will objective rate (ORR) compared...
To describe a case of maturity-onset diabetes the young (MODY) to highlight importance correct diagnosis.We Mexican family misdiagnosed with T1D and T2D.A 36-year-old woman adverse outcomes during 2 pregnancies had been diagnosed T2D 10 years ago. Genetic testing was performed due clinical history, which showed pathogenic heterozygous variant c.544G>T (p.Val182Leu) in GCK gene. This mutation also confirmed most members who diabetes.This highlights need for classification. Reassessment...
Inherited MYC-associated factor X (MAX) gene pathogenic variants (PVs) increase risk for pheochromocytomas (PCCs) and/or paragangliomas (PGLs) in adults and children. There is little clinical experience with such mutations.This report highlights an important approach.Clinical assessment, including blood chemistry, imaging studies, genetic testing were performed.A 38-year-old Hispanic woman was diagnosed PCC 2015, treated adrenalectomy, referred to endocrinology clinic. Notably, she presented...
Adrenal cystic lymphangiomas are unusual entities with a very low prevalence that typically discovered incidentally. We describe 45-year-old male known for hypertension was referred to our endocrinology department right adrenal incidentaloma. Seven months prior referral, he presented hypochondrium pain, vomiting and nausea imaging studies included computer tomography revealed an irregular-shaped lesion (42 × 23 mm), scattered calcifications in the medial branch heterogenous contrast...
Background: Homozygous familial hypercholesterolemia (HoFH), a very rare autosomal dominant disease, mainly caused by LDL receptor (LDL-R) alterations, with aortic valve compromise reaching nearly 100% and vascular calcifications that can progress independently of marked decrease in total cholesterol levels. Clinical case: A 21-year-old Hispanic woman diagnosed HoFH at the age 6 was referred to our hospital for follow up. Her father had died acute myocardial infarction 40. mother an LDLc 309...
Introduction Pituitary adenomas represent approximately 15% of all intracranial neoplasms. Those with the ability to produce more than one hormone are called plurihormonal pituitary adenomas. They divided into monomorphic, single cell type may produces two or hormones, and plurimorphic, different types multiple hormones. Materials methods We performed a retrospective review patients diagnosed hyperprolactinemia acromegaly secondary adenoma during period 2004-2018. Then, we identified 10 high...