A5018644231- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Air Quality Monitoring and Forecasting
- Fluoride Effects and Removal
- Energy and Environment Impacts
- COVID-19 Clinical Research Studies
- Heart Rate Variability and Autonomic Control
- Pregnancy and preeclampsia studies
- Acute Kidney Injury Research
- Health and Lifestyle Studies
- Neurological Disorders and Treatments
- Bone and Dental Protein Studies
- Osteoarthritis Treatment and Mechanisms
- Occupational and environmental lung diseases
- Heavy Metal Exposure and Toxicity
- Advanced Glycation End Products research
- Radioactivity and Radon Measurements
- Therapeutic Uses of Natural Elements
- Per- and polyfluoroalkyl substances research
- Vanadium and Halogenation Chemistry
- T-cell and B-cell Immunology
- Oral microbiology and periodontitis research
- Health, Environment, Cognitive Aging
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
Instituto Politécnico Nacional
2015-2025
Center for Research and Advanced Studies of the National Polytechnic Institute
2015-2025
Instituto Nacional de Ecología y Cambio Climático
2024
Instituto Nacional de Enfermedades Respiratorias
2018-2022
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2018-2021
National Institute of Cardiovascular Diseases
2021
Particulate matter exposure is associated with respiratory and cardiovascular system dysfunction. Recently, we demonstrated that fine particles, also named PM2.5, modify the expression of some components angiotensin bradykinin systems, which are involved in lung, cardiac renal regulation. The endocrine kidney function regulation bradykinin, it can suffer damage even as a consequence minor alterations these systems. We hypothesized to PM2.5 contribute early an angiotensin/bradykinin...
Particulate matter (PM) adverse effects on health include lung and heart damage. The renin-angiotensin-aldosterone (RAAS) kallikrein-kinin (KKS) endocrine systems are involved in the pathophysiology of cardiovascular diseases have been found to impact diseases. aim present study was evaluate whether PM exposure regulates elements RAAS KKS.Sprague-Dawley rats were acutely (3 days) subchronically (8 weeks) exposed coarse (CP), fine (FP) or ultrafine (UFP) particulates using a particulate...
In recent years, nanomaterials have been used in the medical-dental field as new alternative antimicrobial agents. Bismuth subsalicylate (BSS) has an agent, but effect of BSS form nanoparticles (BSS-nano) a potential agent not tested, specific against bacteria responsible for periodontal disease. The aim this study was to evaluate antibacterial BSS-nano oral anaerobic and assess safety by evaluating their cytotoxicity human gingival fibroblast (HGF-1) cells. were synthesized laser ablation...
The present study evaluated urinary oxidative stress (OxS) biomarkers to explain the extrapulmonary effect of renal function decline due subchronic inhalation exposure particles smaller than 2.5 μm, as well correlation with particles' endotoxin content. Adult male Sprague-Dawley rats were exposed μm (8 weeks, 4 days/week, 5 h/day). control group was filtered air. MiniVol and HiVol samplers used estimate concentration collected particles, respectively. Biomarkers assessed in weekly urine...
Exposure to particulate matter (PM) has been implicated in oxidative stress (OxS) and inflammation as underlying mechanisms of lung damage cardiovascular alterations. PM is a chemical mixture that can be subdivided according their aerodynamic size into coarse (CP), fine (FP), ultrafine (UFP) particulates. We investigated, rat model, the induction OxS (protein oxidation antioxidant response), carcinogen-DNA adduct formation, inflammatory mediators response different airborne fractions, CP,...
Abstract Background Anthropogenic vanadium (V) emissions and exposure in the general population have recently increased. Experimental studies shown that V is a nephrotoxic agent, but little known about its effects on human kidney health. This work evaluated association between urinary concentrations with early damage biomarkers function pediatric without any disease diagnosed. Methods A cross-sectional study was carried out included 914 healthy subjects determined concentrations, glomerular...
Even though smoking has been scarcely studied in osteoarthritis (OA) etiology, it is considered a controversial risk factor for the disease. Exposure to tobacco smoke reported promote oxidative stress (OS) as part of damage mechanism. The aim this study was assess whether increases cartilage through generation OS. Peripheral blood (PB) and synovial fluid (SF) samples from patients with OA were analyzed. stratified according habit, Kellgren–Lawrence score, pain, cotinine concentrations PB....
Background: Coronavirus infectious disease 2019 (COVID-19) is a significant public health problem worldwide. COVID-19 increases the risk of non-pulmonary complications such as acute myocardial injury, renal failure, thromboembolic events, and multi-organic damage. Several studies have documented increased inflammation molecules, endothelial dysfunction biomarkers, dysregulation coagulation factors in patients. In addition, endothelium exacerbated by oxidative stress (OxS) promoted endocrine...
Abstract Background SARS-CoV-2 is a systemic disease that affects endothelial function and leads to coagulation disorders, increasing the risk of mortality. Blood levels biomarkers such as Von Willebrand Factor (VWF), Thrombomodulin or Dendritic Cell Antigen-3 (BDCA3), uUokinase (uPA) increase in patients with severe can be prognostic indicators for Therefore, aim this study was determine effect VWF, BDCA3, uPA on Methods From May 2020 January 2021, we studied prospective cohort hospitalized...
Exposure to high levels of particulate matter <2.5 µm (PM2.5) causes cardiorespiratory diseases due oxidative stress and inflammation. The toxicity PM2.5 depends on particle size composition. can reach organs far from the lungs, such as brain, heart, kidneys, adipose tissue, affecting their function. Moreover, endotoxin, an important component PM2.5, has recently been suggested a risk factor for development metabolic, autoimmune, neurodegenerative, renal diseases. Most published studies...
Currently, research in physiology focuses on molecular mechanisms underlying the functioning of living organisms. Reductionist strategies are used to decompose systems into their components and measure changes physiological variables between experimental conditions. However, how these isolated translate emergence -and collapse- biological functions organism as a whole is often less tractable question. To generate useful representation system, known unknown interactions heterogeneous must be...
Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression cardiovascular diseases promotes the biomineralization of blood vessels other soft tissues. Moreover, there an active component oxidative stress related with those diseases. The present study relates serum OPN levels nutritional condition group adolescents. Anthropometric measurements were performed, fasting samples analyzed to determine concentrations, chemistry parameters...
Inorganic fluoride is a geogenic and anthropogenic contaminant widely distributed in the environment commonly identified contaminated groundwater. There limited information on effect of exposure pregnancy. The aim this study was to evaluate possible placental alterations rat model simulating preconception pregnancy conditions endemic areas. Fluoride administered orally foetuses dams exposed 2.5 5 mg fluoride/kg/d. Foetal weight, height, foetal/placental weight ratio, zone thickness, levels...
Pleural effusion (PEf) is a pathophysiological condition that associated with the accumulation of pleural fluid (Pfl), presenting itself in diseases such as:pneumonia Obstructive Pulmonary Disease (COPD), pulmonary fibrosis, lung cancer and also due to cardiac conditions.The elemental composition PEf can serve as biomarker state comorbidities samples (N=129) were collected Metropolitan Area Valley Mexico emergency room service National Institute Respiratory Diseases (INER), during...
<title>Abstract</title> Currently, our understanding of the impact particulate matter on nephrotoxicity is limited. Oxidative stress has been identified as a mechanism involved in adverse health effects due to exposure this air pollutant, their inorganic, organic, and aerobiological constituents (e.g. endotoxin). The goal present study was correlate endotoxin content with urinary oxidative biomarkers explain early decline renal dysfunction. Adult male Sprague-Dawley rats exposed subchronic...