A5083168171- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Palliative Care and End-of-Life Issues
- Frailty in Older Adults
- Economic and Financial Impacts of Cancer
- Estrogen and related hormone effects
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Advanced Breast Cancer Therapies
- DNA Repair Mechanisms
- Cancer survivorship and care
- COVID-19 and healthcare impacts
- Patient-Provider Communication in Healthcare
- Global Public Health Policies and Epidemiology
- Women's cancer prevention and management
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Genomics and Rare Diseases
- PARP inhibition in cancer therapy
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2016-2025
Artistic Realization Technologies
2023
Universitas Achmad Yani
2021
City of Hope
2017-2018
Mission Hospital
2018
St. Joseph Medical Center in Tacoma
2018
Instituto Nacional de Enfermedades Neoplásicas
2018
Maricopa Medical Center
2018
City Of Hope National Medical Center
2018
Autonomous University of San Luis Potosí
2018
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following guideline development process as outlined in Methodology Manual . follow Conflict Interest Policy Clinical Practice other guidance (“Guidance”) provided by is not a or definitive guide to treatment options. It intended voluntary use providers should be used conjunction independent professional judgment. Guidance may applicable all patients,...
PURPOSE To guide clinicians and policymakers in three global resource-constrained settings on treating patients with metastatic breast cancer (MBC) when Maximal setting–guideline recommended treatment is unavailable. METHODS A multidisciplinary, multinational panel reviewed existing ASCO guidelines conducted modified ADAPTE formal consensus processes. RESULTS Four published resource-agnostic were adapted for settings; informing two rounds of consensus; recommendations received ≥75%...
Abstract Background. Breast cancer (BC) is the leading cause of malignancy-related deaths among women aged ≤45 years. There are unexplored and uncertain issues for BC in this particular group Latin America. The aim study to evaluate incidence mortality young related clinicopathological survivorship aspects region. Materials Methods. Data were obtained from Globocan 2008 International Agency Research on Cancer's Cancer Incidence Five Continents series plus databases. We requested...
Breast cancer is the most common malignancy in women Brazil. Differences between patients with public versus private healthcare coverage about general characteristics, disease presentation, treatment of primary tumors, and clinical outcomes have not been fully investigated.A national, retrospective cohort 3,142 drawn from a representative sample Brazilian medical centers was selected. Clinical demographic data type were retrieved by chart review. Groups compared using χ(2) test. The log-rank...
Abstract COVID-19 has overwhelmed the capacity of health care systems, limiting access to supportive and palliative for patients with advanced cancer. Telemedicine emerged as a tool provide continuity while risk contagion. However, implementing telemedicine in resource-limited settings is challenging. We report results multidisciplinary patient-navigator-led program Mexico City. One-hundred sixty-three interventions were provided 45 (median age 68, 57% female). A quarter had less than or...
Abstract Purpose The Palliative Care Study Group in conjunction with the Oral of Multinational Association for Supportive Cancer (MASCC) formed a sub-group to develop evidence-based guidance on management common oral problems patients advanced cancer. Methods This was developed accordance MASCC Guidelines Policy. A search strategy Medline developed, and Cochrane Database Systematic Reviews Central Register Controlled Trials were explored relevant reviews trials, respectively. Guidance...
Abstract Background. Breast cancer (BC) is the leading cause of malignancy-related deaths among women aged ≤45 years. There are unexplored and uncertain issues for BC in this particular group Latin America. The aim study to evaluate incidence mortality young related clinicopathological survivorship aspects region. Materials Methods. Data were obtained from Globocan 2008 International Agency Research on Cancer's Cancer Incidence Five Continents series plus databases. We requested...
Background: Tumor associated neutrophils (TAN) are related to aggressiveness and a poor prognosis with human cancers. However, the relevance of TAN in breast cancer has not been previously investigated here we sought determine their presence among different subtypes. Methods: We analyzed patients stage I-III cancers between 2006 2012. Tumors were divided into three subtypes: hormone-receptor [ HR]-positive, HER2-negative (HR+,HER2-ve); HER2-positive triple negative (TN). Hematoxylin eosin...
Abstract Background The early integration of supportive care in oncology improves patient-centered outcomes. However, data are lacking regarding how to achieve this resource-limited settings. We studied whether patient navigation increased access multidisciplinary among Mexican patients with advanced cancer. Materials and Methods This randomized controlled trial was conducted between August 2017 April 2018 at a public hospital Mexico City. Patients aged ≥18 years metastatic tumors ≤6 weeks...
PURPOSE To report on pathogenic germline variants detected among individuals undergoing genetic testing for hereditary breast and/or ovarian cancer (HBOC) from Latin America and compare them with self-reported Hispanic the United States. METHODS In this cross-sectional study, unrelated a personal/family history suggestive of HBOC who received clinician-ordered multigene sequencing were grouped according to location ordering physician: group A, Mexico, Central America, Caribbean; B, South...
PURPOSE Genetic cancer risk assessment (GCRA) provides pathogenic variant (PV) carriers with the invaluable opportunity to undertake timely risk-reducing (RR) measures and initiate cascade testing (CT). This study describes uptake of these strategies related barriers among breast cancer–associated germline PV in Mexico. METHODS Carriers who were at least 6 months after disclosure genetic test results two GCRA referral centers invited answer a survey assessing sociodemographic...
PURPOSE The purpose ot this study was to assess the effectiveness of an educational video compared in-person genetic counseling for cancer testing candidates. Genetic risk assessment is essential tailoring oncological treatment, identifying individuals at higher cancer, implementing risk-reduction strategies, and enabling family cascade testing. Pretest facilitates individual’s informed decision making reduces anxiety. However, availability genetics specialists limited in constrained...
Abstract We sought to uncover genetic drivers of hormone receptor–positive (HR+) breast cancer, using a targeted next-generation sequencing approach for detecting expressed gene rearrangements without prior knowledge the fusion partners. identified intergenic fusions involving driver genes, including PIK3CA, AKT3, RAF1, and ESR1, in 14% (24/173) unselected patients with advanced HR+ cancer. FISH confirmed corresponding chromosomal both primary metastatic tumors. Expression novel kinase...
Patient Navigation to Improve Access Breast Cancer Care in Brazil Noncommunicable diseases, such as cancer, are surpassing infectious diseases the most pressing health care threat low-and middle-income countries (LMICs). 1 By 2025, 59% of new cancer cases and 68% all deaths will occur LMICs, 2 systems these struggling respond this changing landscape. 3n Brazil, breast is common leading cause death among women, with 14,206 2013 4 57,960 diagnoses estimated for year 2016.