A5033780979- Pain Management and Opioid Use
- Palliative Care and End-of-Life Issues
- Oral health in cancer treatment
- Pediatric Pain Management Techniques
- Pharmacological Effects and Toxicity Studies
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Cancer Studies
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Salivary Gland Disorders and Functions
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Pain Management and Placebo Effect
- Gastrointestinal motility and disorders
- Mechanical Circulatory Support Devices
- Intestinal and Peritoneal Adhesions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Oral Health Pathology and Treatment
- Nausea and vomiting management
- Sleep and related disorders
- Cancer Treatment and Pharmacology
- Antifungal resistance and susceptibility
- Effects of Radiation Exposure
Trinity College Dublin
2021-2025
University College Dublin
2021-2025
Our Lady's Hospital
2021-2025
Maidstone Hospital
2024
University of Surrey
2017-2024
University of Maryland, Baltimore
2023
Imperial College London
2014-2023
Royal Surrey County Hospital
2012-2021
Royal Surrey NHS Foundation Trust
2020
Kingston Hospital
2018-2020
The novel influenza A(H1N1) pandemic affected Australia and New Zealand during the 2009 southern hemisphere winter. It caused an epidemic of critical illness some patients developed severe acute respiratory distress syndrome (ARDS) were treated with extracorporeal membrane oxygenation (ECMO).To describe characteristics all A(H1N1)-associated ARDS ECMO to report incidence, resource utilization, patient outcomes.An observational study (n = 68) in 15 intensive care units (ICUs) between June 1...
A task group of the Science Committee Association for Palliative Medicine Great Britain and Ireland (APM) was convened to produce some up-to-date, evidence-based, practical, clinical guidelines on management cancer-related breakthrough pain in adults. On basis a review literature, unable make recommendations about any individual interventions, but able series 12 certain generic strategies. However, most aforementioned are based limited evidence (i.e., case series, expert opinion). The also...
Abstract Introduction Higher lactate concentrations within the normal reference range ( relative hyperlactatemia ) are not considered clinically significant. We tested hypothesis that is independently associated with an increased risk of hospital death. Methods This observational study examined a prospectively obtained intensive care database 7,155 consecutive critically ill patients admitted to Intensive Care Units (ICUs) four Australian university hospitals. assessed relationship between...
Effective therapy has not been established for patients with agitated delirium receiving mechanical ventilation.To determine the effectiveness of dexmedetomidine when added to standard care in ventilation.The Dexmedetomidine Lessen ICU Agitation (DahLIA) study was a double-blind, placebo-controlled, parallel-group randomized clinical trial involving 74 adult whom extubation considered inappropriate because severity agitation and delirium. The conducted at 15 intensive units Australia New...
The optimal target for systemic oxygenation in critically ill children is unknown. Liberal widely practiced, but has been associated with harm paediatric patients. We aimed to evaluate whether conservative would reduce duration of organ support or incidence death compared standard care.
Cancer pain patients need variable opioid doses. Preclinical and clinical studies suggest that efficacy is related to genetic variability. However, the have small samples, findings are not replicated, several candidate genes been studied. Therefore, a study of variability with doses in large population using confirmatory validation was warranted. We recruited 2294 adult European World Health Organization (WHO) step III analyzed single nucleotide polymorphisms (SNPs) putative influence on...
Objective:The efficacy of intranasal fentanyl spray (INFS) was compared with that oral transmucosal citrate (OTFC) for the relief cancer-related breakthrough pain (BTP) in an open-label, crossover trial.Methods:Adult cancer patients receiving stable background opioid treatment and experiencing BTP episodes were recruited from 44 study centres seven European countries (Austria, France, Germany, Italy, Poland, Spain United Kingdom); 196 enrolled, 139 randomised to receive INFS followed by...
Rationale: Open lung ventilation strategies have been recommended in patients with acute respiratory distress syndrome (ARDS).Objectives: To determine whether a maximal recruitment strategy reduces ventilator-free days ARDS.Methods: A phase II, multicenter randomized controlled trial adults moderate to severe ARDS. Patients received recruitment, titrated positive end expiratory pressure and further Vt limitation, or control "protective" ventilation.Measurements Main Results: The primary...
The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as “the prevention and management the adverse effects cancer its treatment. This includes physical psychological symptoms side across continuum journey from diagnosis through treatment to post-treatment care. aims improve quality rehabilitation, secondary prevention, survivorship, end-of-life care”. article will provide an overview modern cancer, discussing definition, relationship with palliative...
This was a crossover study comparing mucin-based artificial saliva (Saliva Orthana™) and pilocarpine hydrochloride (Salagen™) in the management of xerostomia patients with advanced cancer. The found to be more effective than terms mean change visual analogue scale scores for (P = 0.003). Furthermore, reported that it had helped their xerostomia, wanted continue after study. However, associated side-effects < 0.001). These were usually as being mild. Of who used both treatments, 50%...
Opioids are recommended by the World Health Organization for moderate to severe cancer pain. Oxycodone is one of most commonly used opioids and metabolized in liver CYP3A4 CYP2D6 enzymes. The aim this cross-sectional study was assess relationship between oxycodone pharmacokinetics, pharmacodynamics genotypes "poor metaboliser" (PM), "extensive (EM) "ultra-rapid (URM) a cohort patients with pain.The were genotyped common variants serum concentrations metabolites determined. Pain assessed...