A5006764293- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Toxoplasma gondii Research Studies
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Rabies epidemiology and control
- HIV/AIDS Research and Interventions
- Kawasaki Disease and Coronary Complications
- Diabetes and associated disorders
- Neonatal Health and Biochemistry
- Bacterial Infections and Vaccines
- Hepatitis Viruses Studies and Epidemiology
- Adenosine and Purinergic Signaling
- Otolaryngology and Infectious Diseases
- Preterm Birth and Chorioamnionitis
- Hepatitis B Virus Studies
- Connective tissue disorders research
- Retinopathy of Prematurity Studies
- Analytical Chemistry and Chromatography
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
Columbia University
1994-2023
Presbyterian Hospital
2023
Rush University Medical Center
1992-2017
Cook County Health and Hospitals System
2017
University of Chicago
1979-2015
New England Research Institutes
1998
Rush University
1996
Stanford University
1994
Northwestern University
1994
Lurie Children's Hospital
1994
Journal Article Early and Longitudinal Evaluations of Treated Infants Children Untreated Historical Patients with Congenital Toxoplasmosis: The Chicago Collaborative Treatment Trial Get access James McAuley, McAuley From the Division Infectious Diseases, Departments Medicine, Pediatrics, Ophthalmology, Neurology, Radiology, Nursing, Biostatistics, Michael Reese Hospital, Rush-Presbyterian-St. Luke's Medical Center, Children's Memorial Northwestern University, Pritzker School University...
Journal Article Selective Intrapartum Chemoprophylaxis of Neonatal Group B Streptococcal Early-Onset Disease. I. Epidemiologic Rationale Get access K. M. Boyer, Boyer From the Divisions Infectious Diseases and Neonatology, Department Pediatrics; Division Fetal Maternal Medicine, Obstetrics Gynecology, Michael Reese Hospital Medical Center, University Chicago Pritzker School Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar C. A. Gadzala,...
Without treatment, congenital toxoplasmosis has recurrent, recrudescent, adverse outcomes. Long-term follow-up of infants with treated throughout their first year life pyrimethamine and sulfadiazine not been reported.Between 1981 2004, one hundred twenty (current mean age +/- standard deviation, 10.5 4.8 years) were 1 2 doses plus sulfadiazine; therapy was initiated shortly after birth continued for 12 months. Children who received treatment evaluated at predetermined intervals; the focus...
To determine the value of prenatal cultures in defining maternal colonization status at delivery, 5,586 pregnant women were screened visits for vaginal and rectal carriage group B streptococci (GBS). GBS isolated from 1,272 (22.8%). At semiquantitative obtained 393 carriers, whom 264 (67.2%) retained delivery. Seventeen (8.5%) 200 with negative acquired carriage. The predictive a positive culture was highest (72.5%) lowest (59.7%) only colonization. varied inversely interval between sampling...
Journal Article Selective Intrapartum Chemoprophylaxis of Neonatal Group B Streptococcal Early-Onset Disease. III. Interruption Mother-to-Infant Transmission Get access Kenneth M. Boyer, Boyer From the Division Infectious Diseases, Department Pediatrics, Michael Reese Hospital and Medical Center, University Chicago Pritzker School Medicine, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Cecile A. Gadzala, Gadzala Peggy D. Kelly, Kelly Samuel...
Background. Congenital toxoplasmosis presents as severe, life-altering disease in North America. If mothers of infants with congenital could be identified by risks, it would provide strong support for educating pregnant women about to eliminate this disease. Conversely, if not all risks are identifiable, undetectable suggested. A new test detecting antibodies sporozoites demonstrated that oocysts were the predominant source Toxoplasma gondii infection 4 American epidemics and children...
Congenital transmission of Toxoplasma gondii from a mother who was apparently immunologically competent and had toxoplasmic lymphadenitis 2 months before conception is described. Since no T. gondii-specific serological data were available for this the time her lymph node biopsy specimen obtained, studied by polymerase chain reaction (PCR) to determine whether B1 gene present. The predictive diagnostic value histologic findings previously considered be classic signs also studied. This done...
Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases diabetes. DNA methylation is a sensitive biomarker of aging-related processes novel epigenetic-based "clocks" can be used to estimate accelerated biological aging that may underlie risk. Metals alter methylation, yet little known about their individual combined impact on epigenetic age acceleration. Our objective was investigate the associations metals several...
To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis.Between January 1982 and March 1994, cranial computed tomography was performed 56 toxoplasmosis when they were newborns approximately 1 year old. Locations sizes noted.Forty had calcifications. By age, diminished or resolved 30 (75%) remained stable 10 (25%) these infants. Ten (33%) whose versus seven (70%) received less intensive antimicrobial treatment than other In contrast, a...
Pyrimethamine levels in sera, cerebrospinal fluid (CSF), and ventricular were measured by using reversed-phase high-pressure liquid chromatography. The specimens from 37 infants receiving pyrimethamine for treatment of suspect or proven congenital toxoplasmosis. half-life serum was 64 +/- 12 h when determined study terminal-phase kinetics samples obtained nine babies. This significantly different (P = 0.008) the (33 h) two babies same age taking phenobarbital. Serum at various intervals...
Human IgG antibody to the type-specific polysaccharide antigen of group B Streptococcus type Ia in sera mice was measured by enzyme-linked immunosorbent assay, previously standardized quantitative precipitation, 24 hr after passive immunization with human serum or affinity-chromatographed antibody. The concentrations needed protect against 90% lethal dose challenge varied bacterial inoculum and ranged from 0.25 l µg/ml using five strains Streptocuccus la. Affinity-chromatographed gave...
An indirect immunofluorescence (IF) assay has been developed as a useful semiquantitative method for determination of type-specific IgG antibody in human sera to the five serotypes group B Streptococcus. Antibody titers measured by IF correlated with passive protection chick embryos, and associated embryo were delineated. Except types Ia Ic, each streptococcal was completely absorbed homologous strains, unchanged incubation heterologous bacteria. For Ie, either or Ie strain native...
Journal Article Hepatitis A: Report of a Common-Source Outbreak with Recovery Possible Etiologic Agent. I. Epidemiologic Studies Get access Ronald T. Leger, Leger From the Phoenix Laboratories Division, Bureau Epidemiology, Center for Disease Control, Phoenix, Arizona Search other works by this author on: Oxford Academic PubMed Google Scholar Kenneth M. Boyer, Boyer Charles P. Pattison, Pattison James E. Maynard The Infectious Diseases, Volume 131, Issue 2, February 1975, Pages 163–166,...
Journal Article Human IgG Antibody to Group B Streptococcus Type III: Comparison of Protective Levels in a Murine Model with Infected Neonates Get access Samuel P. Gotoff, Gotoff From the Department Pediatrics, University Chicago, Pritzker School ofMedicine, Michael Reese Hospital and Medical Center, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Christine Odell, Odell Cynthia K. Papiemiak, Papiemiak Melvin E. Klegerman, Klegerman Kenneth M. Boyer...
In collaborative clinical trials. two-dose regimens of four monovalent A/New Jersey (NJ)/76 influenza virus vaccines were evaluated in 89 children aged six to 35 months. Clinical reactions vaccination consisted primarily low-grade fever. Rectal temperatures between 100 F and 102 occurred less frequently after inoculation with split-product (seven [23%] 31 children) than whole-virus (19 [33%] 58). After administration single doses vaccines, titers hemagglutination-inhibiting (HAl) antibody...
To identify women colonized with group B streptococci during parturition, we used pooled type-specific fluorescent antibody to examine vaginal swabs enriched by preincubation in selective broth medium. In preliminary experiments, streptococcus strain III-Bell was reliably detectable at concentrations of greater than 10(5) colony-forming units per ml, achieved after 6 h incubation small inocula (18 26 units). Of the from 924 parturient examined prospectively both and bacteriology techniques,...
Journal Article IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) Bivalent Jersey/76-A/Victoria/75) Influenza Virus Vaccines Get access Kenneth M. Boyer, Boyer Division Infectious Diseases, Department Of Pediatrics, UCLA School Medicine, Los Angeles, California Search for other works by this author on: Oxford Academic PubMed Google Scholar James D. Cherry, Cherry Please address requests reprints to Dr. Center the Health Sciences,...
We studied the concentration of circulating human immunoglobulin G (IgG) antibody to native capsular polysaccharide group B streptococcus (GBS) type Ib necessary protect mice against lethal challenge by laboratory and clinical GBS strains. Antibody was measured an enzyme-linked immunosorbent assay in which antigen coupled serum albumin used. The standardized a quantitative precipitation test, using specific IgG purified affinity chromatography. anti-GBS level-protection curves for 90% dose...