Wnurinham Silva
A5036937120- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Infant Development and Preterm Care
- Chronic Disease Management Strategies
- Neonatal and fetal brain pathology
- Physical Activity and Health
- Global Public Health Policies and Epidemiology
- Mobile Health and mHealth Applications
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Maternal Mental Health During Pregnancy and Postpartum
- Health Policy Implementation Science
- Delphi Technique in Research
- Healthcare Systems and Reforms
- Liver Disease Diagnosis and Treatment
- Innovation and Socioeconomic Development
- Health Promotion and Cardiovascular Prevention
- Mental Health and Patient Involvement
- Primary Care and Health Outcomes
- Pharmaceutical Economics and Policy
- Epigenetics and DNA Methylation
- Pharmaceutical Quality and Counterfeiting
- Family and Disability Support Research
University of Oulu
2022-2024
Imperial College London
2019-2023
Introduction Understanding context and how this can be systematically assessed incorporated is crucial to successful implementation. We describe has been (including exploration or evaluation) in Global Alliance for Chronic Diseases (GACD) implementation research projects focused on improving health people with at risk of chronic disease contextual lessons were into the intervention process. Methods Using a web-based semi-structured questionnaire, we conducted cross-sectional survey collect...
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to utero growth factors successive pregnancies may impact later life via persistent DNA methylation alterations. We investigated Illumina array data each 16 cohorts (8164 newborns) European, African, Latino ancestries from the Pregnancy Childhood Epigenetics Consortium. Meta-analyzed demonstrated systematic variation 341 CpGs (FDR adjusted P < 0.05) 1107 regions. Forty...
South Asians are at high risk of type 2 diabetes (T2D). We assessed whether intensive family-based lifestyle intervention leads to significant weight loss, improved glycaemia and blood pressure in adults elevated for T2D.
Abstract Background and aims This paper describes the data resource profile of South Asia Biobank (SAB), which was set up in from November 2018 to March 2020, identify risk factors their complex interactions underlying development type-2 diabetes mellitus, cardiovascular disease other chronic diseases Asians. Data basics cross-sectional population-based study has recruited 52713 Asian adults 118 surveillance sites at five centres excellence (Bangladesh, North India, Pakistan Sri Lanka)....
Abstract Background People from South Asia are at increased risk of type 2 diabetes (T2D). There is an urgent need to develop approaches for the prevention T2D in Asians that cost-effective, generalisable and scalable across settings. Hypothesis Compared usual care, can be reduced amongst with central obesity or raised HbA1c, through a 12-month lifestyle modification programme delivered by community health workers. Design Cluster randomised clinical trial (1:1 allocation intervention care),...
Abstract Background South Asians are at high risk of type 2 diabetes (T2D). Lifestyle modification is effective preventing T2D amongst Asians, but the approaches to screening and intervention limited by costs, poor scalability thus low impact on burden. An intensive family-based lifestyle programme for prevention was developed. The aim iHealth-T2D trial compare effectiveness this with usual care. Methods designed as a cluster randomised controlled (RCT) conducted 120 sites across India,...
Abstract Background South Asians are at high risk of type 2 diabetes (T2D). Lifestyle modification is effective preventing T2D amongst Asians, but the approaches to screening and intervention limited by high-costs, poor scalability thus low impact on burden. An intensive family-based lifestyle programme for prevention was developed. The aim iHealth-T2D trial compare effectiveness this with usual care. Methods designed as a cluster randomised controlled (RCT) conducted 120 locations across...
Abstract Background People from South Asia are at increased risk of type 2 diabetes (T2D). There is an urgent need to develop approaches for prevention T2D in Asians, that cost-effective, generalisable and scalable across settings. Hypothesis Compared usual care, can be reduced amongst Asians with central obesity or raised HbA1c, through a 12 month lifestyle modification programme delivered by community health workers. Design Cluster randomised clinical trial (1:1 allocation Intervention...