A5037199217- Autism Spectrum Disorder Research
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Congenital heart defects research
- Folate and B Vitamins Research
- Child Nutrition and Water Access
- Heavy Metal Exposure and Toxicity
- Pregnancy and preeclampsia studies
- Air Quality and Health Impacts
- Amyotrophic Lateral Sclerosis Research
- Health, Environment, Cognitive Aging
- Effects and risks of endocrine disrupting chemicals
- Cancer Risks and Factors
- Neonatal Respiratory Health Research
- Neurogenetic and Muscular Disorders Research
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Digestive system and related health
- Noise Effects and Management
- Energy and Environment Impacts
- Child Nutrition and Feeding Issues
- Animal Genetics and Reproduction
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Genetic Syndromes and Imprinting
University of Michigan–Ann Arbor
2017-2025
University of North Dakota
2023
Michigan United
2018-2021
University of Michigan–Dearborn
2021
Autism spectrum disorder (ASD) involves complex genetics interacting with the perinatal environment, complicating discovery of common genetic risk. The epigenetic layer DNA methylation shows dynamic developmental changes and molecular memory in utero experiences, particularly placenta, a fetal tissue discarded at birth. However, current array-based methods to identify novel ASD risk genes lack coverage most structurally epigenetically variable regions human genome.
Abstract The placenta mediates adverse pregnancy outcomes, including preeclampsia, which is characterized by gestational hypertension and proteinuria. Placental cell type heterogeneity in preeclampsia not well-understood limits mechanistic interpretation of bulk gene expression measures. We generated single-cell RNA-sequencing samples for integration with existing data to create the largest deconvolution reference 19 fetal 8 maternal types from placental villous tissue ( n = 9 biological...
Saliva is a widely used biological sample, especially in pediatric research, containing heterogenous mixture of immune and epithelial cells. Associations exposure or disease with saliva DNA methylation can be influenced by cell-type proportions. Here, we developed reference panel to estimate interindividual heterogeneity whole studies. was collected from 22 children (7–16 years) sorted into cells, using size exclusion filtration magnetic bead sorting. measured the Illumina MethylationEPIC...
Prenatal exposure to metals is hypothesized be associated with child autism. We aim investigate the joint and individual effects of prenatal urine including lead (Pb), mercury (Hg), manganese (Mn), selenium (Se) on Social Responsiveness Scale (SRS) scores.
Abstract Cognitive impairment among older adults is a growing public health challenge and environmental chemicals may be modifiable risk factors. A wide array of has not yet been tested for association with cognition in an environment-wide framework. In the US National Health Nutrition Examination Survey (NHANES) 1999 - 2000 2011 2014 cross-sectional cycles, was assessed using Digit Symbol Substitution Test (DSST, scores 0 117) participants aged 60 years older. Concentrations measured blood...
Lead (Pb) exposure is associated with a wide range of neurological deficits. Environmental exposures may impact epigenetic changes, such as DNA methylation, and can affect neurodevelopmental outcomes over the life-course. Mating mice were obtained from genetically invariant C57BL/6J background agouti viable yellow Avy strain. Virgin dams (a/a) randomly assigned 0 ppm (control), 2.1 (low), or 32 (high) Pb-acetate water two weeks prior to mating male (Avy/a), this continued through weaning. At...
Abstract Smoking impacts DNA methylation genome-wide in blood of newborns from maternal smoking during pregnancy and adults personal smoking. We compared smoking-related lung adenocarcinoma (61 never smokers, 91 current 238 former smokers) quantified with the Illumina450k BeadArray The Cancer Genome Atlas published large consortium meta-analyses newborn adult blood. assessed whether CpG sites related to were enriched signal. Testing CpGs differentially methylated by smoke exposure, we...
<h3>Background and Objectives</h3> Most patients with amyotrophic lateral sclerosis (ALS) lack a monogenic mutation. This study evaluates ALS cumulative genetic risk in an independent Michigan Spanish replication cohort using polygenic scores. <h3>Methods</h3> Participant samples from University of were genotyped assayed for the chromosome 9 open reading frame 72 hexanucleotide expansion. Final size was 219 223 healthy controls after genotyping participant filtering. Polygenic scores...
Lead (Pb) exposure is ubiquitous with permanent neurodevelopmental effects. The hippocampus brain region involved in learning and memory heterogeneous cellular composition. cell type-specific responses to Pb are unknown. objective of this study examine perinatal treatment effects on adult gene expression, at the level individual cells. In mice perinatally exposed control water or a human physiologically relevant (32 ppm maternal drinking water) Pb, 2 weeks prior mating through weaning, we...
Background: Pregnancy measures of DNA methylation, an epigenetic mark, may be associated with autism spectrum disorder (ASD) development in children. Few ASD studies have considered prospective designs methylation measured multiple tissues and tested overlap genetic risk loci. Objectives: To estimate associations between maternal blood, cord placenta later diagnosis ASD, to evaluate enrichment ASD-associated for known genes. Methods: In the Early Autism Risk Longitudinal Investigation...
Environmental chemical exposures influence immune system functions, and humans are exposed to a wide range of chemicals, termed the "exposome". A comprehensive, discovery analysis associations multiple families with biomarkers is needed. In this study, we tested between environmental concentrations biomarkers. We analyzed United States cross-sectional National Health Nutrition Examination Survey (NHANES 1999-2018). Chemical biomarker were measured in blood or urine (196 17 families). Immune...
ABSTRACT Background The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both genetic and environmental factors. This study investigates associations between metal measures in plasma urine, ALS risk survival, exposure sources. Methods Participants with without from Michigan provided urine samples for measurement via inductively coupled mass spectrometry. Odds hazard ratios each were computed using survival models. Environmental scores (ERS) created to evaluate the association...
The maternal epigenome may be responsive to prenatal metals exposures. We tested whether are associated with concurrent differential whole blood DNA methylation. In the Early Autism Risk Longitudinal Investigation cohort, we measured first or second trimester concentrations (cadmium, lead, mercury, manganese, and selenium) using inductively coupled plasma mass spectrometry. methylation in was on Illumina 450 K array. A subset sample of 97 women had both measures available for analysis, all...
Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3 fatty acids, zinc, A, B6, B12, D, usually they higher concentrations of acid iron than regular multivitamins in the US Nutrient levels can impact epigenetic factors such as DNA methylation, relationships between maternal prenatal methylation been relatively understudied. We examined first month...
Importance Neighborhood segregation and poverty may be important drivers of health inequities. Epigenomic factors, including DNA methylation clocks that mark underlying biological aging, have been implicated in the link between social factors health. Objective To examine associations neighborhood with 4 trained to capture either chronological age or physiological dysregulation. Design, Setting, Participants This cohort study uses data from Multi-Ethnic Study Atherosclerosis (MESA), a...